公开(公告)号：US20160296149A1

公开(公告)日：2016-10-13

申请号：US15078870

申请日：2016-03-23

Applicant: Sandia Corporation ,  STC.UNM

Inventor： Ronen Polsky ,  Philip Rocco Miller ,  Justin T. Baca

IPC: A61B5/145 ,  A61B5/1477 ,  A61B5/1455

CPC classification number: A61B5/14514 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/165 ,  A61B2010/008 ,  A61M2037/0061

Abstract: A transdermal and/or intradermal diagnostic device comprising a combined hollow microneedle interstitial fluid (IF) extraction device and a detector can monitor biomarkers in-situ. For example, electrode transducers with optimally arrayed and designed microneedles can be combined with a suitable pumping method to determine biomarker levels in human subjects under intense physical exertion to monitor metabolic stress and fatigue. The device can perform real-time, in-situ measurements of lactate in human subjects. Monitoring of other biomarkers is straightforward.

Abstract translation: 包括组合的中空微针间质液（IF）提取装置和检测器的透皮和/或皮内诊断装置可以原位监测生物标志物。 例如，具有最佳排列和设计的微针的电极传感器可以与合适的泵送方法结合，以确定强烈体力劳动下人体受试者的生物标志物水平，以监测代谢应激和疲劳。 该装置可以对人类受试者的乳酸进行实时，原位测量。 监测其他生物标志物是直接的。

公开(公告)号：US20210162126A1

公开(公告)日：2021-06-03

申请号：US16954152

申请日：2018-10-11

Applicant: Daniel BARKHUFF ,  Justin T. BACA ,  Peter ZINK ,  Brandon WARRICK ,  STC.UNM

Inventor： Daniel Barkhuff ,  Justin T. Baca ,  Peter Zinc ,  Brandon Warrick

IPC: A61M5/172 ,  A61M5/142 ,  A61M5/20 ,  A61M5/315

Abstract: An auto-injection system is having an injector, one or more sensors, and a controller, the controller activates the injector when the sensors detect a predetermined condition.

公开(公告)号：US20180256086A1

公开(公告)日：2018-09-13

申请号：US15913629

申请日：2018-03-06

Applicant: National Technology & Engineering Solutions of Sandia, LLC ,  STC.UNM

Inventor： Ronen Polsky ,  Philip R. Miller ,  Justin T. Baca

IPC: A61B5/145 ,  A61B5/15

CPC classification number: A61B5/14514 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150312 ,  A61B5/150396 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150984 ,  A61B5/15142

Abstract: A microneedle device comprising a hollow microneedle protruding from the rim of an outer open holder can be used for the extraction of interstitial fluid (ISF). Dermal ISF can be extracted with the microneedle device with minimal pain and no blistering for human subjects. Extracted ISF volumes are sufficient for determining transcriptome and proteome signatures. Similar profiles in ISF, serum, and plasma samples, suggest that ISF can be a proxy for direct blood sampling. This minimally-invasive microneedle device enables real-time health monitoring applications using extracted ISF.