公开(公告)号：US20160076977A1

公开(公告)日：2016-03-17

申请号：US14888021

申请日：2013-09-18

Applicant: FREESLATE, INC.

Inventor： Stephen Lambert ,  John F. Varni ,  Gregor Hsiao

IPC: G01N1/10

CPC classification number: G01N1/10 ,  B01F13/0836 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00373 ,  B01J2219/00376 ,  B01J2219/00389 ,  B01J2219/00481 ,  C40B60/12 ,  C40B60/14 ,  G01N35/10 ,  G01N2001/105 ,  G01N2013/006

Abstract: Methods for sampling reactor contents in parallel reactor systems are disclosed. The methods may be used to sample reactor contents in non-atmospheric (e.g., pressurized) reaction vessels.

Abstract translation: 公开了在并联反应器系统中对反应器内容物进行取样的方法。 该方法可用于在非大气压（例如加压）的反应容器中对反应器内容物进行取样。

公开(公告)号：US08865475B2

公开(公告)日：2014-10-21

申请号：US13233279

申请日：2011-09-15

Applicant: Kazuhiro Chiba

Inventor： Kazuhiro Chiba

IPC: G01N1/18 ,  C07B61/00

CPC classification number: C07C231/12 ,  B01J2219/00308 ,  B01J2219/00364 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00686 ,  B01J2219/0072 ,  C07B61/00 ,  C07C67/10 ,  C07C231/02 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A method for making a number (N) of samples react under the same reaction conditions that includes heating a number of reaction containers simultaneously and maintaining the reaction containers at a predetermined temperature; placing a sample in each heated reaction chamber and maintaining a two-phase solution at a predetermined temperature; stirring the sample that is heated to the predetermined temperature to create a uniform solution, which is maintained for a predetermined time; and cooling the uniform solution without cooling the reaction container after the predetermined period of time has passed so as to gain a two-phase solution within the reaction container, where the samples have a solution where the phase state of a reaction solvent changes in a reversible manner between a two-phase solution state and a uniform solution state when the temperature fluctuates over or under a certain constant temperature.

Abstract translation: 制备数量（N）个样品的方法在相同的反应条件下反应，包括同时加热多个反应容器并将反应容器保持在预定温度; 将样品置于每个加热的反应室中并将两相溶液保持在预定温度; 搅拌加热至预定温度的样品以产生均匀的溶液，其保持预定时间; 并在经过预定时间后冷却均匀溶液而不冷却反应容器，从而获得反应容器内的两相溶液，其中样品具有反应溶剂的相态可逆地变化的溶液 当温度在某一恒定温度下波动时，两相溶液状态和均匀溶液状态之间的方式。

公开(公告)号：US20130184436A1

公开(公告)日：2013-07-18

申请号：US13649246

申请日：2012-10-11

Applicant: Nanjingjinsirui Science & Technology Biology Corporation

Inventor： Zhuying WANG ,  Jinyu YANG ,  Wenyu XU ,  Tao BAI

IPC: B01J19/18 ,  B01J19/24 ,  C07K1/06

CPC classification number: C40B50/14 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00288 ,  B01J2219/0036 ,  B01J2219/00416 ,  B01J2219/00481 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00684 ,  B01J2219/00689 ,  B01J2219/00725 ,  C07K1/047

Abstract: An apparatus is provided for the semi-automated parallel synthesis of multiple peptides. The apparatus includes an array of nozzles, each positioned above or adjacent a separate reaction container, two or more liquid reservoirs, each reservoir coupled to the liquid dispenser(s), and base chamber(s) connected to the reaction containers for removing liquid there from. The addition and removal of liquids may be controlled by programmable electromagnetic valves. The apparatus may also be used for other parallel solid phase reactions. A method is also provided for synthesizing multiple polypeptides or other macromolecules, for example by using the above apparatus, wherein multiple common steps are performed automatically while reactants are added manually.

