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    SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS
    1.
    发明申请
    SYNERGISTIC ACTIVE PREPARATIONS COMPRISING DIPHENYLMETHANE DERIVATIVES AND FURTHER SKIN AND/OR HAIR LIGHTENING AND/OR SENILE KERATOSIS REDUCING COMPOUNDS 审中-公开
    包含二苯基甲基衍生物的协同活性制剂和进一步的皮肤和/或头发亮度和/或高效减毒化合物

    公开(公告)号：US20090148391A1

    公开(公告)日：2009-06-11

    申请号：US12159951

    申请日：2007-01-05

    申请人： Gerhard Schmaus ,  Sabine Lange ,  Gabriele Vielhaber ,  Karin Schaper ,  Ravikumar Pillai

    发明人： Gerhard Schmaus ,  Sabine Lange ,  Gabriele Vielhaber ,  Karin Schaper ,  Ravikumar Pillai

    IPC分类号： A61K8/97 ,  A61K31/05 ,  A61Q17/04 ,  A61K36/48

    CPC分类号： A61K8/347 ,  A61K8/35 ,  A61K2800/52 ,  A61K2800/782 ,  A61Q5/08 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q19/08

    摘要： The present invention relates to specific synergistic active skin- and/or hair-lightening and/or senile keratosis-reducing (cosmetic or pharmaceutical) preparations comprising a mixture comprising or consisting of a) a tyrosinase-inhibiting amount of one or more compounds of the formula 1:  wherein: R1 is hydrogen, methyl, straight-chain or branched alkyl having 2-4 C atoms, OH or halogen, R2 is hydrogen, methyl or straight-chain or branched alkyl having 2-5 C atoms, R3 is methyl or straight-chain or branched alkyl having 2-5 C atoms, and R4 and R5 are, independently of one another hydrogen, methyl, straight-chain or branched alkyl having 2-5 C atoms, OH or halogen and b) a skin- and/or hair lightening and/or senile keratosis-reducing amount of one or more compounds selected from the group consisting of (i) chelating agents, (ii) phenolic derivatives, plant extracts with an amount of phenolic derivatives and (iii) organic acid derivatives as well as uses thereof.

    摘要翻译： 本发明涉及具体的协同增效活性皮肤和/或发发轻度和/或老年角化病减少剂（化妆品或药物）制剂，其包含混合物，其包含或由以下组成：a）酪氨酸酶抑制量的一种或多种化合物 式1：其中：R1是氢，甲基，具有2-4个C原子的直链或支链烷基，OH或卤素，R2是氢，甲基或具有2-5个C原子的直链或支链烷基，R3是甲基 或具有2-5个C原子的直链或支链烷基，R 4和R 5彼此独立地为具有2-5个C原子的氢，甲基，直链或支链烷基，OH或卤素，和b） 和/或毛发发光和/或老年性角化病减少量的一种或多种选自（i）螯合剂，（ii）酚衍生物，具有一定量酚衍生物的植物提取物和（iii）有机酸 衍生物及其用途。

    STABILIZED PREPARATIONS COMPRISING PHENOLIC COMPOUNDS AND BENZOPHENONES
    2.
    发明申请
    STABILIZED PREPARATIONS COMPRISING PHENOLIC COMPOUNDS AND BENZOPHENONES 审中-公开
    包含苯酚化合物和苯并噻唑的稳定化制剂

    公开(公告)号：US20090130035A1

    公开(公告)日：2009-05-21

    申请号：US12159866

    申请日：2007-01-05

    申请人： Sabine Lange ,  Gerhard Schmaus ,  Gabriele Vielhaber ,  Karin Schaper

    发明人： Sabine Lange ,  Gerhard Schmaus ,  Gabriele Vielhaber ,  Karin Schaper

    IPC分类号： A61K8/35 ,  A61K31/12 ,  C07C49/215

    CPC分类号： A61K8/347 ,  A61K8/35 ,  A61K2800/52 ,  A61K2800/782 ,  A61Q5/08 ,  A61Q17/04 ,  A61Q19/02 ,  A61Q19/08

    摘要： The present invention relates primarily to a cosmetic and/or pharmaceutical preparation comprising of consisting of one or more phenolic compounds of the formula (I) where for formula (I) it is the case that: R1, R2, R3, R4 and R5 are independently of one another hydrogen, halogen, an OH group, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, with 1, 2 or 3 different radicals from the group R1, R2, R3, R4 and R5 simultaneously representing an OH group, R6 and R7 are independently of one another hydrogen, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, n is an integer from 0 to 20 and R8 is methyl or a linear or branched alkyl having 2 or 3 C atoms, a cycloalkyl having 3, 4, 5, 6 or 7 C atoms or a phenyl and one or more compounds of the formula (II) where for formula (II) it is the case that: R9, R10, R11 and R12 independently of one another are hydrogen, methyl, an OH group or a group —O—R13 and R13 is methyl or a linear or branched alkyl having 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, and to uses of compounds of the formula (II) for stabilizing compounds of the formula (I), and also to methods of stabilizing compounds of the formula (I).

