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公开(公告)号：US20210378814A1
公开(公告)日：2021-12-09
申请号：US17412124
申请日：2021-08-25
发明人： Tae Hyun Choi , Yan Lee , Ji Ung Park , Ji Yeon Ham , Hee Jin Kim , Suk Wha Kim , Hye Jeong Min
摘要： The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.
An in-vivo implantable prosthesis coated with crosslinked polyphosphorylcholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group according to the present invention, and then irradiating uv rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.-
公开(公告)号：US20220218872A1
公开(公告)日：2022-07-14
申请号：US17610418
申请日：2020-05-07
发明人： Yan Lee , Sun Ah Kang , Tae Hyun Choi , Ji Ung Park , Seul Ah Kim , Jung Ah Kim , Mi Ok Kim , Young Min Kim , Xian Jin , Wufuer Maierdanjiang , Gee Ho Park , Byoung Jun Jeon , Eun Jung Choi , Yan Huang
摘要： Provided is a method for coating an implant using heat, and more particularly to a method for coating only the surface of an implant with a biocompatible polymer by using heat while maintaining physical characteristics of the implant.
The method for coating an implant using heat according to the present invention may effectively introduce a biocompatible polymer onto a three-dimensional material surface and thus may overcome the spatial limitations of light, and enables mass-coating and thus may be effectively used in the manufacture of an implant coated with a biocompatible polymer.-
公开(公告)号：US11925547B2
公开(公告)日：2024-03-12
申请号：US17412124
申请日：2021-08-25
发明人： Tae Hyun Choi , Yan Lee , Ji Ung Park , Ji Yeon Ham , Hee Jin Kim , Suk Wha Kim , Hye Jeong Min
CPC分类号： A61F2/12 , A61F2/0059 , A61F2/0063 , A61L27/28 , A61L27/32 , A61L27/34 , B05D1/02 , A61F2002/0086 , A61F2002/009 , A61L2300/216 , A61L2400/18 , A61L2430/04 , C08F2/48
摘要： The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.
An in-vivo implantable prosthesis coated with crosslinked polyphosphorylcholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group according to the present invention, and then irradiating uv rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.-
公开(公告)号：US11129706B2
公开(公告)日：2021-09-28
申请号：US15304780
申请日：2015-04-17
发明人： Tae Hyun Choi , Yan Lee , Ji Ung Park , Ji Yeon Ham , Hee Jin Kim , Suk Wha Kim , Hye Jeong Min
摘要： The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine.
An in-vivo implantable prosthesis coated with crosslinked polyphosphoryicholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group according to the present invention, and then irradiating UV rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.-
公开(公告)号：US12122812B2
公开(公告)日：2024-10-22
申请号：US16979078
申请日：2019-03-05
发明人： Byeong Moon Kim , Yan Lee , Eun Joung Choi , Dongwook Jung
IPC分类号： C07K1/13 , A61K47/60 , C07K14/505 , C07K19/00 , A61K38/00
CPC分类号： C07K14/505 , A61K47/60 , C07K19/00 , C12Y304/21001 , A61K38/00
摘要： Disclosed are a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing same as an active ingredient. The method for preparing a biomaterial to which a compound represented by chemical formula 2 is coupled, of the present invention, allows the compound represented by chemical formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.
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6.发明申请ALPHA HELIX CELL-PENETRATING PEPTIDE MULTIMER, PREPARATION METHOD THEREFOR AND USE THEREFOR 审中-公开ALPHA HELIX细胞培养基多肽，其制备方法及其用途公开(公告)号：US20160229894A1
公开(公告)日：2016-08-11
申请号：US15030051
申请日：2014-10-17
发明人： Jaehoon Yu , Yan Lee , Soonsil Hyun , Sangmok Jang
IPC分类号： C07K7/08 , A61K47/42 , A61K31/713 , C12N15/113
CPC分类号： C07K7/08 , A61K31/713 , A61K38/00 , A61K47/42 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to an α-helical cell-penetrating peptide multimer, a preparation method thereof and the use thereof, and more particularly, to a peptide multimer comprising a plurality of amphipathic peptides, a method for preparing the peptide multimer, a composition for preventing or treating HIV, which comprises the peptide multimer as an active ingredient, and a composition for intracellular delivery of a biologically active substance, which comprises the peptide multimer and the biologically active substance.
摘要翻译： 本发明涉及α-螺旋细胞穿透肽多聚体及其制备方法及其用途，更具体地涉及包含多个两亲肽的肽多聚体，制备肽多聚体的方法，用于 预防或治疗包含肽多聚体作为活性成分的HIV，以及包含肽多聚体和生物活性物质的生物活性物质的细胞内递送的组合物。
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公开(公告)号：US11123400B2
公开(公告)日：2021-09-21
申请号：US15761089
申请日：2016-09-19
发明人： Jaehoon Yu , Yan Lee , Soonsil Hyun , Seo Yeon Kim , Sun Mi Jin , Yunhwa Choi , Doyeon Jo , Seonju Lee
IPC分类号： A61K38/10 , A01N37/18 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/16 , C07K7/08 , A61K31/616 , A61K31/431 , A61K31/192 , A61K31/05 , A61K31/12 , A61K31/5377 , A61K31/366 , A61P31/04 , A61P29/00 , A61P9/00 , A61K38/06 , A61K38/00 , A61K47/64
摘要： The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
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公开(公告)号：US20170342108A1
公开(公告)日：2017-11-30
申请号：US15529967
申请日：2015-11-27
发明人： Jaehoon Yu , Soonsil Hyun , Yan Lee , Seonju Lee
IPC分类号： C07K7/08 , A61K47/42 , C12N15/113 , A61K47/64 , C07K1/107 , A61K31/713
CPC分类号： C07K7/08 , A61K31/713 , A61K38/12 , A61K47/42 , A61K47/64 , A61K47/6455 , C07K1/1075 , C07K1/1077 , C07K1/113 , C07K14/001 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.
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公开(公告)号：US20210054038A1
公开(公告)日：2021-02-25
申请号：US16979078
申请日：2019-03-05
发明人： Byeong Moon Kim , Yan Lee , Eun Joung Choi , Dongwook Jung
IPC分类号： C07K14/505 , C07K19/00 , A61K47/60
摘要： Disclosed are a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing same as an active ingredient. The method for preparing a biomaterial to which a compound represented by chemical formula 2 is coupled, of the present invention, allows the compound represented by chemical formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.
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公开(公告)号：US10308684B2
公开(公告)日：2019-06-04
申请号：US15529967
申请日：2015-11-27
发明人： Jaehoon Yu , Soonsil Hyun , Yan Lee , Seonju Lee
IPC分类号： A61K38/10 , A61K38/16 , A61K38/00 , A61K38/04 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K7/08 , A61K47/42 , A61K47/64 , A61K31/713 , C07K1/107 , C12N15/113 , C07K1/113 , C07K14/00 , A61K38/12
摘要： The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.
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