公开(公告)号：US20240253005A1

公开(公告)日：2024-08-01

申请号：US18614432

申请日：2024-03-22

Applicant: Oxford Nanopore Technologies PLC

Inventor： Jason Robert Hyde ,  Pedro Miguel Ortiz Bahamon ,  Clive Gavin Brown ,  Andrew John Heron ,  Paul Raymond Mackett

IPC: B01J19/00 ,  B01L3/00 ,  C12Q1/6869 ,  G01N33/487 ,  G01N33/573

CPC classification number: B01J19/0046 ,  B01L3/5088 ,  C12Q1/6869 ,  G01N33/48721 ,  G01N33/573 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00734 ,  B01J2219/00736 ,  B01L2200/0642 ,  B01L2400/086 ,  G01N2333/974

Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

公开(公告)号：US20240018507A1

公开(公告)日：2024-01-18

申请号：US18216054

申请日：2023-06-29

Applicant: Nutcracker Therapeutics, Inc.

Inventor： Benjamin Eldridge ,  Ximiao Wen

IPC: C12N15/10 ,  B01L3/00 ,  C12M1/36 ,  G01N21/01 ,  B01J19/00

CPC classification number: C12N15/101 ,  B01L3/502769 ,  C12M41/48 ,  G01N21/01 ,  B01J19/0046 ,  B01J19/0093 ,  B01L2400/0487 ,  G01N2021/0187 ,  B01J2219/00313 ,  B01J2219/00333 ,  B01J2219/00722 ,  B01J2219/00759

Abstract: Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

公开(公告)号：US20180169651A1

公开(公告)日：2018-06-21

申请号：US15783659

申请日：2017-10-13

Applicant: LABCYTE INC.

Inventor： Richard N. ELLSON

IPC: B01L3/00 ,  B01L3/02

CPC classification number: B01L3/50857 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00362 ,  B01L3/0244 ,  B01L3/0268 ,  B01L3/50855 ,  B01L2400/0436

Abstract: Provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.

公开(公告)号：US20160121155A1

公开(公告)日：2016-05-05

申请号：US14903105

申请日：2014-07-01

Applicant: Mark Julian WATERMAN

Inventor： Mark Julian WATERMAN

IPC: A63B19/04 ,  A63G1/14 ,  A63G1/08 ,  A63B21/00

CPC classification number: A63B19/04 ,  A63B21/4049 ,  A63G1/08 ,  A63G1/14 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00734 ,  B01J2219/00736 ,  B01L3/5088 ,  B01L2200/0642 ,  B01L2400/086 ,  G01N33/48721

Abstract: An activity frame comprising a first or outer ring mounted between a pair of opposed bearings in a opposed pair of supports, for example upstanding members of a frame, the first bearings having a having a first common axis; a second or middle ring mounted between opposed bearings on the first ring, the bearings having a second common axis orthogonal to the first common axis; a third or inner ring mounted between opposed bearings on the second ring, the bearings having a third common axis orthogonal to the second axis provided with demountable restraining means to limit the movement of two or more of the rings and demountable bars to fix one or more of the rings to the frame or other fixed object.

Abstract translation: 活动框架包括安装在相对的一对支撑件中的一对相对的轴承之间的第一或外圈，例如框架的直立构件，所述第一轴承具有第一公共轴线; 安装在所述第一环上的相对的轴承之间的第二或中间环，所述轴承具有与所述第一公共轴线正交的第二共同轴线; 安装在所述第二环上的相对的轴承之间的第三或内圈，所述轴承具有与所述第二轴线正交的第三共同轴线，所述第三共同轴线设置有可拆卸限制装置，以限制所述两个或多个所述环和可拆卸杆的移动以固定一个或多个 的环到框架或其他固定物体。

公开(公告)号：US09226346B2

公开(公告)日：2015-12-29

申请号：US12216294

申请日：2008-07-02

Applicant: Magnus Fagrell

Inventor： Magnus Fagrell

IPC: H05B6/68 ,  H05B6/64 ,  H05B6/80 ,  B01J19/00 ,  B01J19/12 ,  C40B60/14

CPC classification number: H05B6/806 ,  B01J19/0046 ,  B01J19/12 ,  B01J19/126 ,  B01J2219/00313 ,  B01J2219/00315 ,  B01J2219/00333 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0072 ,  B01J2219/1209 ,  B01J2219/1215 ,  B01J2219/1218 ,  C40B60/14 ,  H05B6/68 ,  Y02B40/143

Abstract: The present invention relates to an apparatus and methods for performing chemical reactions. In particular, the present invention relates to an apparatus for heating chemical reaction mixtures. The apparatus applies one or more semiconductor based microwave generators making the apparatus suitable for parallel processing of chemical reaction mixtures. The invention further relates to methods for performing chemical reactions, e.g. methods for heating a plurality of samples simultaneously or sequentially, methods for monitoring a microwave heated chemical reaction, and methods where the optimum conditions with respect to parameters, such frequency and applied power can be determined for the system consisting of apparatus plus sample.