    摘要翻译： 本发明主要涉及包含一种或多种式（I）的酚类化合物的化妆品和/或药物制剂，其中对于式（I），其中R1，R2，R3，R4和R5是 独立于氢，卤素，OH基，甲基或具有2,3,4或5个C原子的直链或支链烷基，与R1，R2，R3，R4和R5中的1,2或3个不同的基团 同时表示OH基团，R6和R7彼此独立地为氢，甲基或具有2,3,4或5个C原子的直链或支链烷基，n为0至20的整数，R8为甲基或直链或支链烷基， 具有2或3个C原子的支链烷基，具有3,4,5,6或7个C原子的环烷基，或苯基和一种或多种式（II）化合物，其中式（II）的情况是：R9 R 10，R 11和R 12彼此独立地是氢，甲基，OH基或-O-R 13基，R 13是甲基或具有2,3， 4，5，6，7，8，9或10个C原子，以及式（II）化合物用于稳定式（I）化合物的用途，以及稳定式（I）化合物的方法， 。

    Antimicrobially active compounds for treating bad breath
    5.
    发明申请
    Antimicrobially active compounds for treating bad breath 审中-公开
    用于治疗口臭的抗微生物活性化合物

    公开(公告)号：US20080008660A1

    公开(公告)日：2008-01-10

    申请号：US11812085

    申请日：2007-06-14

    申请人： Jurgen Rabenhorst ,  Arnold Machinek ,  Gerhard Schmaus ,  Martina Herrmann ,  Gabriele Vielhaber ,  Ravikumar Pillai

    发明人： Jurgen Rabenhorst ,  Arnold Machinek ,  Gerhard Schmaus ,  Martina Herrmann ,  Gabriele Vielhaber ,  Ravikumar Pillai

    IPC分类号： A61K8/30 ,  A61K31/16 ,  A61Q11/00

    CPC分类号： A61K31/16 ,  A61K8/42 ,  A61Q11/00

    摘要： The invention relates primarily to specific uses of a compound of the Formula 1 or of mixtures of two or more different compounds of the Formula 1, in particular for producing an antimicrobially acting agent and agent against bad breath, as well as the corresponding production methods. In addition the invention relates to specific products, in particular oral hygiene products, comprising or consisting of a compound of the Formula 1 or of a mixture of two or more different compounds of the Formula 1 wherein the radicals of the compound of the Formula 1 or of each compound of the Formula 1 in the mixture are as defined in the preceding description.

    摘要翻译： 本发明主要涉及式1化合物或两种或多种不同式1化合物的混合物的具体用途，特别是用于生产抗微生物作用剂和抗口臭药物以及相应的生产方法。 此外，本发明涉及特定的产品，特别是口服卫生产品，其包含式I化合物或由式1的两种或更多种不同化合物的混合物组成或由其组成，其中式1化合物或 的混合物中式1的每种化合物如前述描述中所定义。

    Menthyl carbamate compounds as skin and/or hair lightening actives
    7.
    发明授权
    Menthyl carbamate compounds as skin and/or hair lightening actives 有权
    叶酸氨基甲酸酯化合物作为皮肤和/或发亮活性物质

    公开(公告)号：US09060949B2

    公开(公告)日：2015-06-23

    申请号：US13699543

    申请日：2010-05-25

    申请人： Gabriele Vielhaber ,  Heiko Oertling ,  Karin Schaper ,  Claudia Gömann ,  Rahim Brodhage

    发明人： Gabriele Vielhaber ,  Heiko Oertling ,  Karin Schaper ,  Claudia Gömann ,  Rahim Brodhage

    IPC分类号： A61Q19/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61K8/40 ,  A61K8/44 ,  A61K31/325 ,  A61Q5/08 ,  A61K8/49 ,  A61Q5/00 ,  A61Q17/00

    CPC分类号： A61K8/40 ,  A61K8/44 ,  A61K8/4973 ,  A61K31/325 ,  A61Q5/00 ,  A61Q5/08 ,  A61Q17/00 ,  A61Q19/02

    摘要： The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).

