-
公开(公告)号：US20200339675A1
公开(公告)日：2020-10-29
申请号：US16793780
申请日：2020-02-18
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/28 , C07K14/705
Abstract: The present invention provides, inter alia, antibodies that modulate binding between Lrp5 and WISE or Lrp6 and WISE, but do not modulate binding between Lrp4 and WISE. Also provided are pharmaceutical compositions and kits containing such antibodies. Further provided are methods for preventing WISE binding to Lrp5 or Lrp6, but not WISE binding to Lrp4.
-
公开(公告)号：US20190194314A1
公开(公告)日：2019-06-27
申请号：US14653759
申请日：2013-12-20
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/28 , C07K14/705
CPC classification number: C07K16/28 , C07K14/705 , C07K2317/30 , C07K2317/76
Abstract: The present invention provides, inter alia, antibodies that modulate binding between Lrp5 and WISE or Lrp6 and WISE, but do not modulate binding between Lrp4 and WISE. Also provided are pharmaceutical compositions and kits containing such antibodies. Further provided are methods for preventing WISE binding to Lrp5 or Lrp6, but not WISE binding to Lrp4.
-
公开(公告)号：US09321835B2
公开(公告)日：2016-04-26
申请号：US14012626
申请日：2013-08-28
Applicant: Stowers Institute for Medical Research
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C07K14/47 , C07K14/705 , C12N5/12 , C12N15/13 , A61K38/00 , A61K48/00 , A61K39/00
CPC classification number: C07K16/22 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K2317/24 , C07K2317/92
Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.
Abstract translation: 本发明涉及分离的多肽和抗体，其适用于生产与骨沉积相关的治疗制剂，方法和试剂盒。 本发明的一个目的是提供改善骨沉积的组合物。 本发明的另一个目的是提供用于诊断骨骼失调的方法和组合物。 本发明的治疗组合物和方法与Wise，Sost和密切相关的序列的调控有关。 特别地，核酸序列和多肽包括Wise和Sost以及表达半胱氨酸结多肽的分子家族。
-
公开(公告)号：US09932393B2
公开(公告)日：2018-04-03
申请号：US14564979
申请日：2014-12-09
Applicant: Stowers Institute for Medical Research
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/18 , C07K16/26 , C07K14/47 , C07K14/705 , C07K16/30 , C07K14/575 , A61K38/00 , A61K48/00 , A61K39/00
CPC classification number: C07K16/18 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K14/705 , C07K16/30 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/626 , C07K2317/76
Abstract: The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.
-
公开(公告)号：US20130209474A1
公开(公告)日：2013-08-15
申请号：US13863939
申请日：2013-04-16
Applicant: Stowers Institute for Medical Research
Inventor： Robb KRUMLAUF , Debra Ellies
CPC classification number: C12N15/85 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K16/22 , G01N33/74 , Y02A50/481
Abstract: The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as a family of molecules which express a cysteine knot polypeptide. Additionally, the present invention relates to various molecular tools derived from the nucleic acids and polypeptides including vectors, transfected host cells, monochronal antibodies, Fab fragments, and methods for impacting the pathways.
-
Patent Agency Ranking
公开(公告)号：US09938341B2
公开(公告)日：2018-04-10
申请号：US15136776
申请日：2016-04-22
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Robb Krumlauf , Debra Ellies
CPC classification number: C07K16/22 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K2317/24 , C07K2317/92
Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.
-
公开(公告)号：US20240067718A1
公开(公告)日：2024-02-29
申请号：US18298105
申请日：2023-04-10
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/28 , A61K39/00 , C07K14/705
CPC classification number: C07K16/28 , A61K39/001102 , C07K14/705 , A61K39/001103 , A61K39/001116 , C07K2317/30 , C07K2317/76
Abstract: The present invention provides, inter alia, antibodies that modulate binding between Lrp5 and WISE or Lrp6 and WISE, but do not modulate binding between Lrp4 and WISE. Also provided are pharmaceutical compositions and kits containing such antibodies. Further provided are methods for preventing WISE binding to Lrp5 or Lrp6, but not WISE binding to Lrp4.
-
公开(公告)号：US20210301001A1
公开(公告)日：2021-09-30
申请号：US17071931
申请日：2020-10-15
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/18 , C07K14/47 , C07K14/705 , C07K16/30
Abstract: The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.
-
公开(公告)号：US20180222968A1
公开(公告)日：2018-08-09
申请号：US15942007
申请日：2018-03-30
Applicant: Stowers Institute for Medical Research
Inventor： Robb Krumlauf , Debra Ellies
IPC: C07K16/18 , C07K14/47 , C07K14/705 , C07K16/30 , C07K14/575 , A61K39/00 , A61K38/00 , A61K48/00
CPC classification number: C07K16/18 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/4702 , C07K14/575 , C07K14/705 , C07K16/30 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/626 , C07K2317/76
Abstract: The present invention relates to methods and compositions for the prevention and treatment of renal damage. The invention provides protein-based renal therapeutic agents for administration to subjects in order to prevent or treat renal degeneration or damage.
-
公开(公告)号：US20160289316A1
公开(公告)日：2016-10-06
申请号：US15136776
申请日：2016-04-22
Applicant: STOWERS INSTITUTE FOR MEDICAL RESEARCH
Inventor： Robb Krumlauf , Debra Ellies
CPC classification number: C07K16/22 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/4702 , C07K14/705 , C07K2317/24 , C07K2317/92
Abstract: The present invention is directed to isolated polypeptides and antibodies suitable for producing therapeutic preparations, methods, and kits relating to bone deposition. One objective of the present invention is to provide compositions that improve bone deposition. Yet another objective of the present invention is to provide methods and compositions to be utilized in diagnosing bone dysregulation. The therapeutic compositions and methods of the present invention are related to the regulation of Wise, Sost, and closely related sequences. In particular, the nucleic acid sequences and polypeptides include Wise and Sost as well as a family of molecules that express a cysteine knot polypeptide.
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.02 seconds)
