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    PROSTHESIS FOR IN VIVO INSERTION, COATED WITH CROSS-LINKED POLYPHOSPHORYLCHOLINE
    1.
    发明申请
    PROSTHESIS FOR IN VIVO INSERTION, COATED WITH CROSS-LINKED POLYPHOSPHORYLCHOLINE 有权

    公开(公告)号：US20210378814A1

    公开(公告)日：2021-12-09

    申请号：US17412124

    申请日：2021-08-25

    申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  BS RESEARCH CO. LTD.

    发明人： Tae Hyun Choi ,  Yan Lee ,  Ji Ung Park ,  Ji Yeon Ham ,  Hee Jin Kim ,  Suk Wha Kim ,  Hye Jeong Min

    IPC分类号： A61F2/12 ,  A61L27/32 ,  A61L27/34 ,  A61L27/28 ,  A61F2/00 ,  B05D1/02

    摘要： The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.
    An in-vivo implantable prosthesis coated with crosslinked polyphosphorylcholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group according to the present invention, and then irradiating uv rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.

    Prosthesis for in vivo insertion, coated with cross-linked polyphosphorylcholine
    3.
    发明授权
    Prosthesis for in vivo insertion, coated with cross-linked polyphosphorylcholine 有权

    公开(公告)号：US11129706B2

    公开(公告)日：2021-09-28

    申请号：US15304780

    申请日：2015-04-17

    申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  BS RESEARCH CO. LTD.

    发明人： Tae Hyun Choi ,  Yan Lee ,  Ji Ung Park ,  Ji Yeon Ham ,  Hee Jin Kim ,  Suk Wha Kim ,  Hye Jeong Min

    IPC分类号： C08F2/12 ,  A61F2/12 ,  A61L27/32 ,  A61L27/34 ,  A61L27/28 ,  A61F2/00 ,  B05D1/02 ,  C08F2/48

    摘要： The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.
    An in-vivo implantable prosthesis coated with crosslinked polyphosphoryicholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group according to the present invention, and then irradiating UV rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.