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10 条记录 (耗时 0.051 秒)

    Security substrate for documents of value
    4.
    发明授权
    Security substrate for documents of value 失效
    安全基板的价值文件

    公开(公告)号：US06686027B1

    公开(公告)日：2004-02-03

    申请号：US09669425

    申请日：2000-09-25

    申请人： Omar Caporaletti ,  John Nicholas Disano ,  Jack Scott

    发明人： Omar Caporaletti ,  John Nicholas Disano ,  Jack Scott

    IPC分类号： B32B2302

    CPC分类号： B32B7/02 ,  B42D25/29 ,  Y10T428/24802 ,  Y10T428/31678 ,  Y10T428/31823 ,  Y10T428/31909

    摘要： A security substrate for a document of value comprises a laminate including a generally transparent core layer and generally transparent outer layers on opposite sides of the core layer. At least one interference filter is embedded within the laminate. The interference filter includes a highly reflective opaque layer on a surface of the core layer and an optically variable thin film multilayer overlying at least a portion of the opaque layer. The interference filter is covered by one of the outer layers.

    摘要翻译： 用于文件证件的安全基板包括层叠体，其包括通常透明的芯层和在芯层的相对侧上的通常透明的外层。 至少一个干涉滤光片嵌入层压板内。 干涉滤光器包括在芯层的表面上的高反射不透明层和覆盖在不透明层的至少一部分上的光学可变薄膜多层。 干涉滤光片被外层之一覆盖。

    PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS
    7.
    发明申请
    PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS 审中-公开
    哌啶衍生物作为CCR5拮抗剂有用

    公开(公告)号：US20080095740A1

    公开(公告)日：2008-04-24

    申请号：US11925119

    申请日：2007-10-26

    申请人： Michael Miller ,  Jack Scott

    发明人： Michael Miller ,  Jack Scott

    IPC分类号： A61K31/506 ,  A61K31/538 ,  A61K31/551 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/708 ,  A61K38/20 ,  A61P31/18

    CPC分类号： C07D401/14

    摘要： The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

    摘要翻译： 本发明提供下式的化合物或其药学上可接受的盐或溶剂合物，其中各种部分如说明书中所定义。 本发明还提供含有本发明化合物的药物组合物和使用本发明化合物的治疗方法。 本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。 本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣 ，哮喘，过敏或多发性硬化。

    Bipiperidinyl derivatives useful as inhibitors of chemokine receptors
    8.
    发明申请
    Bipiperidinyl derivatives useful as inhibitors of chemokine receptors 失效
    可用作趋化因子受体抑制剂的二哌啶基衍生物

    公开(公告)号：US20060025441A1

    公开(公告)日：2006-02-02

    申请号：US10979075

    申请日：2004-11-01

    申请人： Michael Miller ,  Jack Scott

    发明人： Michael Miller ,  Jack Scott

    IPC分类号： A61K31/4545 ,  C07D401/04

    CPC分类号： C07D413/14 ,  C07D401/14

    摘要： In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

    摘要翻译： 在其许多实施方案中，本发明提供了作为CCR5受体的抑制剂的新类型的联哌啶化合物，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种这样的化合物的药物制剂的方法，以及 使用这些化合物或药物组合物治疗，预防，抑制或改善与CCR5相关的一种或多种疾病的方法。 本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。 本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣 ，哮喘，过敏或多发性硬化。