公开(公告)号：US20240277828A1

公开(公告)日：2024-08-22

申请号：US18653422

申请日：2024-05-02

申请人： SANOFI PASTEUR INC

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Guadalupe CORTES-GARCIA ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  Thorsten VOGEL ,  William WARREN

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04

CPC分类号： A61K39/145 ,  A61P37/04 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70

摘要： Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.

公开(公告)号：US20240335525A1

公开(公告)日：2024-10-10

申请号：US18682372

申请日：2022-08-10

申请人： SANOFI PASTEUR INC.

发明人： Mario BARRO ,  Yvonne CHAN ,  Guadalupe CORTES-GARCIA ,  Raul GOMILA ,  Liqun HAN ,  Justin KLEKOTA ,  Fuqin MA ,  Satyajit RAY ,  Svetlana STEGALKINA ,  Tod STRUGNELL ,  Irina USTYUGOVA ,  Thorsten VOGEL ,  Jianxin ZHANG

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C07K14/705 ,  C12N9/24

CPC分类号： A61K39/145 ,  A61P37/04 ,  C07K14/005 ,  C07K14/70596 ,  C12N9/2402 ,  C12Y302/01018 ,  A61K2039/645 ,  C07K2319/02 ,  C12N2760/16134

摘要： Provided are modified influenza virus subtype 2 neuraminidase molecules lacking all or substantially all of the stalk region that form active, soluble tetrameric neuraminidase when expressed in host cells and vaccine compositions comprising the tetrameric neuraminidase or a nucleic acid encoding the modified monomeric influenza virus subtype 2 neuraminidase molecules that forms tetrameric NA when expressed in a cell. Also provided are methods of using the vaccine compositions to vaccinate or immunize a subject against influenza virus.

公开(公告)号：US20170121373A1

公开(公告)日：2017-05-04

申请号：US15315257

申请日：2015-05-29

申请人： SANOFI PASTEUR INC.

发明人： Guadalupe CORTES-GARCIA ,  Timothy ALEFANTIS ,  Mark PARRINGTON

IPC分类号： C07K14/005 ,  A61K39/145 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/57 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/16022 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  G01N33/56983 ,  G01N2333/11

摘要： The present invention provides, among other things, compositions and methods for analyzing the expression and conformation of engineered influenza hemagglutinin In particular, the present invention provides methods of screening in silico designed HA antigens using neutralizing antibody panels specific to conserved epitopes. In some embodiments, the HAs are down selected for inclusion in universal influenza vaccines based upon their binding to neutralizing antibody panels in immunostaining assays.