公开(公告)号：US20030125484A1

公开(公告)日：2003-07-03

申请号：US10315512

申请日：2002-12-09

Applicant: Symyx Technologies, Inc.

Inventor： J. Christopher Freitag ,  Damian Hajduk ,  Ralph B. Nielsen ,  Adam Safir ,  Richard Tiede

IPC: C08F002/00

CPC classification number: B01J19/0046 ,  B01J2219/0029 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10S526/92 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: A method and apparatus for reacting a plurality of different mixtures in parallel in a semi-batch or continuous mode is provided. Each reaction is contained within a reactor vessel, the reactor vessels combined into a reactor block. Reactant(s) to be added during the reaction are kept in a header barrel, which has a plunger to feed reactant(s) from the header barrel through a transfer line into the reactor vessel. The plunger is moved using a drive system. The header barrels are optionally combined in a header block. The header block is sealed to a plate containing the transfer lines, which in turn is sealed to the reactor block. A latch mechanism is provided for easy sealing of the reactor and header blocks to the plate. The entire apparatus may be placed on a rocker or rotating plate for mixture as the reaction is proceeding.

Abstract translation: 提供了以半批或连续模式并行地进行多种不同混合物的方法和装置。 每个反应都包含在反应器容器中，反应器容器组合成反应器块。 在反应过程中加入的反应物保持在集管筒中，其具有柱塞，以通过输送管将反应物从集管筒送入反应器容器。 柱塞使用驱动系统移动。 标题桶可选地组合在标题块中。 集管块被密封到含有输送管线的板上，转移管路又与反应器块密封。 提供了一种闭锁机构，用于容易地将反应堆和集管块密封到板上。 当反应进行时，整个装置可以放置在摇臂或旋转板上用于混合。

公开(公告)号：US20020029621A1

公开(公告)日：2002-03-14

申请号：US09779149

申请日：2001-02-08

Applicant: Symyx Technologies, Inc.

Inventor： Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kolosov ,  James R. Engstrom ,  Adam Safir ,  Ravi Srinivasan ,  Leonid Matsiev

IPC: G01N003/48

CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

Abstract translation: 描述了通过测量单个文库成员对机械扰动的响应来筛选材料组合文库的装置和方法。 该装置通常包括用于容纳库构件的样本保持器，用于机械扰乱各个库构件的探针阵列，以及用于测量每个库构件对机械扰动的响应的传感器阵列。 正在进行筛选的图书馆成员组成一个样本数组，单独的图书馆成员构成了样本数组的元素，它们限于样本持有者的特定位置。 在筛选期间，设备通过移位样品阵列（样品架）和探针阵列来机械地干扰各个库成员。 通常，样本阵列的所有元素都被同时扰动，但是该装置也可以顺序扰乱单个或组的样本阵列元素。 灵活的装置和方法可以基于许多不同的体积物理性质（包括杨氏模量（挠曲，单轴延伸，双轴压缩和剪切））筛选材料库; 硬度（压痕），破坏（破坏时的应力和应变，韧性），粘附性（粘性，环粘性）和流动性（粘度，熔体流动指数和流变学）等。

公开(公告)号：US20020023507A1

公开(公告)日：2002-02-28

申请号：US09779148

申请日：2001-02-08

Applicant: Symyx Technologies, Inc.

Inventor： Damian Hajduk ,  Eric Carlson ,  J. Christopher Freitag ,  Oleg Kosolov

IPC: G01N003/48

CPC classification number: B01L3/5085 ,  B01J2219/00707 ,  B01J2219/00718 ,  G01N5/00 ,  G01N11/00 ,  G01N19/00 ,  G01N29/02 ,  G01N29/222 ,  G01N2203/0286 ,  G01N2291/02466 ,  G01N2291/0255 ,  G01N2291/02818 ,  G01N2291/106 ,  Y10T436/12

Abstract: An apparatus and method for screening combinatorial libraries of materials by measuring the response of individual library members to mechanical perturbations is described. The apparatus generally includes a sample holder for containing the library members, an array of probes for mechanically perturbing individual library members, and an array of sensors for measuring the response of each of the library members to the mechanical perturbations. Library members undergoing screening make up a sample array, and individual library members constitute elements of the sample array that are confined to specific locations on the sample holder. During screening, the apparatus mechanically perturbs individual library members by displacing the sample array (sample holder) and the array of probes. Typically, all of the elements of the sample array are perturbed simultaneously, but the apparatus also can also perturb individual or groups of sample array elements sequentially. The flexible apparatus and method can screen libraries of materials based on many different bulk physical properties, including Young's modulus (flexure, uniaxial extension, biaxial compression, and shear); hardness (indentation), failure (stress and strain at failure, toughness), adhesion (tack, loop tack), and flow (viscosity, melt flow indexing, and rheology), among others.

公开(公告)号：US20040211247A1

公开(公告)日：2004-10-28

申请号：US10799070

申请日：2004-03-12

Applicant: Symyx Technologies, Inc.

Inventor： Damian Hajduk ,  Paul Mansky

IPC: G01N011/06 ,  G01N011/08

CPC classification number: G01N11/06

Abstract: An apparatus and method for measuring viscosity or related properties of fluid samples in parallel is disclosed. The apparatus includes a plurality of tubes and reservoirs in fluid communication with the tubes. The tubes provide flow paths for the fluid samples, which are initially contained within the reservoirs. The apparatus also includes a mechanism for filling the reservoirs with the fluid samples, and a device for determining volumetric flow rates of fluid samples flowing from the reservoirs through the plurality of tubes simultaneously. The disclosed apparatus is capable of measuring viscosity or related properties of at least five fluid samples simultaneously. Useful reservoirs and tubes include syringes.

