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公开(公告)号：US08709732B2
公开(公告)日：2014-04-29
申请号：US13025183
申请日：2011-02-11
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： G01N27/62 , G01N33/57446
摘要： A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression of one or more protein biomarks in the group consisting albumin, T-kininogen I, α-2-HS glycoprotein, α-1-antitrypsin, afamin and γ-actin and/or detection of under-expression of one or more protein biomarks in the group consisting stress 70 protein, apolipoprotein A-I, apolipoprotein A-IV, transthyretin and murinoglobulin is indicative of the presence of gastric cancer.
摘要翻译： 一组指示早期胃癌的生物标志物和通过将这些生物标志物引导到血液样品中来在早期诊断胃癌的方法。 检测由白蛋白，T激肽原I，α-2-HS糖蛋白，α-1-抗胰蛋白酶，微生物和γ-肌动蛋白组成的组中的一种或多种蛋白质生物标志物的过表达和/或一种低表达的检测 或更多的蛋白质生物标记物，其中包括应激70蛋白，载脂蛋白AI，载脂蛋白A-IV，转甲状腺素蛋白和小球蛋白是胃癌存在的指示。
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2.发明申请公开(公告)号：US20110245580A1
公开(公告)日：2011-10-06
申请号：US13164293
申请日：2011-06-20
IPC分类号： A61M37/00
CPC分类号： A61B5/4839 , A61B5/01 , A61B5/14539 , A61B5/4266 , A61B5/441 , A61B5/4878
摘要： Current methods of delivering drug usually require a certain degree of human intervention. For example, a doctor, a paramedic or a patient is required to inject insulin manually when the blood sugar level becomes low. This invention provides a medical device for use with a patient for performing at least one of the functions of delivering drug and performing physical therapy to the patient. The device of this invention includes a sensor for measuring at least one parameter from the patient, an analyzer for analyzing the parameter to determine appropriate function to be carried out on the patient by said medical device, and at least one actuator to perform at least one of the functions of delivering drug and performing physical therapy.
摘要翻译： 目前传递药物的方法通常需要一定程度的人为干预。 例如，当血糖水平变低时，医生，护理人员或患者需要手动注射胰岛素。 本发明提供了一种用于与病人一起使用的医疗装置，用于执行递送药物和对患者进行物理治疗的功能中的至少一个。 本发明的装置包括用于测量来自患者的至少一个参数的传感器，用于分析参数以确定由所述医疗装置对患者进行的适当功能的分析器，以及执行至少一个执行器 提供药物和进行物理治疗的功能。
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公开(公告)号：US07927788B2
公开(公告)日：2011-04-19
申请号：US11812201
申请日：2007-06-15
CPC分类号： C12Q1/6895 , C07K14/405 , C12Q2600/142 , C12Q2600/158 , G01N33/56961
摘要： The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers.
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4.发明授权公开(公告)号：US08855759B2
公开(公告)日：2014-10-07
申请号：US11907010
申请日：2007-10-09
CPC分类号： A61N1/0456 , A61N1/325 , A61N1/36014 , A61N1/36021
摘要： The present invention relates to a method of treating rheumatic disorders, and symptoms of arthritis specifically. The method involves utilizing transcutaneous electrical nerve stimulation (TENS) in combination with administration of a ginsenoside, such as Rb1.
摘要翻译： 本发明涉及一种特别治疗风湿病和关节炎症状的方法。 该方法包括利用经皮电神经刺激（TENS）与人参皂苷Rb1的施用相结合。
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公开(公告)号：US20130071857A1
公开(公告)日：2013-03-21
申请号：US13025183
申请日：2011-02-11
IPC分类号： G01N27/62 , G01N33/574
CPC分类号： G01N27/62 , G01N33/57446
摘要： A set of biomarkers indicative of early gastric cancer and method of diagnosing gastric cancer at an early stage by directing the these biomarkers in a blood sample. Detection of over-expression of one or more protein biomarks in the group consisting albumin, T-kininogen I, α-2-HS glycoprotein, α-1-antitrypsin, afamin and γ-actin and/or detection of under-expression of one or more protein biomarks in the group consisting stress 70 protein, apolipoprotein A-I, apolipoprotein A-IV, transthyretin and murinoglobulin is indicative of the presence of gastric cancer.
