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公开(公告)号：US08980948B2
公开(公告)日：2015-03-17
申请号：US13543289
申请日：2012-07-06
IPC分类号： A61K31/5575 , A61K8/69 , A61Q7/00
CPC分类号： A61K8/69 , A61K31/5575 , A61Q7/00
摘要： Travoprost medicament compositions for non-daily topical application are useful for simulating or inducing the growth and/or decreasing the loss and/or increasing the density and/or reducing the heterogeneity in the diameter of human hair shafts/follicles, e.g., for the treatment of androgenic alopecia, such medicament compositions being at least twice applied over a time interval of greater than 24 hours.
摘要翻译： 用于非日常局部应用的曲伏前列素药物组合物可用于模拟或诱导人发丝/毛囊直径的生长和/或减少损失和/或增加密度和/或减少异质性，例如用于治疗 的雄激素性脱发，所述药物组合物在大于24小时的时间间隔内至少施用两次。
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公开(公告)号：US20100190853A1
公开(公告)日：2010-07-29
申请号：US12710382
申请日：2010-02-23
IPC分类号： A61K31/216 , A61P17/14
CPC分类号： A61K8/69 , A61K31/5575 , A61Q7/00
摘要： Travoprost medicament compositions for non-daily topical application are useful for simulating or inducing the growth and/or decreasing the loss and/or increasing the density and/or reducing the heterogeneity in the diameter of human hair shafts/follicles, e.g., for the treatment of androgenic alopecia, such medicament compositions being at least twice applied over a time interval of greater than 24 hours.
摘要翻译： 用于非日常局部应用的曲伏前列素药物组合物可用于模拟或诱导人发丝/毛囊直径的生长和/或减少损失和/或增加密度和/或减少异质性，例如用于治疗 的雄激素性脱发，所述药物组合物在大于24小时的时间间隔内至少施用两次。
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公开(公告)号：US08227514B2
公开(公告)日：2012-07-24
申请号：US12710382
申请日：2010-02-23
IPC分类号： A61K31/5575
CPC分类号： A61K8/69 , A61K31/5575 , A61Q7/00
摘要： Travoprost medicament compositions for non-daily topical application are useful for simulating or inducing the growth and/or decreasing the loss and/or increasing the density and/or reducing the heterogeneity in the diameter of human hair shafts/follicles, e.g., for the treatment of androgenic alopecia, such medicament compositions being at least twice applied over a time interval of greater than 24 hours.
摘要翻译： 用于非日常局部应用的曲伏前列素药物组合物可用于模拟或诱导人发丝/毛囊直径的生长和/或减少损失和/或增加密度和/或减少异质性，例如用于治疗 的雄激素性脱发，所述药物组合物在大于24小时的时间间隔内至少施用两次。
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公开(公告)号：US20110275075A1
公开(公告)日：2011-11-10
申请号：US13120116
申请日：2009-09-21
申请人： Sandrine Rethore
发明人： Sandrine Rethore
IPC分类号： C12Q1/68 , G01N33/53 , C07D401/04 , C12Q1/02
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of alopecia is described. The method can include determining the capacity of a compound to modulate the expression or the activity of a SOX transcription factor. The use of modulators of the expression or the activity of the transcription factor for the treatment of alopecia is also described. Methods for the in vitro diagnosis or prognosis of the pathology are also described herein.
摘要翻译： 描述了用于筛选用于预防或治疗性脱发的候选化合物的体外方法。 该方法可以包括确定化合物调节SOX转录因子的表达或活性的能力。 还描述了用于治疗脱发的转录因子的表达或活性的调节剂的用途。 本文还描述了用于体外诊断或预后的病理学方法。
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公开(公告)号：US09120753B2
公开(公告)日：2015-09-01
申请号：US13519113
申请日：2010-12-22
申请人： Cédric Poinsard , Patrice Lucien Maurice Collette , Isabelle Marie Joëlle Martine Collette , Pascale Mauvais , Jean-Michel Linget , Sandrine Rethore
IPC分类号： C07D213/74 , C07D213/85 , A61K8/49 , A61K31/44 , A61Q19/00 , A61Q7/02
CPC分类号： C07D213/85 , A61K8/4906 , A61K8/4926 , A61K31/44 , A61Q7/02 , A61Q19/00 , A61Q19/008 , C07D213/74
摘要： The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): or one of its pharmaceutically acceptable salts, solvates or hydrates in the preparation of a medicament to treat skin pathologies is described.
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公开(公告)号：US20130178633A1
公开(公告)日：2013-07-11
申请号：US13519120
申请日：2010-12-22
申请人： Cédric Poinsard , Pascale Mauvais , Jean-Michel Linget , Sandrine Rethore , Patrice Lucien Maurice Collette , Isabelle Marie Joëlle Martine Collette
IPC分类号： C07D213/74
CPC分类号： C07D213/74
摘要： The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): or one of its pharmaceutically acceptable salts, solvates or hydrates in the preparation of a medicament to treat skin pathologies is described.
摘要翻译： 描述了化合物在治疗皮肤病中的用途。 具体地，描述了式（I）化合物或其药学上可接受的盐，溶剂合物或水合物之一在制备治疗皮肤病理学的药物中的用途。
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公开(公告)号：US20110236893A1
公开(公告)日：2011-09-29
申请号：US13120104
申请日：2009-09-21
申请人： Sandrine Rethore
发明人： Sandrine Rethore
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： An in vitro method of screening for candidate compounds for the preventive or curative treatment of alopecia, which comprises determining the ability of a compound to modulate the expression or the activity of the LGR5 receptor is described. The use of modulators of the expression or of the activity of this receptor for treating alopecia is also described. In addition, methods for the diagnosis or prognosis, in vitro, of this disease are described.
摘要翻译： 描述了筛选用于预防或治疗性脱发的候选化合物的体外方法，其包括测定化合物调节LGR5受体的表达或活性的能力。 还描述了使用该受体的表达或活性的调节剂治疗脱发。 此外，描述了用于诊断或预后这种疾病的方法。
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公开(公告)号：US09050266B2
公开(公告)日：2015-06-09
申请号：US13519100
申请日：2010-12-22
申请人： Cédric Poinsard , Jean-Michel Linget , Sandrine Rethore , Pascale Mauvais , Patrice Lucien Maurice Collette , Isabelle Marie Joëlle Martine Collette
IPC分类号： A61K8/49 , A61K8/69 , A61Q19/00 , A61Q7/00 , A61Q7/02 , A61K31/44 , A61K31/4965 , A61K31/499 , A61K31/505 , C07D213/74 , C07D239/42 , C07D241/20
CPC分类号： C07D239/42 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/69 , A61K31/44 , A61K31/4965 , A61K31/499 , A61K31/505 , A61Q7/00 , A61Q7/02 , A61Q19/00 , A61Q19/008 , C07D213/74 , C07D213/84 , C07D237/20 , C07D237/22 , C07D241/20
摘要： The use of compounds in the treatment of skin disorders is described. In particular, use of a compound of formula (I): or one of its pharmaceutically acceptable salts, solvates or hydrates in the preparation of a medicament to treat skin pathologies is described.
摘要翻译： 描述了化合物在治疗皮肤病中的用途。 具体地，描述了式（I）化合物或其药学上可接受的盐，溶剂合物或水合物之一在制备治疗皮肤病理学的药物中的用途。
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