公开(公告)号：US20150321159A1

公开(公告)日：2015-11-12

申请号：US14410706

申请日：2013-08-08

Applicant: SEKISUI CHEMICAL CO., LTD.

Inventor： Tadashi IWAMOTO ,  Hiroshi YAMAUCHI

IPC: B01J13/12

CPC classification number: B01J13/12 ,  A23L27/72 ,  A23P10/30 ,  A61K8/11 ,  A61K8/65 ,  A61K8/8129 ,  A61K8/8147 ,  A61K8/8176 ,  A61K9/5026 ,  A61K9/5057 ,  A61K9/5089 ,  A61K2800/10 ,  A61K2800/412 ,  A61Q19/00 ,  B01J13/125 ,  Y10T428/2998

Abstract: The present invention aims to provide a method for producing microcapsules, wherein the method can control the particle size and produce microcapsules excellent in retentivity and releasability of a water-soluble core agent. The present invention also aims to provide a microcapsule excellent in retentivity and releasability of a water-soluble core agent. The present invention provides a method for producing microcapsules comprising the steps of: preparing an emulsion by dispersing an aqueous solution A obtained by dissolving at least an aqueous solvent-soluble polymer and a water-soluble core agent in an aqueous solvent in a non-polar solution B obtained by dissolving an emulsifier or a dispersant in a non-polar medium; and forming a core-shell structure in which the water-soluble core agent is covered with a shell containing the aqueous solvent-soluble polymer by heating the emulsion at a temperature of 20° C. to 100° C. and/or decompressing the emulsion at a pressure of 0.1 to 0.001 MPa to remove the aqueous solvent, the weight ratio of the aqueous solution A to the non-polar solution B being 1/10 to 1/1.

Abstract translation: 本发明的目的在于提供一种生产微胶囊的方法，其中该方法可以控制粒度并产生水溶性核心试剂的保持性和脱模性优异的微胶囊。 本发明还旨在提供一种水溶性核心试剂的保持性和脱模性优异的微胶囊。 本发明提供一种生产微胶囊的方法，包括以下步骤：通过将至少将水性溶剂可溶性聚合物和水溶性芯剂溶解在水性溶剂中而得到的水溶液A分散在非极性 通过将乳化剂或分散剂溶解在非极性介质中获得的溶液B; 并且通过在20℃至100℃的温度下加热乳液和/或使乳液减压而形成其中水溶性核心试剂被含有水溶性可溶性聚合物的壳覆盖的核 - 壳结构。 在0.1〜0.001MPa的压力下除去水性溶剂，水溶液A与非极性溶液B的重量比为1/10〜1/1。

公开(公告)号：US20200181486A1

公开(公告)日：2020-06-11

申请号：US16329095

申请日：2017-08-31

Applicant: SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

Inventor： Tadashi IWAMOTO ,  Satoru SUGIMOTO ,  Takeshi WAKIYA ,  Shinichiro KITAHARA ,  Maasa YAJI

IPC: C09K11/06 ,  G01N33/58 ,  G01N33/533 ,  A61K49/00 ,  G01N33/543 ,  C09K11/02

Abstract: The present invention provides fluorescent particles for a diagnostic agent which contain a synthetic polymer and at least 10 mass %, on a total particle mass basis, of an aggregation-induced emission material, and have on the surface thereof a binding partner which binds with an analyte. These fluorescent particles for a diagnostic agent are non-toxic, have improved visibility and reproducibility, and support a binding partner for an analyte.

公开(公告)号：US20180282491A1

公开(公告)日：2018-10-04

申请号：US15764801

申请日：2016-09-30

Applicant: SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

Inventor： Satoru SUGIMOTO ,  Tadashi IWAMOTO ,  Takeshi WAKIYA ,  Shinichiro KITAHARA ,  Maasa IKEGAMI

IPC: C08J3/14 ,  C08L9/06 ,  G01N33/545

Abstract: A polymer fine particle including a block copolymer having two or more segments, wherein the polymer fine particle has a microphase separated structure on a surface thereof, the number-average particle size is 50 nm to 1000 nm, and the coefficient of variation is less than 20%. The polymer fine particle permits highly sensitive assay by controlling the antigen- or antibody-immobilized state of the particle surface.

公开(公告)号：US20190226988A1

公开(公告)日：2019-07-25

申请号：US16329116

申请日：2017-08-31

Applicant: SEKISUI CHEMICAL CO., LTD. ,  SEKISUI MEDICAL CO., LTD.

Inventor： Tadashi IWAMOTO ,  Satoru SUGIMOTO ,  Takeshi WAKIYA ,  Shinichiro KITAHARA ,  Maasa YAJI

IPC: G01N21/64 ,  G01N33/543

Abstract: This analyte concentration measuring method including: preparing a mixed solution by mixing a sample solution containing an analyte, with a solution containing aggregation-induced emission fluorescent material-containing particles that have a binding partner which binds with the analyte and that agglutinate and fluoresce when the analyte binds to the binding partner; measuring the fluorescence intensity generated from the aggregation-induced emission fluorescent material-containing particles in the mixed solution; and comparing a fluorescence intensity calibration curve for analyte concentration with the fluorescence intensity, and associating the fluorescence intensity with the analyte concentration in the mixed solution. Employing agglutinating-luminescent-material-containing particles enables measurements to be carried out with a satisfactory detection sensitivity while suppressing background fluorescence.