公开(公告)号：US10929039B2

公开(公告)日：2021-02-23

申请号：US16138123

申请日：2018-09-21

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  Seoul National University R&DB Foundation

发明人： Sunghoon Kwon ,  Wook Park ,  Yeongjae Choi ,  Taehoon Ryu ,  Suk-Heung Song ,  Hyeli Kim ,  Seojoo Kim

IPC分类号： G06F3/06 ,  C07H21/04 ,  C07H21/02

摘要： Disclosed is a storage method of DNA digital data, including: encoding a plurality of bit data to a plurality of base sequences including at least one degenerate base; and synthesizing at least two types of bases constituting the at least one degenerate base on a substrate based on a mixing ratio.

公开(公告)号：US20190317684A1

公开(公告)日：2019-10-17

申请号：US16138123

申请日：2018-09-21

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  Seoul National University R&DB Foundation

发明人： Sunghoon Kwon ,  Wook Park ,  Yeongjae Choi ,  Taehoon Ryu ,  Suk-Heung Song ,  Hyeli Kim ,  Seojoo Kim

IPC分类号： G06F3/06 ,  C07H21/04 ,  C07H21/02

摘要： Disclosed is a storage method of DNA digital data, including: encoding a plurality of bit data to a plurality of base sequences including at least one degenerate base; and synthesizing at least two types of bases constituting the at least one degenerate base on a substrate based on a mixing ratio.

公开(公告)号：US11987693B2

公开(公告)日：2024-05-21

申请号：US16335296

申请日：2017-10-10

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

发明人： Sung Hoon Kwon ,  Wook Park ,  Yeong Jae Choi ,  Hyung Jong Bae ,  Tae Hoon Ryu ,  Suk Heung Song

IPC分类号： G06F16/22 ,  C08J3/12 ,  C08J9/28 ,  C08L35/02 ,  C12N15/11

CPC分类号： C08L35/02 ,  C08J3/128 ,  C08J9/286 ,  C12N15/11 ,  G06F16/2237 ,  C08J2201/046 ,  C08J2333/08 ,  C08J2335/02 ,  C08J2489/00

摘要： Biochemical carriers are provided. Each of the biochemical carriers includes: biochemical molecules having a sequence into which digital data information is encoded; a carrier particle composed of a polymer matrix and in which the biochemical molecules are connected to the surface or inside of the polymer matrix; and an index code introduced into the carrier particle. Also provided is a method for fabricating biochemical carriers. The fabrication method includes: encoding digital data into a sequence of biochemical molecules; synthesizing the biochemical molecules based on the encoded sequence; mixing the biochemical molecules with a photocurable material; curing the mixture to obtain carrier particles including a polymer matrix; and introducing an index code into the carrier particles simultaneously with or separately from the curing. Also provided is a method for restoring digital data from the biochemical carrier. The restoration method includes: analyzing the index code of the biochemical carrier; reacquiring the biochemical molecules from the biochemical carrier based on the analytical results of the index code; sequencing the biochemical molecules; and decoding the sequencing results to restore digital data.

公开(公告)号：US12121974B2

公开(公告)日：2024-10-22

申请号：US16487815

申请日：2018-05-29

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

发明人： Wook Park ,  Suk Heung Song

IPC分类号： B22F9/06 ,  B22F1/062 ,  B22F1/068 ,  B22F1/08 ,  B22F1/16 ,  B22F9/04 ,  C03B37/026 ,  C03B37/16 ,  C08K7/06 ,  C08K9/02 ,  D01F9/08 ,  D21H17/00 ,  D21H17/68 ,  D21H21/42 ,  G01N33/553

CPC分类号： B22F9/06 ,  B22F1/062 ,  B22F1/068 ,  B22F1/08 ,  B22F1/16 ,  B22F9/04 ,  C03B37/026 ,  C03B37/16 ,  C08K7/06 ,  C08K9/02 ,  D01F9/08 ,  D21H17/68 ,  D21H17/73 ,  D21H21/42 ,  G01N33/553 ,  B22F2009/046 ,  B22F2302/45 ,  C08K2201/01 ,  B22F2998/10 ,  B22F9/06 ,  B22F2009/065 ,  C22C1/10 ,  B22F1/08 ,  B22F1/068 ,  B22F1/16

摘要： Disclosed are: a method capable of preparing, in large-scaled quantity, nonspherical/asymmetric fine particles in which the physical factors (for example, size, shape, structure, etc.) of a fine wire (for example, glass-coated metal microwires) are controlled, through a convergence of nano technology (NT) and laser machining technology; and a use thereof applicable to various fields including bioassay and security.

公开(公告)号：US11447733B2

公开(公告)日：2022-09-20

申请号：US16486600

申请日：2018-01-15

申请人： UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY

发明人： Tong In Oh ,  Sung Hyun Kim ,  Wook Park ,  Eun Ah Lee

IPC分类号： C12M1/12 ,  C12M1/00 ,  C12N11/089

摘要： The present invention relates to transparent disc-shaped microparticles having polydopamine-modified surfaces and cell culture using the same. When the disc-shaped microparticles coated with polydopamine according to the present invention are used in cell culture, cell adhesive properties are improved and an inverted microscope may be employed to observe cells, which are major advantages when compared to conventional spherical microcarriers.

公开(公告)号：US12059682B2

公开(公告)日：2024-08-13

申请号：US16166209

申请日：2018-10-22

申请人： EzDiaTech Inc. ,  University-Industry Cooperation Group of Kyung Hee University

发明人： Yong Gyun Jung ,  Joo Ho Kim ,  Wook Park ,  Jin Sik Yoon ,  Suk Heung Song

IPC分类号： B01L3/00 ,  C12M1/32

CPC分类号： B01L3/5085 ,  B01L3/5027 ,  C12M23/12 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/16

摘要： Provided is a method for cell isolation and morphological analysis. The method includes: providing a substrate with one or more wells; inserting cell isolation devices, each of which has one side patterned with one or more microwells, into the wells; introducing a liquid medium including cells into the wells; allowing the microwells of the cell isolation devices to come into contact with the inner surfaces of the wells such that some of the cells are isolated and trapped at the level of individual cells in the microwells; and observing the morphological changes of the isolated cells.