Abstract translation: 提供了一种用于多自由体并行合成多肽的装置。 该设备包括一组喷嘴，每个喷嘴均位于或邻近单独的反应容器，两个或多个液体储存器，每个储存器联接到液体分配器，以及连接到反应容器的基室，用于去除液体 从。 液体的添加和除去可以由可编程电磁阀来控制。 该装置也可用于其它平行固相反应。 还提供了用于合成多种多肽或其它大分子的方法，例如通过使用上述装置，其中在手动添加反应物的情况下自动执行多个常见步骤。

公开(公告)号：US20130157897A1

公开(公告)日：2013-06-20

申请号：US13327352

申请日：2011-12-15

Applicant: Aaron Francis ,  Gregory Lim

Inventor： Aaron Francis ,  Gregory Lim

IPC: C40B40/00

CPC classification number: B01F13/0818 ,  B01F13/1022 ,  B01F15/00454 ,  B01F15/00733 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00481

Abstract: A system for combinatorially processing a substrate is provided. The system includes a reactor or chemical library having a plurality of chambers defined within the reactor or library, the chambers operable to mix fluids disposed therein. A drive system is disposed below a bottom surface of the reactor. The drive system is operable to rotate a plurality of support plates below the surface of the substrate. The plurality of support plates has a non-circular shape. The non-circular shape of adjacent support plates includes extensions configured to traverse overlapping regions of rotation during rotation of adjacent support plates. Each of the extensions has a magnet disposed thereon.

Abstract translation: 提供了一种用于组合处理衬底的系统。 该系统包括具有限定在反应器或库内的多个室的反应器或化学库，所述室可操作以混合设置在其中的流体。 驱动系统设置在反应器底面的下方。 驱动系统可操作以将多个支撑板旋转到基板的表面下方。 多个支撑板具有非圆形形状。 相邻支撑板的非圆形形状包括构造成在相邻的支撑板的旋转期间横过重叠的旋转区域的延伸部。 每个延伸部具有设置在其上的磁体。

公开(公告)号：US07960313B2

公开(公告)日：2011-06-14

申请号：US11763180

申请日：2007-06-14

Applicant: Zachary Fresco ,  Nitin Kumar

Inventor： Zachary Fresco ,  Nitin Kumar

IPC: C40B60/14 ,  C40B60/00 ,  B01L3/00 ,  B01L99/00

CPC classification number: B01J19/0046 ,  B01J2219/00333 ,  B01J2219/00364 ,  B01J2219/00389 ,  B01J2219/00481 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00756

Abstract: Combinatorial processing including stirring is described, including defining multiple regions of a substrate, processing the multiple regions of the substrate in a combinatorial manner, introducing a fluid into a first aperture at a first end of a body to dispense the fluid out of a second aperture at a second end of the body and into one of the multiple regions, and agitating the fluid using an impeller at a second end of the body to facilitate interaction of the fluid with a surface of the substrate.

Abstract translation: 描述了包括搅拌在内的组合处理，包括限定衬底的多个区域，以组合的方式处理衬底的多个区域，将流体引入到身体的第一端的第一孔中，以将流体从第二孔 在所述主体的第二端并且进入所述多个区域之一，并且在所述主体的第二端处使用叶轮来搅动所述流体，以促进所述流体与所述基板的表面的相互作用。

公开(公告)号：US20110027144A1

公开(公告)日：2011-02-03

申请号：US12901941

申请日：2010-10-11

Applicant: Masatoshi Shibata ,  Yutaka Mashiyama ,  Yasuyuki Suzuki ,  Isamu Hiruta ,  Toshiaki Wada ,  Tetsuo Tomoda

Inventor： Masatoshi Shibata ,  Yutaka Mashiyama ,  Yasuyuki Suzuki ,  Isamu Hiruta ,  Toshiaki Wada ,  Tetsuo Tomoda

IPC: B01J19/18 ,  B01J19/00

CPC classification number: B01J19/0046 ,  B01F7/001 ,  B01F7/00116 ,  B01F7/00141 ,  B01F7/003 ,  B01F7/00558 ,  B01F13/0827 ,  B01F13/089 ,  B01J2219/00283 ,  B01J2219/00346 ,  B01J2219/00389 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0072