    摘要翻译： 本发明涉及式（I）化合物或式（I）化合物的化妆品可接受的盐或包含两种或更多种这些化合物或其盐的混合物的化妆品，皮肤病学或药学（治疗）用途，其中 R 1表示氢或碳原子数为1〜14的有机基团，R 2表示碳原子数1〜14的有机基团，且R 1和R 2中任选具有共价键，优选形成3〜8元环 ，用于减轻皮肤和/或头发。 本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式（I）化合物的组合物和化妆品，皮肤病学或药物制剂（组合物）。 本发明还涉及作为药物的式（I）化合物，其用于制备用于减轻人类皮肤和/或头发的药物组合物和某些新的式（I）化合物的用途。

    MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
    8.
    发明申请
    MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES 有权
    MENTHYL CARBAMATE化合物作为皮肤和/或头发照明活动

    公开(公告)号：US20130129646A1

    公开(公告)日：2013-05-23

    申请号：US13699543

    申请日：2010-05-25

    申请人： Gabriele Vielhaber ,  Heiko Oertling ,  Karin Schaper ,  Claudia Gömann ,  Rahim Brodhage

    发明人： Gabriele Vielhaber ,  Heiko Oertling ,  Karin Schaper ,  Claudia Gömann ,  Rahim Brodhage

    IPC分类号： A61K8/40 ,  A61Q5/00 ,  A61Q17/00 ,  A61K8/49 ,  A61Q19/02

    CPC分类号： A61K8/40 ,  A61K8/44 ,  A61K8/4973 ,  A61K31/325 ,  A61Q5/00 ,  A61Q5/08 ,  A61Q17/00 ,  A61Q19/02

    摘要： The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).

    摘要翻译： 本发明涉及式（I）化合物或式（I）化合物的化妆品可接受的盐或包含两种或更多种这些化合物或其盐的混合物的化妆品，皮肤病学或药学（治疗）用途，其中 R 1表示氢或碳原子数为1〜14的有机基团，R 2表示碳原子数1〜14的有机基团，且R 1和R 2中任选具有共价键，优选形成3〜8元环 ，用于减轻皮肤和/或头发。 本发明还涉及包含一种或多种适合于减轻人类皮肤和/或头发的相应方法的式（I）化合物的组合物和化妆品，皮肤病学或药物制剂（组合物）。 本发明还涉及作为药物的式（I）化合物，其用于制备用于减轻人类皮肤和/或头发的药物组合物和某些新的式（I）化合物的用途。

    Use of Glycosylated Flavanones for the Browning of Skin or Hair
    9.
    发明申请
    Use of Glycosylated Flavanones for the Browning of Skin or Hair 审中-公开
    使用糖基化的黄烷酮对皮肤或头发的褐变

    公开(公告)号：US20080305054A1

    公开(公告)日：2008-12-11

    申请号：US11577846

    申请日：2005-10-21

    申请人： Gabriele Vielhaber ,  Karin Schaper ,  Martina Herrmann

    发明人： Gabriele Vielhaber ,  Karin Schaper ,  Martina Herrmann

    IPC分类号： A61K8/49 ,  A61Q5/10 ,  A61Q17/04

    CPC分类号： A61K8/602 ,  A61K8/498 ,  A61Q5/065 ,  A61Q19/04

    摘要： The use of a compound having formula (I) is described as an agent for the browning of skin or hair, Formula (I) wherein: R1 and R2 are mutually independently H, OH, C1-C10-alkyl, C1-C10-O-alkyl or O-prenyl, R3 is H, OH, O-glucose or O-rhamnose and R4 is a monosaccharide radical or an oligosaccharide radical having 2, 3, 4 or 5 carbohydrate units, with the proviso that the compound having formula (I) is not used in the form of a preparation based on Citrus auranitium dulcis.

    摘要翻译： 描述了具有式（I）化合物作为皮肤或毛发褐变的试剂，式（I）其中：R 1和R 2彼此独立地为H，OH，C 1 -C 10 - 烷基，C 1 -C 10 -O - 烷基或O-异戊烯基，R 3是H，OH，O-葡萄糖或O-鼠李糖，R4是具有2,3,4或5个碳水化合物单元的单糖基团或寡糖基团，条件是具有式 I）不以基于Citrus auranitium dulcis的制剂的形式使用。