公开(公告)号：US09734997B2

公开(公告)日：2017-08-15

申请号：US15105081

申请日：2013-12-17

申请人： SHIMADZU CORPORATION

发明人： Natsuyo Asano

IPC分类号： H01J49/00 ,  G01N30/72 ,  H01J49/06 ,  H01J49/16

CPC分类号： H01J49/005 ,  G01N30/7266 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/063 ,  H01J49/165

摘要： The degree of ion dissociation which occurs within a first intermediate vacuum chamber (212) maintained at a comparatively low degree of vacuum depends not only on the amount of energy of the ion but also on the size and other properties of the ion. Accordingly, a predetermined optimum level of DC bias voltage is applied to an ion guide (24) so as to create, within the first intermediate vacuum chamber (212), a DC electric field which barely induces the dissociation of an ion originating from a target compound in a sample while promoting the dissociation of an ion originating from a foreign substance which will form a noise signal in the observation of the target compound. The optimum DC bias voltage is previously determined by creating extracted ion chromatograms based on data collected under various DC bias voltages and evaluating the SN ratio using the chromatograms. Consequently, the accuracy and sensitivity of the quantitative determination is improved as compared to a conventional system in which only the signal strength of the target compound is considered.

公开(公告)号：US09929001B2

公开(公告)日：2018-03-27

申请号：US15511332

申请日：2014-09-17

申请人： SHIMADZU CORPORATION

发明人： Natsuyo Asano

IPC分类号： H01J49/00 ,  H01J49/16 ,  H01J49/42

CPC分类号： H01J49/167 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/0095 ,  H01J49/165 ,  H01J49/42

摘要： In a mass spectrometer according to the present invention, when MRM measurements for a plurality of MRM transitions need to be performed within one cycle, a measurement order rearranger determines an analysis sequence by sorting the measurement in ascending order of the absolute value of an optimum application voltage (an application voltage which gives the highest ionization efficiency) to the nozzle of the ESI probe. An analysis controller performs the analysis by controlling the high-voltage power source and other relevant units according to the determined analysis sequence. Since the voltage applied to the nozzle within one cycle has no period in which the voltage is changed in the decreasing direction with the same polarity, the cycle time becomes shorter than in a conventional device.

公开(公告)号：US12130267B2

公开(公告)日：2024-10-29

申请号：US17296642

申请日：2019-10-30

申请人： SHIMADZU CORPORATION

发明人： Tetsuo Tanigawa ,  Natsuyo Asano ,  Zhao Qi Zhan ,  Yin Ling Chew ,  Jun Xiang Lee ,  Jie Xing

IPC分类号： G01N30/34 ,  B01D15/32 ,  G01N30/02 ,  G01N30/60 ,  G01N30/72 ,  G01N30/88

CPC分类号： G01N30/34 ,  B01D15/325 ,  G01N30/7233 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/6013 ,  G01N2030/884

摘要： A large number of kinds of azo compounds which are representative hazardous substances in fiber products are divided into two groups. The compounds included in the first group are detected by an MRM measurement by a tandem mass spectrometer unit (12) in a measurement section (10) while a two-liquid gradient elution under an acidic condition is performed in a liquid chromatograph unit (11), using an aqueous ammonium acetate solution as mobile phase A, and a mixture of acetonitrile and an aqueous ammonium acetate solution as mobile phase B. On the other hand, the compounds included in the second group are detected by an MRM measurement while a two-liquid gradient elution under a neutral or weakly basic condition is performed using an aqueous ammonium bicarbonate solution as mobile phase A and acetonitrile as mobile phase B. An exhaustive quantitative analysis for major azo compounds can be achieved by performing the two analyses for the same sample. An efficient test with a shortened analysis period can thereby be performed.

公开(公告)号：US20150268203A1

公开(公告)日：2015-09-24

申请号：US14391810

申请日：2012-04-12

申请人： SHIMADZU CORPORATION

发明人： Natsuyo Asano

IPC分类号： G01N30/86 ,  G01N30/72 ,  H01J49/00 ,  H01J49/10

CPC分类号： G01N30/8631 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/86 ,  H01J49/0009 ,  H01J49/0036 ,  H01J49/005

摘要： An equation expressing a previously and experimentally determined relationship between the number of ions and a CV value is stored in a reference CV value calculation data memory. When mass spectrometry is performed for a target sample under measurement conditions including a loop time Tp and a dwell time Td, a chromatogram creator creates a chromatogram based on the analysis result and calculates a peak area value A. A CV-value-related information calculator computes the number X of ions by X=A×(Td/Tp), and based on the equation stored in the memory, calculates a CV value corresponding to the calculated number of ions. This is a reference CV value containing only statistical dispersion factors for data. This CV value is displayed in such a manner that it can be compared with an actual CV value calculated based on the variance of actually measured peak area values corresponding to a plurality of measurements.

摘要翻译： 在参考CV值计算数据存储器中存储表示离子数和CV值之间的先前和实验确定的关系的方程式。 当在包括循环时间Tp和停留时间Td的测量条件下对目标样品进行质谱分析时，色谱图创建器基于分析结果产生色谱图并计算峰面积值A.CV值相关信息计算器 通过X = A×（Td / Tp）计算离子数X，并且根据存储在存储器中的方程，计算与计算出的离子数相对应的CV值。 这是一个仅包含数据的统计色散因子的参考CV值。 该CV值以与可以对应于多个测量值的实际测量的峰值面积值的方差计算出的实际CV值进行比较的方式进行显示。