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公开(公告)号：US09532981B2
公开(公告)日：2017-01-03
申请号：US14496534
申请日：2014-09-25
Applicant: Shiseido Company, Ltd.
Inventor： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata , Eijiro Adachi
IPC: A61F2/10 , C12N5/071 , A61L27/60 , A61K31/4406 , A61L27/38 , A61K31/4184 , A61L27/36
Abstract: The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.
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Patent Agency Ranking
公开(公告)号：US11564959B2
公开(公告)日：2023-01-31
申请号：US16343749
申请日：2017-10-20
Applicant: SHISEIDO COMPANY, LTD.
Inventor： Shunsuke Iriyama , Saori Tanno
IPC: A61K36/03 , A61P29/00 , C12N9/24 , C12N9/50 , G01N33/50 , A61P43/00 , A61K31/4166 , A61P17/00 , A61K36/04 , A61K36/05 , C12N15/09 , G01N33/68 , C12Q1/68
Abstract: Provided is a screening method for a laminin 511 expression promoter, which takes the expression of laminin 511 as an indicator. Also provided is an agent for improving skin barrier function, elasticity, hydration and inflammation. This agent includes at least one extract selected from among a group consisting of brown algae, red algae and green algae.
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公开(公告)号：US09579310B2
公开(公告)日：2017-02-28
申请号：US14496534
申请日：2014-09-25
Applicant: Shiseido Company, Ltd.
Inventor： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata , Eijiro Adachi
IPC: A61F2/10 , C12N5/071 , A61L27/60 , A61K31/4406 , A61L27/38 , A61K31/4184 , A61L27/36
CPC classification number: A61K31/4406 , A61F2/105 , A61K8/4926 , A61K8/4946 , A61K8/64 , A61K31/4184 , A61K38/005 , A61K38/07 , A61K2800/782 , A61L27/362 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60 , A61Q19/08
Abstract: The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.
Abstract translation: 本发明涉及一种生产人造皮肤的方法，包括：将基质金属蛋白酶抑制剂和乙酰肝素酶抑制剂加入到人表皮角质形成细胞和人真皮成纤维细胞的人造皮肤形成培养基中，在人造皮肤形成培养基中培养细胞， 并形成人造皮肤。
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公开(公告)号：US20170071922A1
公开(公告)日：2017-03-16
申请号：US15363011
申请日：2016-11-29
Applicant: Shiseido Company, Ltd.
Inventor： Shunsuke Iriyama , Kenichi Umishio , Makoto Tsunenaga , Shinji Inomata , Eijiro Adachi
IPC: A61K31/4406 , A61K38/07 , A61Q19/08 , A61K8/49 , A61K8/64 , A61K31/4184 , A61K38/00
CPC classification number: A61K31/4406 , A61F2/105 , A61K8/4926 , A61K8/4946 , A61K8/64 , A61K31/4184 , A61K38/005 , A61K38/07 , A61K2800/782 , A61L27/362 , A61L27/3804 , A61L27/3813 , A61L27/3886 , A61L27/60 , A61Q19/08
Abstract: The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.
Abstract translation: 本发明涉及一种生产人造皮肤的方法，包括：将基质金属蛋白酶抑制剂和乙酰肝素酶抑制剂加入到人表皮角质形成细胞和人真皮成纤维细胞的人造皮肤形成培养基中，在人造皮肤形成培养基中培养细胞， 并形成人造皮肤。
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公开(公告)号：US20140080878A1
公开(公告)日：2014-03-20
申请号：US14082440
申请日：2013-11-18
Applicant: Shiseido Company, Ltd.
Inventor： Shunsuke Iriyama , Hirotada Fukunishi , Masaru Suetsugu , Satoshi Amano
CPC classification number: A61K8/4946 , A61K8/49 , A61K2800/782 , A61Q19/02 , A61Q19/08
Abstract: A heparanase activity inhibitor comprising, as an active ingredient, a cyclic carboxamide derivative represented by formula (I): wherein n is an integer of 1 to 3, R1 is hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, X is —CH2— or a group represented by —N(R2)—, and R2 is hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, or a salt thereof.
Abstract translation: 1.一种乙酰肝素酶活性抑制剂，其含有作为活性成分的式（I）表示的环状甲酰胺衍生物：其中n为1〜3的整数，R1为氢或任选被羟基取代的C 1-6烃基，X为 - CH 2 - 或由-N（R 2） - 表示的基团，R 2是氢或任选被羟基取代的C 1-6烃基或其盐。
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公开(公告)号：US08901160B2
公开(公告)日：2014-12-02
申请号：US14082440
申请日：2013-11-18
Applicant: Shiseido Company, Ltd.
Inventor： Shunsuke Iriyama , Hirotada Fukunishi , Masaru Suetsugu , Satoshi Amano
CPC classification number: A61K8/4946 , A61K8/49 , A61K2800/782 , A61Q19/02 , A61Q19/08
Abstract: A heparanase activity inhibitor comprising, as an active ingredient, a cyclic carboxamide derivative represented by formula (I): wherein n is an integer of 1 to 3, R1 is hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, X is —CH2— or a group represented by —N(R2)—, and R2 is hydrogen or a C1-6 hydrocarbon group optionally substituted with hydroxyl, or a salt thereof.
Abstract translation: 1.一种乙酰肝素酶活性抑制剂，其含有作为活性成分的式（I）表示的环状甲酰胺衍生物：其中n为1〜3的整数，R1为氢或任选被羟基取代的C 1-6烃基，X为 - CH 2 - 或由-N（R 2） - 表示的基团，R 2是氢或任选被羟基取代的C 1-6烃基或其盐。
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