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1.发明授权Dual control sustained release drug delivery systems and methods for preparing same 失效双重控制缓释药物递送系统及其制备方法
公开(公告)号：US5656296A
公开(公告)日：1997-08-12
申请号：US476490
申请日：1995-06-07
申请人： Sadath U. Khan , Phyllis Ying , Russell U. Nesbitt , Mahdi B. Fawzi , Jay Weiss
发明人： Sadath U. Khan , Phyllis Ying , Russell U. Nesbitt , Mahdi B. Fawzi , Jay Weiss
CPC分类号： A61K9/2013 , A61K9/2846 , A61K9/2866
摘要： The present invention pertains to a dual control sustained release drug delivery system which comprises a core and a porous coating layer over the core, wherein the coated core comprises (A) a core comprising in percentages by weight of the core composition (a) a medicament present in an amount from about 60% to about 90%; (b) an edible material having a melting point from about 25.degree. C. to about 100.degree. C. selected from the group consisting of (i) fatty acids having an iodine value from about 1 to about 10, (ii) natural waxes, (iii) synthetic waxes, and (iv) mixtures thereof, present in an amount from about 5% to about 40%; and (B) a porous coating layer over the core comprising in percentages by weight of the coating layer composition (a) a pH-independent water-insoluble polymer present in an amount from about 40% to about 80%; and (b) a water-soluble film forming polymer present in an amount from about 20% to about 60%.
摘要翻译： 本发明涉及一种双重控制缓释药物递送系统，其包含核心上的核心和多孔涂层，其中涂覆的核心包含（A）核心组合物（a）的重量百分比的核心，药物 以约60％至约90％的量存在; （b）熔点约25℃至约100℃的可食用材料，其选自（i）碘值约1至约10的脂肪酸，（ii）天然蜡， （iii）合成蜡，和（iv）其混合物，其量为约5％至约40％; 和（B）核心上的多孔涂层，其包含重量百分比的涂层组合物（a），其以约40％至约80％的量存在; pH非依赖性水不溶性聚合物; 和（b）以约20％至约60％的量存在的水溶性成膜聚合物。
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公开(公告)号：US4851545A
公开(公告)日：1989-07-25
申请号：US57467
申请日：1987-06-02
CPC分类号： C08F26/06 , A61K9/284 , A61K9/2846 , A61K9/7023 , A61L15/24 , C07D207/38 , G02B1/043
摘要： A new series of copolymers such as N-isopropyl-3-methylene-2-pyrrolidone and 2-hydroxyethylmethacrylate which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.
摘要翻译： 新的一系列共聚物，如N-异丙基-3-亚甲基-2-吡咯烷酮和甲基丙烯酸2-羟基乙酯，可用作固体剂型的涂层，用于透皮装置，伤口敷料材料和隐形眼镜。 还公开了制备单体和聚合物的方法以及含有这种聚合物的药物组合物。
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公开(公告)号：US4814173A
公开(公告)日：1989-03-21
申请号：US93850
申请日：1987-09-08
CPC分类号： A61K9/7069 , A61K47/34
摘要： A composition for the transmembranal, including transdermal administration of a pharmaceutical preparation comprising medical grade dimethylsiloxane, a catalyst capable of forming an elastomer, a permeation enhancer and a biologically active material, as well as a device for administering the aforementioned compositions and also a method for administering transdermally to a mammal an effective amount of the aforementioned compositions is herein described.
摘要翻译： 用于跨膜的组合物，包括透皮给药包含医用二甲基硅氧烷的药物制剂，能够形成弹性体的催化剂，渗透促进剂和生物活性物质，以及用于给予上述组合物的装置，以及用于 本文描述了向哺乳动物经皮给药有效量的上述组合物。
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公开(公告)号：US4789547A
公开(公告)日：1988-12-06
申请号：US063204
申请日：1987-06-17
CPC分类号： A61K9/7084 , A61K47/32 , A61K47/38 , A61K9/0014
摘要： A composition for the transmembranal, including transdermal, administration of a pharmaceutical preparation comprising cross-linked carboxymethylcellulose, an alcohol soluble poly (2-hydroxyethyl) methacrylate), a permeation enhancer, such as a mixture of linoleic acid and propylene glycol, and a biologically active material, as well as a device for administering the aforementioned composition to mammals, and also a method for administering transdermally to a mammal an effective amount of the aforementioned composition.
摘要翻译： 用于跨膜的组合物，包括经皮，施用包含交联的羧甲基纤维素，醇可溶性聚（2-羟乙基）甲基丙烯酸酯）的药物制剂，渗透促进剂，例如亚油酸和丙二醇的混合物，以及生物学 活性物质，以及用于向哺乳动物施用前述组合物的装置，以及向哺乳动物经皮施用有效量的上述组合物的方法。
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公开(公告)号：US4696812A
公开(公告)日：1987-09-29
申请号：US791836
申请日：1985-10-28
IPC分类号： A61K38/46 , A61K38/48 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/34 , A61L26/00 , A61P7/04 , A61K9/70 , A61K37/48 , A61L15/00
CPC分类号： A61L26/0047 , A61K38/4833 , Y10S128/22
摘要： Thrombin solutions can be rendered storage stable using stabilizing quantities of an anti-autolytic buffer in combination with low levels of saline and glycerol to prevent denaturation.
