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    Compositions and methods for in vitro diagnostic tests including sulfonic acid compound
    2.
    发明授权
    Compositions and methods for in vitro diagnostic tests including sulfonic acid compound 有权
    用于体外诊断试验的组合物和方法，包括磺酸化合物

    公开(公告)号：US09229005B2

    公开(公告)日：2016-01-05

    申请号：US13849056

    申请日：2013-03-22

    申请人： SurModics, Inc.

    发明人： Gary Opperman ,  Wendy Nelson

    IPC分类号： G01N21/78 ,  C12Q1/28 ,  G01N33/58 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

    CPC分类号： G01N33/581 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

    摘要： The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.

    摘要翻译： 本发明提供用于进行比色分析的组合物，试剂盒和方法。 使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。 显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。 磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

    ARTICLE COATINGS INCLUDING OLIGOMERIZED POLYPHENOL LAYER AND BIOLOGICAL METHODS OF USE
    4.
    发明申请
    ARTICLE COATINGS INCLUDING OLIGOMERIZED POLYPHENOL LAYER AND BIOLOGICAL METHODS OF USE 审中-公开

    公开(公告)号：US20190275209A1

    公开(公告)日：2019-09-12

    申请号：US16272808

    申请日：2019-02-11

    申请人： Surmodics, Inc.

    发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

    IPC分类号： A61L29/08 ,  A61L27/34 ,  A61L29/06 ,  A61K31/7024 ,  G01N33/543 ,  A61L29/16

    摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

    KITS AND METHODS FOR IN VITRO ANALYTE DETECTION USING PRECIPITATING COMPOUND AND POLARIZERS
    5.
    发明申请
    KITS AND METHODS FOR IN VITRO ANALYTE DETECTION USING PRECIPITATING COMPOUND AND POLARIZERS 审中-公开
    使用预处理化合物和极化剂进行体内分析检测的试剂盒和方法

    公开(公告)号：US20140242575A1

    公开(公告)日：2014-08-28

    申请号：US14190367

    申请日：2014-02-26

    申请人： SurModics, Inc.

    发明人： Gary Opperman

    IPC分类号： G01N33/543

    CPC分类号： G01N33/582

    摘要： The invention provides inexpensive kits and methods for determination of an analyte in a sample with very high sensitivity. Analyte can be determined using an analyte binding member such as an antibody or an oligonucleotide, which can be directly or indirectly linked to an enzyme. The kit and method uses a compound that is altered in the presence of the enzyme, and that precipitates into crystalline particulates. The reaction composition with crystalline particulates is placed between two polarizers which are in an orthogonal arrangement, and the presence of particulates is observed, correlating to the analyte in the sample.

    摘要翻译： 本发明提供了用于以非常高的灵敏度测定样品中的分析物的便宜的试剂盒和方法。 可以使用可以直接或间接连接到酶的分析物结合成员例如抗体或寡核苷酸来测定分析物。 试剂盒和方法使用在酶存在下改变的化合物，并且沉淀成结晶微粒。 将具有结晶微粒的反应组合物放置在正交排列的两个偏振器之间，并且观察到与样品中的分析物相关的颗粒的存在。

    Article coatings including oligomerized polyphenol layer and biological methods of use
    7.
    发明授权
    Article coatings including oligomerized polyphenol layer and biological methods of use 有权

    公开(公告)号：US10201637B2

    公开(公告)日：2019-02-12

    申请号：US15502345

    申请日：2015-08-06

    申请人： SURMODICS, INC.

    发明人： David E. Babcock ,  Sean Lundquist ,  Gary Opperman ,  Adriyn Torguson ,  Tim Jentz

    IPC分类号： A61L29/08 ,  A61L29/06 ,  A61L29/16 ,  G01N33/543

    摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

    Compositions and methods for in vitro diagnostic tests including sulfonic acid
    8.
    发明授权
    Compositions and methods for in vitro diagnostic tests including sulfonic acid 有权
    用于体外诊断测试的组合物和方法，包括磺酸

    公开(公告)号：US08927226B2

    公开(公告)日：2015-01-06

    申请号：US14266143

    申请日：2014-04-30

    申请人： SurModics, Inc.

    发明人： Gary Opperman ,  Wendy Nelson

    IPC分类号： G01N33/58 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

    CPC分类号： G01N33/581 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

    摘要： The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.

    摘要翻译： 本发明提供用于进行比色分析的组合物，试剂盒和方法。 使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。 显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。 磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

    COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR IN VITRO DIAGNOSTIC TESTS INCLUDING SULFONIC ACID 有权
    用于体液检测的组合物和方法，包括硫酸

    公开(公告)号：US20140234874A1

    公开(公告)日：2014-08-21

    申请号：US14266143

    申请日：2014-04-30

    申请人： SurModics, Inc.

    发明人： Gary Opperman ,  Wendy Nelson

    IPC分类号： G01N33/58 ,  C12Q1/28

    CPC分类号： G01N33/581 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

    摘要： The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.

    摘要翻译： 本发明提供用于进行比色分析的组合物，试剂盒和方法。 使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。 显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。 磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。