公开(公告)号：US09006230B2

公开(公告)日：2015-04-14

申请号：US14113980

申请日：2012-08-24

申请人： Sachin Bhagwat ,  Prasad Keshav Deshpande ,  Satish Bhawsar ,  Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Shivaji Sampatrao Pawar ,  Sunil Bhaginath Jadhav ,  Sanjay Kisan Dabhade ,  Vikas Vitthalrao Deshmukh ,  Bharat Dond ,  Satish Birajdar ,  Mohammad Usman Shaikh ,  Deepak Dekhane ,  Piyush Ambalal Patel

发明人： Sachin Bhagwat ,  Prasad Keshav Deshpande ,  Satish Bhawsar ,  Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Shivaji Sampatrao Pawar ,  Sunil Bhaginath Jadhav ,  Sanjay Kisan Dabhade ,  Vikas Vitthalrao Deshmukh ,  Bharat Dond ,  Satish Birajdar ,  Mohammad Usman Shaikh ,  Deepak Dekhane ,  Piyush Ambalal Patel

IPC分类号： A61K31/00 ,  C07D233/10 ,  C07D243/00 ,  C07D471/08 ,  A61K31/424 ,  A61K31/43 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/546 ,  C07D519/00 ,  C07D498/04

CPC分类号： C07D471/08 ,  A61K31/424 ,  A61K31/43 ,  A61K31/431 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/546 ,  A61K45/06 ,  C07D498/04 ,  C07D519/00 ,  A61K2300/00

摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

摘要翻译： 公开了式（I）化合物及其制备和用于预防或治疗细菌感染的方法。

公开(公告)号：US20140088068A1

公开(公告)日：2014-03-27

申请号：US14113980

申请日：2012-08-24

申请人： Sachin Bhagwat ,  Prasad Keshav Deshpande ,  Satish Bhawsar ,  Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Shivaji Sampatrao Pawar ,  Sunil Bhaginath Jadhav ,  Sanjay Kisan Dabhade ,  Vikas Vitthalrao Deshmukh ,  Bharat Dond ,  Satish Birajdar ,  Mohammad Usman Shaikh ,  Deepak Dekhane ,  Piyush Ambalal Patel

发明人： Sachin Bhagwat ,  Prasad Keshav Deshpande ,  Satish Bhawsar ,  Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Shivaji Sampatrao Pawar ,  Sunil Bhaginath Jadhav ,  Sanjay Kisan Dabhade ,  Vikas Vitthalrao Deshmukh ,  Bharat Dond ,  Satish Birajdar ,  Mohammad Usman Shaikh ,  Deepak Dekhane ,  Piyush Ambalal Patel

IPC分类号： C07D471/08 ,  A61K31/43 ,  A61K31/424 ,  A61K31/496 ,  A61K31/439 ,  C07D519/00 ,  A61K31/5383 ,  A61K31/5377 ,  A61K31/4545 ,  A61K31/546

CPC分类号： C07D471/08 ,  A61K31/424 ,  A61K31/43 ,  A61K31/431 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/546 ,  A61K45/06 ,  C07D498/04 ,  C07D519/00 ,  A61K2300/00

摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

摘要翻译： 公开了式（I）化合物及其制备和用于预防或治疗细菌感染的方法。

公开(公告)号：US09127004B2

公开(公告)日：2015-09-08

申请号：US14298182

申请日：2014-06-06

申请人： Sachin Bhagwat ,  Prasad Keshav Deshpande ,  Satish Bhawsar ,  Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Shivaji Sampatrao Pawar ,  Sunil Bhaginath Jadhav ,  Sanjay Kisan Dabhade ,  Vikas Vitthalrao Deshmukh ,  Bharat Dhond ,  Satish Birajdar ,  Mohammad Usman Shaikh ,  Deepak Dekhane ,  Piyush Ambalal Patel

发明人： Sachin Bhagwat ,  Prasad Keshav Deshpande ,  Satish Bhawsar ,  Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Shivaji Sampatrao Pawar ,  Sunil Bhaginath Jadhav ,  Sanjay Kisan Dabhade ,  Vikas Vitthalrao Deshmukh ,  Bharat Dhond ,  Satish Birajdar ,  Mohammad Usman Shaikh ,  Deepak Dekhane ,  Piyush Ambalal Patel

IPC分类号： C07D487/00 ,  A61K31/44 ,  C07D471/08 ,  A61K31/424 ,  A61K31/43 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/546 ,  C07D519/00 ,  C07D498/04

CPC分类号： C07D471/08 ,  A61K31/424 ,  A61K31/43 ,  A61K31/431 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/46 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/546 ,  A61K45/06 ,  C07D498/04 ,  C07D519/00 ,  A61K2300/00

摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

摘要翻译： 公开了式（I）化合物及其制备和用于预防或治疗细菌感染的方法。

公开(公告)号：US20150203503A1

公开(公告)日：2015-07-23

申请号：US14365064

申请日：2013-04-19

申请人： Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Bharat Dond ,  Amol Kale ,  Loganathan Velupillai ,  Deepak Dekhane ,  Satish Shrimant Birajdar ,  Mohammad Usman Shaikh ,  Sushilkumar Maurya ,  Piyush Ambalal Patel ,  Prasad Dixit ,  Mangesh Pawar ,  Mahesh Vithalbhai Patel ,  Sachin Bhagwat

