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公开(公告)号:US08383091B2
公开(公告)日:2013-02-26
申请号:US12879948
申请日:2010-09-10
申请人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
发明人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
CPC分类号: C08L59/00 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/0008 , A61K48/0041 , C12N15/87
摘要: Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.
摘要翻译: 包含聚阳离子,聚阴离子和多核苷酸的可降解络合物可用于体内多核苷酸递送应用。
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公开(公告)号:US07794696B2
公开(公告)日:2010-09-14
申请号:US10946383
申请日:2004-09-21
申请人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
发明人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
IPC分类号: A61K31/74
CPC分类号: C08L59/00 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/0008 , A61K48/0041 , C12N15/87
摘要: Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.
摘要翻译: 包含聚阳离子,聚阴离子和多核苷酸的可降解络合物可用于体内多核苷酸递送应用。
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公开(公告)号:US20110015344A1
公开(公告)日:2011-01-20
申请号:US12879948
申请日:2010-09-10
申请人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
发明人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
CPC分类号: C08L59/00 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/0008 , A61K48/0041 , C12N15/87
摘要: Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.
摘要翻译: 包含聚阳离子,聚阴离子和多核苷酸的可降解络合物可用于体内多核苷酸递送应用。
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公开(公告)号:US20050080033A1
公开(公告)日:2005-04-14
申请号:US10946383
申请日:2004-09-21
申请人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
发明人: Sang Van , Jiadong Zhou , Xiaoli Fu , Lei Yu
CPC分类号: C08L59/00 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/0008 , A61K48/0041 , C12N15/87
摘要: Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.
摘要翻译: 包含聚阳离子,聚阴离子和多核苷酸的可降解络合物可用于体内多核苷酸递送应用。
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公开(公告)号:US20080181852A1
公开(公告)日:2008-07-31
申请号:US12019612
申请日:2008-01-24
IPC分类号: A61K31/337 , A61K47/30 , A61K31/435 , A61K31/70 , A61K49/12 , A61P35/00
CPC分类号: A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译: 制备包含通式(I)和(II)的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这样的聚合物可用于各种药物,靶向,稳定和/或成像剂递送应用。
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公开(公告)号:US20120189554A1
公开(公告)日:2012-07-26
申请号:US13437557
申请日:2012-04-02
CPC分类号: A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译: 制备包含通式(I)和(II)的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这样的聚合物可用于各种药物,靶向,稳定和/或成像剂递送应用。
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公开(公告)号:US20070128118A1
公开(公告)日:2007-06-07
申请号:US11566141
申请日:2006-12-01
申请人: Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
发明人: Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
IPC分类号: A61K49/10 , A61K49/00 , A61K31/785
CPC分类号: A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译: 制备包含通式(I)和(II)的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这些聚合物可用于各种药物,生物分子和成像剂递送应用。
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8.Compositions that include a hydrophobic compound and a polyamino acid conjugate 有权
标题翻译: 包含疏水化合物和聚氨基酸缀合物的组合物公开(公告)号:US08197828B2
公开(公告)日:2012-06-12
申请号:US12117601
申请日:2008-05-08
申请人: Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
发明人: Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
IPC分类号: A61K9/00
CPC分类号: B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译: 制备包括疏水化合物和聚氨基酸缀合物的各种组合物。 本文描述的组合物可用于各种药物,生物分子和成像剂递送应用。
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公开(公告)号:US20090226393A1
公开(公告)日:2009-09-10
申请号:US12397545
申请日:2009-03-04
申请人: Xinghe Wang , Gang Zhao , Sang Van , Lei Yu
发明人: Xinghe Wang , Gang Zhao , Sang Van , Lei Yu
IPC分类号: A61K47/48 , A61P35/00 , A61K31/337 , A61K31/74
CPC分类号: A61K47/645
摘要: Pharmaceutical compositions comprising a PGGA-PTX conjugate are prepared. The pharmaceutical compositions are used to treat a variety of cancers, such as lung cancer, skin cancer, kidney cancer, liver cancer and spleen cancer.
摘要翻译: 制备包含PGGA-PTX缀合物的药物组合物。 药物组合物用于治疗各种癌症,例如肺癌,皮肤癌,肾癌,肝癌和脾癌。
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10.COMPOSITIONS THAT INCLUDE A HYDROPHOBIC COMPOUND AND A POLYAMINO ACID CONJUGATE 有权
标题翻译: 包含疏水化合物和聚氨基酸共混物的组合物公开(公告)号:US20080279777A1
公开(公告)日:2008-11-13
申请号:US12117601
申请日:2008-05-08
申请人: Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
发明人: Sang Van , Yucheng Song , Xinghe Wang , Zheng Hou , Zhongling Feng , Gang Zhao , Lei Yu
CPC分类号: B82Y5/00 , A61K47/645 , A61K47/6925 , A61K49/0056 , A61K49/085 , A61K49/146 , A61K49/1824
摘要: Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.
摘要翻译: 制备包括疏水化合物和聚氨基酸缀合物的各种组合物。 本文描述的组合物可用于各种药物,生物分子和成像剂递送应用。
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