Hydrophobic active agent particle coatings and methods for treatment

    公开(公告)号:US11123459B2

    公开(公告)日:2021-09-21

    申请号:US15842110

    申请日:2017-12-14

    Abstract: Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.

    Delivery system for active agent coated balloon

    公开(公告)号:US10918835B2

    公开(公告)日:2021-02-16

    申请号:US15467530

    申请日:2017-03-23

    Inventor: Rick Murphy

    Abstract: Embodiments herein include delivery systems for active agent coated balloons and related methods. In an embodiment, a delivery system can include a tunneling sheath and a balloon catheter. The tunneling sheath can include a tubular shaft having an outer diameter and defining a lumen. The tunneling sheath can include a proximal collar defining a lumen. The balloon catheter can include a balloon catheter shaft disposed within the tubular shaft. The balloon catheter shaft can include a lumen for the passage of a fluid therein. The balloon catheter can include an expandable balloon disposed on the balloon catheter shaft. The balloon catheter shaft can include an active agent layer disposed on the expandable balloon. The position of the expandable balloon can be configured to be stationary relative to the tubular shaft as the delivery system is passed through a blood vessel of a patient. Other embodiments are also included herein.

    HYDROPHOBIC ACTIVE AGENT PARTICLE COATINGS AND METHODS FOR TREATMENT

    公开(公告)号:US20180169305A1

    公开(公告)日:2018-06-21

    申请号:US15842110

    申请日:2017-12-14

    Abstract: Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.

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