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    Dual control sustained release drug delivery systems and methods for preparing same
    1.
    发明授权
    Dual control sustained release drug delivery systems and methods for preparing same 失效
    双重控制缓释药物递送系统及其制备方法

    公开(公告)号：US5656296A

    公开(公告)日：1997-08-12

    申请号：US476490

    申请日：1995-06-07

    申请人： Sadath U. Khan ,  Phyllis Ying ,  Russell U. Nesbitt ,  Mahdi B. Fawzi ,  Jay Weiss

    发明人： Sadath U. Khan ,  Phyllis Ying ,  Russell U. Nesbitt ,  Mahdi B. Fawzi ,  Jay Weiss

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  A61K9/24

    CPC分类号： A61K9/2013 ,  A61K9/2846 ,  A61K9/2866

    摘要： The present invention pertains to a dual control sustained release drug delivery system which comprises a core and a porous coating layer over the core, wherein the coated core comprises (A) a core comprising in percentages by weight of the core composition (a) a medicament present in an amount from about 60% to about 90%; (b) an edible material having a melting point from about 25.degree. C. to about 100.degree. C. selected from the group consisting of (i) fatty acids having an iodine value from about 1 to about 10, (ii) natural waxes, (iii) synthetic waxes, and (iv) mixtures thereof, present in an amount from about 5% to about 40%; and (B) a porous coating layer over the core comprising in percentages by weight of the coating layer composition (a) a pH-independent water-insoluble polymer present in an amount from about 40% to about 80%; and (b) a water-soluble film forming polymer present in an amount from about 20% to about 60%.

    摘要翻译： 本发明涉及一种双重控制缓释药物递送系统，其包含核心上的核心和多孔涂层，其中涂覆的核心包含（A）核心组合物（a）的重量百分比的核心，药物 以约60％至约90％的量存在; （b）熔点约25℃至约100℃的可食用材料，其选自（i）碘值约1至约10的脂肪酸，（ii）天然蜡， （iii）合成蜡，和（iv）其混合物，其量为约5％至约40％; 和（B）核心上的多孔涂层，其包含重量百分比的涂层组合物（a），其以约40％至约80％的量存在; pH非依赖性水不溶性聚合物; 和（b）以约20％至约60％的量存在的水溶性成膜聚合物。

    Solid pharmaceutical dispersions
    6.
    发明授权
    Solid pharmaceutical dispersions 失效
    固体药物分散体

    公开(公告)号：US06677362B1

    公开(公告)日：2004-01-13

    申请号：US08218495

    申请日：1994-03-28

    申请人： Isaac Ghebre-Sellassie ,  Robert Reisch, Jr. ,  Riten Parikh ,  Mahdi B. Fawzi ,  Russell U. Nesbitt

    发明人： Isaac Ghebre-Sellassie ,  Robert Reisch, Jr. ,  Riten Parikh ,  Mahdi B. Fawzi ,  Russell U. Nesbitt

    IPC分类号： A61K31425

    CPC分类号： A61K9/146 ,  A61K9/1694

    摘要： A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.

    摘要翻译： 通过将药物与聚合物载体如聚乙烯吡咯烷酮组合来提高改善水溶性差的药物的生物利用度的新型固体药物分散体。 该药物与载体组合，而不需要通过使用部分溶解药物和/或增塑聚合物的过渡化合物例如聚乙二醇来使用有机溶剂或熔融温度（融合）。