Abstract: To provide an organic synthesizer that can conduct a pressure reaction and an atmospheric reaction in one organic synthesizer and can realize attachment of reaction vessels to the organic synthesizer and detachment of the reaction vessels from the organic synthesizer without applying any load to gas supply/discharge pipes.[Means For Solving Problems] An organic synthesizer comprising a reaction vessel support part (160), which can support two or more reaction vessels, and pressure regulation means (164) for regulating the pressure within the reaction vessel supported by the reaction vessel support part (160) by supplying/discharging gas. Two or more pressure regulation means (164) are provided for each reaction vessel supported by the reaction vessel support part (160). At least one pressure regulation means (164A) in the two or more pressure regulation means (164) is constructed so as to be detachable from and attachable to the other pressure regulation means (164B). The pressure regulation means (164) comprises gas supply/discharge pipes (174a to 174d) and openings (194a to 174d) for supporting the gas supply/discharge pipes (174a to 174d). The gas supply/discharge pipes (174a to 174d) are constructed so that a part near the front end can be flexed in a vertical direction and in a lateral direction and are connected to the supported reaction vessels for gas supply and discharge.

Abstract translation: 提供一种能够在一种有机合成仪中进行压力反应和大气反应的有机合成仪，并且可以实现反应容器与有机合成仪的连接，并使反应容器与有机合成仪分离，而不对气体供给/排出管施加任何负荷 。 解决问题的手段一种有机合成装置，包括可支撑两个或多个反应容器的反应容器支撑部分（160）和用于调节由反应容器支撑部分支撑的反应容器内的压力的压力调节装置（164） （160）通过供给/排出气体。 为由反应容器支撑部分（160）支撑的每个反应容器提供两个或更多个压力调节装置（164）。 两个或更多个压力调节装置（164）中的至少一个压力调节装置（164A）构造成可拆卸并附接到另一压力调节装置（164B）。 压力调节装置（164）包括用于支撑供气/排出管（174a至174d）的气体供给排出管（174a至174d）和开口（194a至174d）。 气体供给排出管174a〜174d构成为能够使前端附近的部分在垂直方向和横向上弯曲并且与支撑的气体供给和排出的反应容器连接。

公开(公告)号：US07807109B2

公开(公告)日：2010-10-05

申请号：US11803349

申请日：2007-05-14

Applicant: Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

Inventor： Gary M. Diamond ,  Keith A. Hall ,  Thomas Harding McWaid ,  Vince Murphy ,  Michael Myslovaty ,  James A. W. Shoemaker ,  Robbie Singh Sidhu ,  Howard Turner ,  Eric Dias ,  Mikhail Spitkovsky

IPC: G05D16/00 ,  B01J19/00

CPC classification number: C40B60/08 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00319 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00693 ,  B01J2219/00698 ,  B01J2219/0072 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00747

Abstract: Described is a parallel batch reactor for effecting chemical reactions. The parallel batch reactor includes a plurality of reactor vessels for receiving components of a reaction, an inlet port for receiving pressurized fluid, and a plurality of valves configured to transfer fluid from the inlet port to the reactor vessels and fluidically isolate one or more of the reactor vessels from at least one of the other reactor vessels. The reactor further includes a pressure monitoring system comprising an array of pressure sensors configured to sense pressure in the reactor vessels. Each of the pressure sensors is aligned with one of the plurality of reactor vessels and located external to the reactor vessels and fluid passageways in fluid communication with the reactor vessels.

Abstract translation: 描述了用于进行化学反应的平行间歇反应器。 并联反应器包括用于接收反应组分的多个反应器容器，用于接收加压流体的入口端口和多个阀，所述多个阀被配置成将流体从入口传送到反应器容器并且流体地隔离一个或多个 来自至少一个其他反应器容器的反应器容器。 反应器还包括压力监测系统，其包括被配置为感测反应器容器中的压力的​​压力传感器阵列。 每个压力传感器与多个反应器容器中的一个对准并且位于反应器容器外部和与反应器容器流体连通的流体通道。

公开(公告)号：US07569196B2

公开(公告)日：2009-08-04

申请号：US10579471

申请日：2004-09-16

Applicant: Horst-Werner Zanthoff ,  Dietrich Maschmeyer ,  Thorsten Schwärtzke ,  Udo Robers ,  Anita Völkel