摘要翻译： 一组指示早期胃癌的生物标志物和通过将这些生物标志物引导到血液样品中来在早期诊断胃癌的方法。 检测由白蛋白，T激肽原I，α-2-HS糖蛋白，α-1-抗胰蛋白酶，微生物和γ-肌动蛋白组成的组中的一种或多种蛋白质生物标志物的过表达和/或一种低表达的检测 或更多的蛋白质生物标记物，其中包括应激70蛋白，载脂蛋白AI，载脂蛋白A-IV，转甲状腺素蛋白和小球蛋白是胃癌存在的指示。
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公开(公告)号：US20090220947A1
公开(公告)日：2009-09-03
申请号：US11812101
申请日：2007-06-15
CPC分类号： C12Q1/6895 , C07K14/405 , C12Q2600/142 , C12Q2600/158 , G01N33/56961
摘要： The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers.
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公开(公告)号：US07425412B2
公开(公告)日：2008-09-16
申请号：US11494150
申请日：2006-07-26
CPC分类号： C12Q1/6895 , C07K14/405 , C12Q2600/142 , C12Q2600/158 , G01N33/56961
摘要： The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers.
摘要翻译： 本发明针对识别藻类特征的生物标志物。 本发明进一步针对用于鉴定藻类物种和藻类物种的生物标志物以及检测藻类毒素的存在。 另外的实施方案特征使用可用作生物标志物的藻类生物标志物和多肽的方法。
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8.发明申请METHOD FOR DIAGNOSIS NON-SMALL-CELL-LUNG-CARCINOMA (NSCLC) AND CLASSIFICATION OF ITS SUBTYPES WITH DIFFERENT COMBINATIONS OF 6 PROTEIN BIOMARKERS 审中-公开用于诊断非小细胞肺癌（NSCLC）的方法及其具有6种蛋白质生物标志物不同组合的亚型的分类公开(公告)号：US20120282631A1
公开(公告)日：2012-11-08
申请号：US13469316
申请日：2012-05-11
IPC分类号： G01N33/574 , C12Q1/26 , G01N27/26 , C12Q1/48 , G01N27/62 , G01N33/573
CPC分类号： G01N33/57423 , G01N2333/4718 , G01N2333/908 , G01N2333/912 , G01N2333/95 , G01N2800/52
摘要： A method of identifying and classifying non-small-cell lung carcinoma in a biological sample includes a first test wherein the expression level of at least one biomarker is measured in a sample, the at least one=biomarker is selected from a first group consisting of chaperonin, 2,3-bisphosphoglycerate mutase, thymidine phosphorylase, and minichromosome maintenance deficient protein 5, and comparing the measured expression levels against a normal expression level, wherein a significant difference diagnoses or aids in the diagnosis of non-small cell lung carcinoma; and a second test wherein the expression level of at least one biomarker is measured in the sample, the at least one biomarker is selected from a second group consisting of selenium binding protein and Napsin A, and comparing the measured expression level against a normal expression level, wherein a significant difference confirms or aids in confirmation of Non-Small Cell Carcinoma.
摘要翻译： 在生物样品中鉴定和分类非小细胞肺癌的方法包括第一试验，其中在样品中测量至少一种生物标志物的表达水平，所述至少一种=生物标志物选自由 伴侣蛋白，2,3-二磷酸甘油酸变位酶，胸苷磷酸化酶和微染色体维持缺陷蛋白5，并比较测量的表达水平与正常表达水平，其中显着差异诊断或辅助诊断非小细胞肺癌; 以及第二测试，其中在样品中测量至少一种生物标记的表达水平，所述至少一种生物标志物选自由硒结合蛋白和Napsin A组成的第二组，并将测量的表达水平与正常表达水平进行比较 ，其中显着差异证实或有助于确认非小细胞癌。
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公开(公告)号：US07993823B2
公开(公告)日：2011-08-09
申请号：US11812101
申请日：2007-06-15
CPC分类号： C12Q1/6895 , C07K14/405 , C12Q2600/142 , C12Q2600/158 , G01N33/56961
摘要： The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers.
摘要翻译： 本发明针对识别藻类特征的生物标志物。 本发明进一步针对用于鉴定藻类物种和藻类物种的生物标志物以及检测藻类毒素的存在。 另外的实施方案特征使用可用作生物标志物的藻类生物标志物和多肽的方法。
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公开(公告)号：US20090099349A1
公开(公告)日：2009-04-16
申请号：US12273997
申请日：2008-11-19
IPC分类号： C12N15/11
CPC分类号： C12Q1/6895 , C07K14/405 , C12Q2600/142 , C12Q2600/158 , G01N33/56961
摘要： The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can serve as biomarkers.
摘要翻译： 本发明针对识别藻类特征的生物标志物。 本发明进一步针对用于鉴定藻类物种和藻类物种的生物标志物以及检测藻类毒素的存在。 另外的实施方案特征使用可用作生物标志物的藻类生物标志物和多肽的方法。
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