摘要翻译： 可以使用稳定量的抗自溶解缓冲液与低水平的盐水和甘油结合使凝血酶溶液保持稳定，以防变性。
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公开(公告)号：US4931519A
公开(公告)日：1990-06-05
申请号：US347630
申请日：1989-05-05
CPC分类号： C08F26/06 , A61K9/284 , A61K9/2846 , A61K9/7023 , A61L15/24 , C07D207/38 , G02B1/043
摘要： A new series of copolymers which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.
摘要翻译： 可用作固体剂型涂层，透皮装置，伤口敷料材料和隐形眼镜的新系列共聚物。 还公开了制备单体和聚合物的方法以及含有这种聚合物的药物组合物。
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公开(公告)号：US06677362B1
公开(公告)日：2004-01-13
申请号：US08218495
申请日：1994-03-28
申请人： Isaac Ghebre-Sellassie , Robert Reisch, Jr. , Riten Parikh , Mahdi B. Fawzi , Russell U. Nesbitt
发明人： Isaac Ghebre-Sellassie , Robert Reisch, Jr. , Riten Parikh , Mahdi B. Fawzi , Russell U. Nesbitt
IPC分类号： A61K31425
CPC分类号： A61K9/146 , A61K9/1694
摘要： A novel solid pharmaceutical dispersion that improves the bioavailability of poorly water soluble drugs is produced by combining the drug with a polymer carrier such as polyvinylpyrrolidone. The drug is combined with the carrier without the need for using organic solvents or melting temperatures (fusion) through the use of a transition compound such as polyethylene glycol which partially solubilizes the drug and/or plasticizes the polymer.
摘要翻译： 通过将药物与聚合物载体如聚乙烯吡咯烷酮组合来提高改善水溶性差的药物的生物利用度的新型固体药物分散体。 该药物与载体组合，而不需要通过使用部分溶解药物和/或增塑聚合物的过渡化合物例如聚乙二醇来使用有机溶剂或熔融温度（融合）。
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8.发明授权Methylene pyrrolidone copolymers for contact lens and pharmaceutical preparations 失效用于隐形眼镜和药物制剂的亚甲基吡咯烷酮共聚物
公开(公告)号：US5035884A
公开(公告)日：1991-07-30
申请号：US480431
申请日：1990-02-15
CPC分类号： A61K9/7053 , A61K9/284 , A61K9/2846 , A61K9/7061 , A61L15/24 , C07D207/38 , C08F26/06 , G02B1/043
摘要： A new series of copolymers which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.
摘要翻译： 可用作固体剂型涂层，透皮装置，伤口敷料材料和隐形眼镜的新系列共聚物。 还公开了制备单体和聚合物的方法以及含有这种聚合物的药物组合物。
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9.发明授权Transdermal drug delivery device comprising copolymers of N-morpholinoethyl methacrylate and 2-hydroxylmethacrylate 失效透皮药物递送装置包括甲基丙烯酸N-吗啉代乙酯和2-羟基甲基丙烯酸酯的共聚物
公开(公告)号：US4857313A
公开(公告)日：1989-08-15
申请号：US55095
申请日：1987-05-28
IPC分类号： C08F220/36
CPC分类号： C08F220/36
摘要： The invention concerns a novel copolymer of N-morpholinoethyl methacrylate and 2-hydroxyethyl methacrylate which can be used in transdermal delivery systems or in oral controlled release products. The invention also concerns a process for preparing the copolymer and a method of using it to administer pharmaceutically active substances.
摘要翻译： 本发明涉及甲基丙烯酸N-吗啉代乙酯和甲基丙烯酸2-羟基乙酯的新型共聚物，其可用于透皮递送系统或口服控释产物中。 本发明还涉及一种制备该共聚物的方法及其用于施用药物活性物质的方法。
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公开(公告)号：US5686104A
公开(公告)日：1997-11-11
申请号：US246919
申请日：1994-05-20
申请人： Nancy Mills , Nouman A. Muhammad , Jay Weiss , Russell U. Nesbitt
发明人： Nancy Mills , Nouman A. Muhammad , Jay Weiss , Russell U. Nesbitt
CPC分类号： A61K47/02 , A61K31/40 , A61K9/2009 , Y10S514/824 , Y10S514/97
摘要： An oral pharmaceutical composition is provided for treating hypercholestereolemia or hyperlipidemia containing an advantageous formulation for stabilizing the HMG-CoA coenzyme A inhibitor, CI-981 Hemi-Calcium, of formula (IA) ##STR1## with effective amounts of calcium carbonate. A method for preparing a CI-981 stabilizing composition is described.
摘要翻译： 提供口服药物组合物用于治疗含有有效配方的高胆固醇血症或高脂血症，用于将具有有效量的碳酸钙的HMG-CoA辅酶A抑制剂CI-981 Hemi-Calcium与式（IA）“IMAGE”稳定。 描述了制备CI-981稳定化组合物的方法。
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