Inventor： Horst-Werner Zanthoff ,  Dietrich Maschmeyer ,  Thorsten Schwärtzke ,  Udo Robers ,  Anita Völkel

IPC: B01J7/02 ,  B01J8/00 ,  B01D21/00 ,  B01D25/32 ,  B01D24/00

CPC classification number: B01J8/006 ,  B01F7/00641 ,  B01J8/085 ,  B01J8/087 ,  B01J8/10 ,  B01J8/222 ,  B01J19/0046 ,  B01J19/0066 ,  B01J2208/0007 ,  B01J2219/00011 ,  B01J2219/00033 ,  B01J2219/00038 ,  B01J2219/002 ,  B01J2219/00213 ,  B01J2219/00231 ,  B01J2219/00236 ,  B01J2219/00283 ,  B01J2219/00389 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00707 ,  B01J2219/00736 ,  B01J2219/00738 ,  B01J2219/00747

Abstract: A reactor for carrying out catalyzed liquid reactions in which the catalyst is present as a dispersion in the reaction zone. The reactor includes at least one inlet and outlet, with all starting materials being fed in via the inlet and all products being discharged via the outlet. The inlet and outlet can be switched so that an exit previously serving as the outlet is utilized as an entrance serving as the inlet and at the same time an entrance previously serving as the inlet is utilized as an exit serving as the outlet. The inlet and outlet each include a filter element that keeps the catalyst in the reactor. The reactor also includes a device that ensures homogeneous distribution of the catalyst and the starting materials in the reactor. This reactor can carry out reactions at a high solids content without the catalyst having to be separated off from a product stream in an extra process step and without regular cleaning and thus shutdown of the process being necessary.

Abstract translation: 用于进行催化液体反应的反应器，其中催化剂作为反应区中的分散体存在。 反应器包括至少一个入口和出口，所有原料通过入口进料，所有的产物通过出口排出。 入口和出口可以被切换，使得先前用作出口的出口被用作入口用作入口，并且同时将先前用作入口的入口用作出口用作出口。 入口和出口各自包括将催化剂保持在反应器中的过滤元件。 反应器还包括确保催化剂和原料在反应器中均匀分布的装置。 该反应器可以以高固体含量进行反应，而不需要在额外的工艺步骤中将催化剂从产物流中分离出来，并且不需要定期清洁，因此关闭所需的方法。

公开(公告)号：US20080153716A1

公开(公告)日：2008-06-26

申请号：US12072364

申请日：2008-02-26

Applicant: Robert H. Wollenberg ,  Thomas J. Balk

Inventor： Robert H. Wollenberg ,  Thomas J. Balk

IPC: C40B60/14 ,  C40B70/00

CPC classification number: B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00364 ,  B01J2219/00481 ,  B01J2219/00486 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/00704 ,  B01J2219/00756 ,  G01N33/30 ,  Y10T436/12 ,  Y10T436/25

Abstract: A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided. The methods can advantageously be optimized using combinatorial chemistry, in which a database of combinations of lubricating oil compositions are generated. As market conditions vary and/or product requirements or customer specifications change, conditions suitable for forming desired products can be identified with little or no downtime.

公开(公告)号：US20070231223A1

公开(公告)日：2007-10-04

申请号：US11710137

申请日：2007-02-23

Applicant: Li Young

Inventor： Li Young

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00344 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00416 ,  B01J2219/00481 ,  B01J2219/00493 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/0072

Abstract: A system and a methodology for controlling multifunctional multireactor chemical synthesis instruments employ real time automatic controls, calculations, feedbacks and optional graphic tracking of parameters, process characteristics and events and offer templates for designing otherwise complex sequences for the bench chemist, physicist or biologist. Automatic lab notebook construction is also provided as well as remote monitoring and control options, warning alarms and shut down alarms.

Abstract translation: 用于控制多功能多反应器化学合成仪器的系统和方法采用实时自动控制，计算，反馈和可选的参数，过程特性和事件的图形跟踪，并提供用于为台式化学家，物理学家或生物学家设计其他复杂序列的模板。 还提供自动实验室笔记本结构，以及远程监控和控制选项，警告报警和关闭报警。