公开(公告)号：US20120282631A1

公开(公告)日：2012-11-08

申请号：US13469316

申请日：2012-05-11

申请人： Samuel Chun Lap LO ,  Yoki Kwok Chu BUTT ,  Wallace Woon Fong LEUNG

发明人： Samuel Chun Lap LO ,  Yoki Kwok Chu BUTT ,  Wallace Woon Fong LEUNG

IPC分类号： G01N33/574 ,  C12Q1/26 ,  G01N27/26 ,  C12Q1/48 ,  G01N27/62 ,  G01N33/573

CPC分类号： G01N33/57423 ,  G01N2333/4718 ,  G01N2333/908 ,  G01N2333/912 ,  G01N2333/95 ,  G01N2800/52

摘要： A method of identifying and classifying non-small-cell lung carcinoma in a biological sample includes a first test wherein the expression level of at least one biomarker is measured in a sample, the at least one=biomarker is selected from a first group consisting of chaperonin, 2,3-bisphosphoglycerate mutase, thymidine phosphorylase, and minichromosome maintenance deficient protein 5, and comparing the measured expression levels against a normal expression level, wherein a significant difference diagnoses or aids in the diagnosis of non-small cell lung carcinoma; and a second test wherein the expression level of at least one biomarker is measured in the sample, the at least one biomarker is selected from a second group consisting of selenium binding protein and Napsin A, and comparing the measured expression level against a normal expression level, wherein a significant difference confirms or aids in confirmation of Non-Small Cell Carcinoma.

摘要翻译： 在生物样品中鉴定和分类非小细胞肺癌的方法包括第一试验，其中在样品中测量至少一种生物标志物的表达水平，所述至少一种=生物标志物选自由 伴侣蛋白，2,3-二磷酸甘油酸变位酶，胸苷磷酸化酶和微染色体维持缺陷蛋白5，并比较测量的表达水平与正常表达水平，其中显着差异诊断或辅助诊断非小细胞肺癌; 以及第二测试，其中在样品中测量至少一种生物标记的表达水平，所述至少一种生物标志物选自由硒结合蛋白和Napsin A组成的第二组，并将测量的表达水平与正常表达水平进行比较 ，其中显着差异证实或有助于确认非小细胞癌。