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公开(公告)号:US20150094271A1
公开(公告)日:2015-04-02
申请号:US14502088
申请日:2014-09-30
Applicant: Samsung Electronics Co., Ltd.
Inventor: Jung-Hoon Lee , Eunji Kang , Hye Yoon Kang , Dongkyu Shin , Jae Il Lee , Jieun Han , Jung Min Lee
IPC: C07K14/47 , C12N7/00 , C07K14/005
CPC classification number: C12N7/00 , A61K38/00 , C07K14/4746 , C07K2319/10 , C07K2319/73
Abstract: A leucine zipper variant, a polynucleotide encoding the leucine zipper variant, a method of preparing a leucine zipper variant, a method of inhibiting HDM2- and/or HDMX using the leucine zipper variant, and a method of the prevention and/or treatment of cancer using the leucine zipper variant.
Abstract translation: 亮氨酸拉链变体,编码亮氨酸拉链变体的多核苷酸,制备亮氨酸拉链变体的方法,使用亮氨酸拉链变体抑制HDM2-和/或HDMX的方法,以及预防和/或治疗癌症的方法 使用亮氨酸拉链变体。
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公开(公告)号:US20150329847A1
公开(公告)日:2015-11-19
申请号:US14716275
申请日:2015-05-19
Applicant: Samsung Electronics Co., Ltd.
Inventor: Jae Il Lee , Hye Yoon Kang , Dongkyu Shin , Jung Min Kim , Jungmin Lee
CPC classification number: A61K38/03 , A61K38/00 , A61K38/482 , A61K39/3955 , C07K4/00 , C07K16/2863 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/70 , C12N9/6467 , C12Y304/21079
Abstract: A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein.
Abstract translation: 包含粒酶B,细胞穿透肽,切割位点和靶向部分的融合蛋白,包含融合蛋白的细胞膜渗透用组合物和包含该融合蛋白的抗癌组合物。
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公开(公告)号:US09724378B2
公开(公告)日:2017-08-08
申请号:US14716275
申请日:2015-05-19
Applicant: Samsung Electronics Co., Ltd.
Inventor: Jae Il Lee , Hye Yoon Kang , Dongkyu Shin , Jung Min Kim , Jungmin Lee
CPC classification number: A61K38/03 , A61K38/00 , A61K38/482 , A61K39/3955 , C07K4/00 , C07K16/2863 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/50 , C07K2319/70 , C12N9/6467 , C12Y304/21079
Abstract: A fusion protein including granzyme B, a cell penetrating peptide, a cleavage site, and a targeting moiety, a composition for cell membrane penetration comprising the fusion protein, and an anticancer composition comprising the fusion protein.
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公开(公告)号:US09470677B2
公开(公告)日:2016-10-18
申请号:US14554955
申请日:2014-11-26
Applicant: Samsung Electronics Co., Ltd.
Inventor: Jungmin Lee , Jae Il Lee , Soshin Ahn , Hye Yoon Kang
IPC: G01N33/574 , G01N33/50
CPC classification number: G01N33/502 , C12N5/0006 , C12N2501/998 , G01N2333/705 , G01N2500/10
Abstract: A cell having a surface coated with Annexin A1 (ANXA1), a method of detecting a substance binding to ANXA1 using the cell, and a method of preparing the cell are provided.
Abstract translation: 提供了具有被膜蛋白A1(ANXA1)包被的表面的细胞,使用该细胞检测与ANXA1结合的物质的方法以及制备该细胞的方法。
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公开(公告)号:US09365833B2
公开(公告)日:2016-06-14
申请号:US14502088
申请日:2014-09-30
Applicant: Samsung Electronics Co., Ltd.
Inventor: Jung-Hoon Lee , Eunji Kang , Hye Yoon Kang , Dongkyu Shin , Jae Il Lee , Jieun Han , Jung Min Lee
CPC classification number: C12N7/00 , A61K38/00 , C07K14/4746 , C07K2319/10 , C07K2319/73
Abstract: A leucine zipper variant, a polynucleotide encoding the leucine zipper variant, a method of preparing a leucine zipper variant, a method of inhibiting HDM2- and/or HDMX using the leucine zipper variant, and a method of the prevention and/or treatment of cancer using the leucine zipper variant.
Abstract translation: 亮氨酸拉链变体,编码亮氨酸拉链变体的多核苷酸,制备亮氨酸拉链变体的方法,使用亮氨酸拉链变体抑制HDM2-和/或HDMX的方法,以及预防和/或治疗癌症的方法 使用亮氨酸拉链变体。
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