公开(公告)号：US20050244856A1

公开(公告)日：2005-11-03

申请号：US11058976

申请日：2005-02-16

申请人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

发明人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

IPC分类号： G01N33/53 ,  C07K14/535 ,  C07K16/00 ,  C07K16/24 ,  C12M1/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  G01N37/00 ,  C07H21/04 ,  G01N33/574

CPC分类号： C07K16/243 ,  C12Q1/6886 ,  C12Q2600/156

摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

公开(公告)号：US20050170416A1

公开(公告)日：2005-08-04

申请号：US11059192

申请日：2005-02-16

申请人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

发明人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

IPC分类号： G01N33/53 ,  C07K14/535 ,  C07K16/00 ,  C07K16/24 ,  C12M1/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  G01N37/00 ,  C07H21/04 ,  G01N33/574

CPC分类号： C07K16/243 ,  C12Q1/6886 ,  C12Q2600/156

摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

公开(公告)号：US20050266430A1

公开(公告)日：2005-12-01

申请号：US11059222

申请日：2005-02-16

申请人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

发明人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

IPC分类号： G01N33/53 ,  C07K14/535 ,  C07K16/00 ,  C07K16/24 ,  C12M1/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  G01N37/00 ,  C07H21/04 ,  C12P21/06 ,  G01N33/574

CPC分类号： C07K16/243 ,  C12Q1/6886 ,  C12Q2600/156

摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

公开(公告)号：US20050170417A1

公开(公告)日：2005-08-04

申请号：US11059268

申请日：2005-02-16

申请人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

发明人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

IPC分类号： G01N33/53 ,  C07K14/535 ,  C07K16/00 ,  C07K16/24 ,  C12M1/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  G01N37/00 ,  C07H21/04 ,  G01N33/574

CPC分类号： C07K16/243 ,  C12Q1/6886 ,  C12Q2600/156

摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

公开(公告)号：US20050158810A1

公开(公告)日：2005-07-21

申请号：US11059127

申请日：2005-02-16

申请人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

发明人： Sang Lee ,  Nae Yoo ,  So Yoo ,  Hyun Chung ,  Ki Keum ,  Won Yoo ,  Ki Jeong

IPC分类号： G01N33/53 ,  C07K14/535 ,  C07K16/00 ,  C07K16/24 ,  C12M1/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/566 ,  G01N37/00 ,  G01N33/574 ,  C07H21/04

CPC分类号： C07K16/243 ,  C12Q1/6886 ,  C12Q2600/156

摘要： Disclosed are a method, a composition, a microarray, an antibody and a kit for diagnosis and prognosis of cancer, based on detection of deletion of the exon 3 region of G-CSF gene or levels of a mutated G-CSF protein having a deletion of an amino acid sequence corresponding to the exon 3 region, wherein the deletion of the exon 3 region of the G-CSF gene is used as a cancer biomarker.

摘要翻译： 公开了基于检测到G-CSF基因的外显子3区的缺失或具有缺失的突变的G-CSF蛋白的水平的方法，组合物，微阵列，抗体和用于癌症诊断和预后的试剂盒 的对应于外显子3区域的氨基酸序列，其中G-CSF基因的外显子3区域的缺失被用作癌症生物标志物。

公开(公告)号：US20070065817A1

公开(公告)日：2007-03-22

申请号：US10514072

申请日：2003-05-09

申请人： Sang-Yup Lee ,  Seung Yoo ,  Kyung Chang ,  So Yoo ,  Nae Yo ,  Won Yoo ,  Ki Keum ,  June Kim ,  Gene Lee

发明人： Sang-Yup Lee ,  Seung Yoo ,  Kyung Chang ,  So Yoo ,  Nae Yo ,  Won Yoo ,  Ki Keum ,  June Kim ,  Gene Lee

IPC分类号： C12Q1/68 ,  C12M3/00 ,  C12M1/34 ,  C07H21/04

CPC分类号： C12Q1/689 ,  C12Q2600/16

摘要： The present invention relates to nucleic acid probes which are derived from rRNA genes of non-virus organisms and are useful for the detection of said non-virus infectious organisms in a biological sample. In addition, the present invention relates to compositions and chips useful for the diagnosis of one or more types of infectious diseases comprising said nucleic acid probes.

摘要翻译： 本发明涉及衍生自非病毒生物体的rRNA基因的核酸探针，并且可用于检测生物样品中的所述非病毒感染性生物体。 此外，本发明涉及可用于诊断包含所述核酸探针的一种或多种感染性疾病的组合物和碎片。

公开(公告)号：US20050034194A1

公开(公告)日：2005-02-10

申请号：US10780703

申请日：2004-02-19

申请人： Jong Lee ,  Yun Kim ,  Eun Choi ,  So Yoo ,  Ji Ahn ,  Yang Choi

发明人： Jong Lee ,  Yun Kim ,  Eun Choi ,  So Yoo ,  Ji Ahn ,  Yang Choi

IPC分类号： A01H5/00 ,  C07K14/415 ,  C12N5/10 ,  C12N15/29 ,  C12N15/82

CPC分类号： C12N15/827 ,  C07K14/415

摘要： The present invention relates to a gene controlling the flowering time of plants, and a method for manipulating the flowering time of plants using the gene. More particularly, the present invention relates to a LOV1 gene controlling the flowering time of plants, which is isolated from Arabidopsis thaliana, and also to a method for either delaying the flowering time of plants by overexpressing the LOV1 gene in the plants, or inducing the early flowering of the plants by repressing the expression of the LOV1 gene in the plants.

摘要翻译： 本发明涉及控制植物开花时间的基因，以及使用该基因操作植物开花时间的方法。 更具体地，本发明涉及控制从拟南芥分离的植物的开花时间的LOV1基因，还涉及通过在植物中过表达LOV1基因延迟植物的开花时间的方法，或诱导 通过抑制植物中LOV1基因的表达来早期开花植物。