Abstract translation: 公开了一种并行测量流体样品的粘度或相关性质的装置和方法。 该装置包括与管流体连通的多个管和储存器。 管提供流体样品的流动路径，其最初包含在储存器内。 该装置还包括用于用流体样本填充储存器的机构，以及用于确定从贮存器同时流过多个管的流体样品的体积流量的装置。 所公开的装置能够同时测量至少五个流体样品的粘度或相关性质。 有用的储存器和管子包括注射器。

公开(公告)号：US20020148282A1

公开(公告)日：2002-10-17

申请号：US10104203

申请日：2002-03-22

Applicant: Symyx Technologies, Inc.

Inventor： Damian Hajduk ,  Paul Mansky

IPC: B05D001/00 ,  G01N011/06

CPC classification number: G01N11/06

Abstract: An apparatus and method for measuring viscosity or related properties of fluid samples in parallel is disclosed. The apparatus includes a plurality of tubes and reservoirs in fluid communication with the tubes. The tubes provide flow paths for the fluid samples, which are initially contained within the reservoirs. The apparatus also includes a mechanism for filling the reservoirs with the fluid samples, and a device for determining volumetric flow rates of fluid samples flowing from the reservoirs through the plurality of tubes simultaneously. The disclosed apparatus is capable of measuring viscosity or related properties of at least five fluid samples simultaneously. Useful reservoirs and tubes include syringes.

公开(公告)号：US20030033860A1

公开(公告)日：2003-02-20

申请号：US10261945

申请日：2002-10-01

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N011/10

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

公开(公告)号：US20030024302A1

公开(公告)日：2003-02-06

申请号：US10262369

申请日：2002-10-01

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N011/10

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

公开(公告)号：US20020194900A1

公开(公告)日：2002-12-26

申请号：US10205060

申请日：2002-07-25

Applicant: Symyx Technologies, Inc.

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N029/02

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

Abstract translation: 本发明涉及微型流变仪，平行流变仪和改进的力传感器元件，其可有利地与微型流变仪和平行流变仪组合使用。 微型流变仪适用于确定以少量样品形式提供的材料的流变特性。 微型流变仪包括致动元件，感测元件和反馈电路，以提供由样品施加到感测元件的剪切力的重新平衡，这确保了确定剪切应变的特殊刚度，以便允许高精度的测量。 本发明的并行流变仪允许多个样本的同时测量，以便在短时间内允许多个样本。 根据本发明的力传感器元件允许同时测量施加到传感器元件的剪切力和法向力。 此外，提供了一种流变仪，其包括基于应力光学材料的力传感器。

公开(公告)号：US20040242789A1

公开(公告)日：2004-12-02

申请号：US10881421

申请日：2004-06-29

Applicant: Symyx Technologies, Inc.

Inventor： Mingjun Liu ,  Damian Hajduk ,  Jean M.J. Frechet ,  Ezat Khoshdel ,  Ralph B. Nielsen ,  Dominique Charmot

IPC: C08L053/00 ,  C08F293/00

CPC classification number: C08F297/026 ,  C08F293/005 ,  C08F297/00 ,  C08F297/02 ,  C08F297/06

Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.

公开(公告)号：US20040093932A1

公开(公告)日：2004-05-20

申请号：US10712617

申请日：2003-11-12

Applicant: Symyx Technologies, Inc.

Inventor： Damian Hajduk ,  Eric Carlson ,  Ravi Srinivasan

IPC: G01N011/10 ,  G01N011/14 ,  G01N003/24

CPC classification number: G01N3/24 ,  G01N11/16 ,  G01N2203/0051 ,  G01N2203/0286 ,  G01N2203/0623

Abstract: The present invention relates to a miniature rheometer, a parallel rheometer, and improved force sensor elements which may advantageously be used in combination with the miniature rheometer and the parallel rheometer. The miniature rheometer is adapted to determine rheological characteristics of materials which are provided in the form of small quantity samples. The miniature rheometer comprises an actuating element, a sensing element and a feedback circuit to provide rebalance of the shear force applied by the sample to the sensing element, which insures an exceptional stiffness in determining the shear strain so as to allow measurements of high accuracy. The parallel rheometer of the present invention allows simultaneous measurements of a plurality of samples so as to allow of a plurality of samples within a short time period. The force sensor element according to the present invention allows simultaneous measurement of a shear force and a normal force applied to the sensor element. Moreover, a rheometer is provided which comprises a force sensor based on stress-optic material.

Abstract translation: 本发明涉及微型流变仪，平行流变仪和改进的力传感器元件，其可有利地与微型流变仪和平行流变仪组合使用。 微型流变仪适用于确定以少量样品形式提供的材料的流变特性。 微型流变仪包括致动元件，感测元件和反馈电路，以提供由样品施加到感测元件的剪切力的重新平衡，这确保了确定剪切应变的特殊刚度，从而允许高精度的测量。 本发明的并行流变仪允许多个样本的同时测量，以便在短时间内允许多个样本。 根据本发明的力传感器元件允许同时测量施加到传感器元件的剪切力和法向力。 此外，提供了一种流变仪，其包括基于应力光学材料的力传感器。