公开(公告)号：US20150283531A1

公开(公告)日：2015-10-08

申请号：US14395002

申请日：2013-04-17

Applicant: BioFire Diagnostics, LLC

Inventor： David E. Jones ,  Kirk Max Ririe ,  Thomas Charles Robbins ,  Elizabeth Doman Copene ,  Charles Benjamin Cox

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00355 ,  B01J2219/00376 ,  B01J2219/00385 ,  B01J2219/00585 ,  B01J2219/00693 ,  B01L3/0262 ,  B01L3/0265 ,  B01L2200/16 ,  B01L2300/0861 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0478 ,  B01L2400/0487 ,  B01L2400/0605 ,  B01L2400/0616 ,  B01L2400/0655 ,  B01L2400/0677 ,  B01L2400/0683

Abstract: Devices and methods are provided for spotting an array with fluid. Arrays produced by such methods are also provided. In one aspect of the invention, a spotter device for spotting a plurality of fluids into an array is described, the spotter device comprising a plurality of reservoirs provided in a first configuration, each reservoir holding its respective fluid, a print head having a plurality of positions provided in a second configuration, the second configuration being different from the first configuration, a plurality of tubes, each tube configured to provide fluid communication from a reservoir at a first end of the tube to a position in the print head at the second end of the tube, and a pump for pumping fluid through the tubes from the reservoir to the print head.

Abstract translation: 提供了设备和方法，用于用流体点阵。 还提供了通过这些方法制备的阵列。 在本发明的一个方面，描述了一种用于将多种流体点样到阵列中的检测器装置，该定位装置包括设置在第一构型中的多个储存器，每个储存器保持其各自的流体，一个打印头具有多个 以第二配置提供的位置，第二配置不同于第一配置，多个管，每个管被配置为提供从管的第一端处的容器到第二端处的打印头中的位置的流体连通 的泵，以及用于将流体从储存器泵送到打印头的泵。

公开(公告)号：US20150126412A1

公开(公告)日：2015-05-07

申请号：US14301325

申请日：2014-06-10

Applicant: Massachusetts Institute of Technology

Inventor： Ian Hunter ,  Colin J.H. Brenan

IPC: B01J19/00 ,  G01N35/10

CPC classification number: B01J19/0046 ,  B01F13/0071 ,  B01F13/0084 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2200/0642 ,  C12Q1/34 ,  C40B60/14 ,  C40B70/00 ,  G01N21/75 ,  G01N35/00069 ,  G01N35/1002 ,  G01N2035/00237 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25

Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.

Abstract translation: 一种用于装载多个不同样本容器的方法和阵列填充系统，所述样本容器包括整体结构。 每个容器的特征在于亲水表面，并且容器由疏水表面分开。 该系统具有能够保持液体并适于运动的液体转移装置，以通过将液体拖过疏水表面而使保持在液体转移装置中的液体与阵列的连续容器顺序连通。

公开(公告)号：US20140272112A1

公开(公告)日：2014-09-18

申请号：US14142121

申请日：2013-12-27

Applicant: Intermolecular, Inc.

Inventor： Jeroen Van Duren ,  Minh Huu Le ,  Minh Anh Nguyen ,  Sandeep Nijhawan

IPC: C23C14/08 ,  C23C14/22 ,  C23C14/34

CPC classification number: H01L21/30 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00301 ,  B01J2219/00313 ,  B01J2219/0038 ,  B01J2219/00382 ,  B01J2219/00416 ,  B01J2219/00418 ,  B01J2219/00527 ,  B01J2219/00585 ,  B08B3/04 ,  C23C14/08 ,  C23C14/22 ,  C23C14/34 ,  C23C18/1619 ,  C23C18/1682 ,  C25D17/02 ,  G11C13/0004 ,  H01L21/02104 ,  H01L21/30604 ,  H01L21/67051 ,  H01L21/67057 ,  H01L21/6719 ,  H01L22/10 ,  H01L22/12 ,  H01L22/14 ,  H01L27/2463 ,  H01L45/1608

Abstract: Embodiments provided herein describe methods and systems for evaluating electrochromic material processing conditions. A substrate having a plurality of site-isolated regions defined thereon is provided. A first electrochromic material, or a first electrochromic device stack, is formed above a first of the plurality of site-isolated regions using a first set of processing conditions. A second electrochromic material, or a second electrochromic device stack, is formed above a second of the plurality of site-isolated regions using a second set of processing conditions. The second set of processing conditions is different than the first set of processing conditions.

