公开(公告)号：US20240277828A1

公开(公告)日：2024-08-22

申请号：US18653422

申请日：2024-05-02

申请人： SANOFI PASTEUR INC

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Guadalupe CORTES-GARCIA ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  Thorsten VOGEL ,  William WARREN

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04

CPC分类号： A61K39/145 ,  A61P37/04 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70

摘要： Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.

公开(公告)号：US20240269258A1

公开(公告)日：2024-08-15

申请号：US18627824

申请日：2024-04-05

申请人： SANOFI PASTEUR INC.

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Philip DAVIDSON ,  Maryann GIEL-MOLONEY ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  William WARREN ,  Konstantin ZELDOVICH

IPC分类号： A61K39/145 ,  A61K9/00 ,  A61K39/00 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61K9/0019 ,  C07K14/005 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16322 ,  C12N2760/16334

摘要： Disclosed are multivalent vaccine or immunogenic compositions comprising influenza virus hemagglutinin (HA) from standard of care influenza virus strains, or ribonucleic acid molecules encoding the same; and one or more influenza virus HA identified or designed by machine learning, or one or more ribonucleic acid molecules that encode the influenza virus HA identified or designed by machine learning. Also disclosed are methods of using the vaccine or immunogenic compositions.

公开(公告)号：US20240269270A1

公开(公告)日：2024-08-15

申请号：US18042637

申请日：2021-08-23

申请人： SANOFI PASTEUR INC. ,  GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Natalie ANOSOVA ,  Salvador Fernando AUSAR ,  Catherine BERRY ,  Florence BOUDET ,  Thomas BREUER ,  Danilo CASIMIRO ,  Roman M. CHICZ ,  Gustavo DAYAN ,  Guy DE BRUYN ,  Carlos DIAZGRANADOS ,  Tong-Ming FU ,  Marie GARINOT ,  Lorry GRADY ,  Sanjay GURUNATHAN ,  Kirill KALNIN ,  Nikolai KHRAMTSOV ,  Valérie LECOUTURIER ,  Nausheen RAHMAN ,  Sophie RUIZ ,  Stephen SAVARINO ,  Saranya SRIDHAR ,  Indresh K. SRIVASTAVA ,  James TARTAGLIA ,  Timothy TIBBITTS

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/215 ,  A61P37/04 ,  C07K14/005 ,  C12N5/07 ,  C12N7/00

CPC分类号： A61K39/39 ,  A61K39/215 ,  A61P37/04 ,  C07K14/005 ,  C12N5/0601 ,  C12N7/00 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2770/20022 ,  C12N2770/20034 ,  C12N2770/20071

摘要： Provided are novel vaccines for prophylactic treatment of SARS-COV-2 infections and COVID-19 and methods of making the vaccines, wherein the vaccines contain an oil-in-water emulsion comprising tocopherol and squalene.

公开(公告)号：US20240016918A1

公开(公告)日：2024-01-18

申请号：US18042626

申请日：2021-08-23

申请人： SANOFI PASTEUR INC.

发明人： Natalie ANOSOVA ,  Salvador Fernando AUSAR ,  Catherine BERRY ,  Florence BOUDET ,  Danilo CASIMIRO ,  Roman M. CHICZ ,  Gustavo DAYAN ,  Guy DE BRUYN ,  Carlos DIAZGRANADOS ,  Tong-Ming FU ,  Marie GARINOT ,  Lorry GRADY ,  Sanjay GURUNATHAN ,  Kirill KALNIN ,  Nikolai KHRAMTSOV ,  Valérie LECOUTURIER ,  Nausheen RAHMAN ,  Sophie RUIZ ,  Stephen SAVARINO ,  Saranya SRIDHAR ,  Indresh K. SRIVASTAVA ,  James TARTAGLIA ,  Timothy TIBBITTS

IPC分类号： A61K39/215 ,  A61P37/04

CPC分类号： A61K39/215 ,  A61P37/04 ,  A61K2039/53

摘要： Provided are novel vaccines for prophylactic treatment of SARS-CoV-2 infections and COVID-19 and methods of making the vaccines.