METHODS OF DETERMINING AND USING A MICROBIOME RESILIENCE INDEX

    公开(公告)号:US20240282458A1

    公开(公告)日:2024-08-22

    申请号:US18687919

    申请日:2022-09-02

    IPC分类号: G16H50/30 G16H20/60

    CPC分类号: G16H50/30 G16H20/60

    摘要: Methods can quantify the degree of microbiota resilience of individuals with an index, in order to be able to propose a personalized nutrition solution to those who need it, to thereby improve their microbiome resilience, especially under challenges or stressors. Preferably, a resilience index is based on analysis of the microbiota before, during, and after a challenge with high fat diet, to provide a way of quantifying the resilience status of an individual's gut microbiome, on the basis of analysis of the microbiome's composition, metabolites and other physiological parameters, during and after the challenge. The microbiome resilience index can be used for clustering of consumers as resilient or non-resilient, so that dietary intervention can be proposed and/or administered to the non-resilient individuals. The present disclosure also provides a microbiome resistance index, a microbiome recovery index, and/or a microbiome resilience index; also provides a method to screen a patient that has a low resilience; and further provides a method to screen an individual with a low resilience index and provide a recommendation such as a nutritional intervention to the individual.