Abstract translation: 本文提供的实施例描述了用于评估电致变色材料加工条件的方法和系统。 提供了具有限定在其上的多个位置隔离区域的基板。 使用第一组处理条件在多个位置隔离区域的第一个上方形成第一电致变色材料或第一电致变色器件堆叠。 使用第二组处理条件在多个位置隔离区域的第二个上方形成第二电致变色材料或第二电致变色器件堆叠。 第二组处理条件与第一组处理条件不同。

公开(公告)号：US20140051604A1

公开(公告)日：2014-02-20

申请号：US14057301

申请日：2013-10-18

Applicant: STOKES BIO LIMITED

Inventor： Mark Davies ,  Tara Dalton ,  Julie Garvey ,  Kieran Curran ,  Damian Curtin

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01F13/0071 ,  B01F15/0201 ,  B01F15/0232 ,  B01J2219/00313 ,  B01J2219/00353 ,  B01J2219/00479 ,  B01J2219/00587 ,  B01J2219/00608 ,  B01L3/5025 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2400/0487 ,  Y10T436/25

Abstract: A multi-port liquid bridge (1) adds aqueous phase droplets (10) in an enveloping oil phase carrier liquid (11) to a draft channel (4, 6). A chamber (3) links four ports, and it is permanently full of oil (11) when in use. Oil phase is fed in a draft flow from an inlet port (4) and exits through a draft exit port (6) and a compensating flow port (7). The oil carrier and the sample droplets (3) (“aqueous phase”) flow through the inlet port (5) with an equivalent fluid flow subtracted through the compensating port (7). The ports of the bridge (1) are formed by the ends of capillaries held in position in plastics housings. The phases are density matched to create an environment where gravitational forces are negligible. This results in droplets (10) adopting spherical forms when suspended from capillary tube tips. Furthermore, the equality of mass flow is equal to the equality of volume flow. The phase of the inlet flow (from the droplet inlet port (5) and the draft inlet port (4) is used to determine the outlet port (6) flow phase.

Abstract translation: 多端口液体桥（1）将包含油相载体液体（11）中的水相液滴（10）加入到通风道（4,6）。 室（3）连接四个端口，在使用时永久充满油（11）。 油相在进气口（4）的进料流中进料，并通过排气口（6）和补偿流通口（7）排出。 油载体和样品液滴（“水相”）以相当的流体流通过入口端口（5）流过补偿口（7）。 桥梁（1）的端口由保持在塑料壳体中的位置的毛细管的端部形成。 这些阶段是密度匹配的，以创造引力几乎可忽略的环境。 这导致当从毛细管尖端悬浮时，液滴（10）采用球形。 此外，质量流量的相等性等于体积流量的相等。 入口流（从液滴入口端口5和进气口4）的相位用于确定出口（6）的流动相位。

公开(公告)号：US08399383B2

公开(公告)日：2013-03-19

申请号：US09849781

申请日：2001-05-04

Applicant: Michael Snyder ,  Mark Reed ,  Heng Zhu ,  James Frank Klemic

Inventor： Michael Snyder ,  Mark Reed ,  Heng Zhu ,  James Frank Klemic

IPC: C40B40/02 ,  C40B40/10

CPC classification number: C12Q1/485 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00382 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/5085 ,  B82Y15/00 ,  B82Y30/00 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/543 ,  G01N33/54313 ,  G01N2500/00

Abstract: The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneously the presence, amount, and/or function of proteins present in a protein sample or on one protein chip, or to assay the presence, relative specificity, and binding affinity of each probe in a mixture of probes for each of the proteins on the chip. The invention also relates to methods of using the protein chips for high density and small volume chemical reactions. Also, the invention relates to polymers useful as protein chip substrates and methods of making protein chips. The invention further relates to compounds useful for the derivatization of protein chip substrates.