发明人： Vijaykumar Jagdishwar Patil ,  Ravikumar Tadiparthi ,  Bharat Dond ,  Amol Kale ,  Loganathan Velupillai ,  Deepak Dekhane ,  Satish Shrimant Birajdar ,  Mohammad Usman Shaikh ,  Sushilkumar Maurya ,  Piyush Ambalal Patel ,  Prasad Dixit ,  Mangesh Pawar ,  Mahesh Vithalbhai Patel ,  Sachin Bhagwat

IPC分类号： C07D487/08 ,  A61K45/06 ,  A61K31/55 ,  A61K31/496 ,  A61K31/439 ,  A61K31/4545

CPC分类号： C07D471/08 ,  A61K31/407 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/546 ,  A61K31/55 ,  A61K45/06 ,  A61P31/04 ,  C07C211/63 ,  C07D487/08

摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.

摘要翻译： 公开了式（I）化合物及其制备和用于预防或治疗细菌感染的方法。

公开(公告)号：US20140005133A1

公开(公告)日：2014-01-02

申请号：US13991762

申请日：2011-02-03

申请人： Bharat Trivedi ,  Prasad Deshpande ,  Ravikumar Tadiparthi ,  Sunil Gupta ,  Santosh Diwakar ,  Shivaji Pawar ,  Vijay Patil ,  Deepak Dekhane ,  Mahesh Patel ,  Satish Bhavsar ,  Amit Mishra ,  Manish Solanki ,  Mohammad Jafri ,  Sachin Bhagwat

发明人： Bharat Trivedi ,  Prasad Deshpande ,  Ravikumar Tadiparthi ,  Sunil Gupta ,  Santosh Diwakar ,  Shivaji Pawar ,  Vijay Patil ,  Deepak Dekhane ,  Mahesh Patel ,  Satish Bhavsar ,  Amit Mishra ,  Manish Solanki ,  Mohammad Jafri ,  Sachin Bhagwat

IPC分类号： C07H17/08 ,  C07D417/04

CPC分类号： C07H17/08 ,  C07D417/04 ,  C07H23/00

摘要： The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.

摘要翻译： 本发明涉及具有抗微生物活性的式（I）的酮内酯化合物及其药学上可接受的盐，溶剂合物，水合物，多晶型物和立体异构体。 本发明还提供含有本发明化合物的药物组合物和本发明化合物治疗或预防微生物感染的方法，其中T为-C * H（R 1）-P-Q; R1是氢; 未取代或取代的低级烷基，环烷基或芳基; P是杂芳基环; Q是未取代或取代的芳基或杂芳基环; P通过碳 - 碳键连接到Q上; 并且R 3是氢或氟，条件是当R 1是氢时，R 3是氟。

公开(公告)号：US09175031B2

公开(公告)日：2015-11-03

申请号：US13991762

申请日：2011-02-03

申请人： Bharat Trivedi ,  Prasad Deshpande ,  Ravikumar Tadiparthi ,  Sunil Gupta ,  Santosh Diwakar ,  Shivaji Pawar ,  Vijay Patil ,  Deepak Dekhane ,  Mahesh Patel ,  Satish Bhavsar ,  Amit Mishra ,  Manish Solanki ,  Mohammad Jafri ,  Sachin Bhagwat

发明人： Bharat Trivedi ,  Prasad Deshpande ,  Ravikumar Tadiparthi ,  Sunil Gupta ,  Santosh Diwakar ,  Shivaji Pawar ,  Vijay Patil ,  Deepak Dekhane ,  Mahesh Patel ,  Satish Bhavsar ,  Amit Mishra ,  Manish Solanki ,  Mohammad Jafri ,  Sachin Bhagwat

IPC分类号： A61K31/70 ,  C07H17/08 ,  C07H23/00 ,  C07D417/04

CPC分类号： C07H17/08 ,  C07D417/04 ,  C07H23/00

摘要： The invention relates to ketolide compounds of Formula (I) and their pharmaceutically acceptable salts, solvates, hydrates, polymorphs and stereoisomers having antimicrobial activity. The invention also provides pharmaceutical compositions containing the compounds of invention and methods of treating or preventing microbial infections with the compounds of invention, wherein, T is —C*H(R1)—P-Q; R1 is hydrogen; unsubstituted or substituted lower alkyl, cycloalkyl or aryl; P is heteroaryl ring; Q is unsubstituted or substituted aryl or heteroaryl ring; and P is attached to Q via carbon-carbon link; and R3 is hydrogen or fluorine, With the provision that when R1 is hydrogen, R3 is fluorine.

摘要翻译： 本发明涉及具有抗微生物活性的式（I）的酮内酯化合物及其药学上可接受的盐，溶剂合物，水合物，多晶型物和立体异构体。 本发明还提供含有本发明化合物的药物组合物和本发明化合物治疗或预防微生物感染的方法，其中T为-C * H（R 1）-P-Q; R1是氢; 未取代或取代的低级烷基，环烷基或芳基; P是杂芳基环; Q是未取代或取代的芳基或杂芳基环; P通过碳 - 碳键连接到Q上; 并且R 3是氢或氟，条件是当R 1是氢时，R 3是氟。