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公开(公告)号:US20120189554A1
公开(公告)日:2012-07-26
申请号:US13437557
申请日:2012-04-02
CPC分类号: A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译: 制备包含通式(I)和(II)的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这样的聚合物可用于各种药物,靶向,稳定和/或成像剂递送应用。
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公开(公告)号:US20080181852A1
公开(公告)日:2008-07-31
申请号:US12019612
申请日:2008-01-24
IPC分类号: A61K31/337 , A61K47/30 , A61K31/435 , A61K31/70 , A61K49/12 , A61P35/00
CPC分类号: A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译: 制备包含通式(I)和(II)的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这样的聚合物可用于各种药物,靶向,稳定和/或成像剂递送应用。
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公开(公告)号:US20070128118A1
公开(公告)日:2007-06-07
申请号:US11566141
申请日:2006-12-01
申请人: Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
发明人: Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
IPC分类号: A61K49/10 , A61K49/00 , A61K31/785
CPC分类号: A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要: Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译: 制备包含通式(I)和(II)的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。 这些聚合物可用于各种药物,生物分子和成像剂递送应用。
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公开(公告)号:US20130011336A1
公开(公告)日:2013-01-10
申请号:US13063193
申请日:2009-09-11
申请人: Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Xinghe Wang , Jian Liu , Sanjib Kumar Das , Yasunobu Tanaka , Keiko Kajiwara , Hirokazu Takahashi , Miyono Miyazaki
发明人: Yoshiro Niitsu , Lei Yu , Gang Zhao , Sang Van , Xinghe Wang , Jian Liu , Sanjib Kumar Das , Yasunobu Tanaka , Keiko Kajiwara , Hirokazu Takahashi , Miyono Miyazaki
IPC分类号: A61K49/00 , A61K49/04 , A61K49/10 , G01N21/62 , A61K51/06 , A61K49/22 , A61P1/16 , C08G69/48 , C07C403/08 , A61K51/04
CPC分类号: A61K49/085 , A61K49/0002 , A61K49/0041 , A61K49/0052 , A61K49/0054 , A61K49/128 , A61K51/065 , C08G69/10 , C08G69/48
摘要: Agents and methods for imaging a cell and/or a portion of tissue characterized by fibrosis, as well as to agents and methods for determining and/or diagnosing fibrotic diseases are disclosed herein. Also disclosed herein are polymer conjugates that can include a detectable label, a retinoid and a polymer. The polymer conjugates can be used to image a portion of tissue, deliver a detectable label to a portion of tissue or a cell and/or diagnosis a condition or disease.
摘要翻译: 本文公开了用于成像细胞和/或特征在于纤维化的组织的一部分以及用于确定和/或诊断纤维化疾病的药剂和方法的药剂和方法。 本文还公开了可以包括可检测标记,类视色素和聚合物的聚合物缀合物。 聚合物缀合物可用于对组织的一部分进行成像,将可检测标记递送至组织或细胞的一部分和/或诊断病症或疾病。
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公开(公告)号:US20100093935A1
公开(公告)日:2010-04-15
申请号:US12579287
申请日:2009-10-14
申请人: Sang Van , Sanjib Kumar Das , Gang Zhao , Lei Yu
发明人: Sang Van , Sanjib Kumar Das , Gang Zhao , Lei Yu
CPC分类号: A61K47/645
摘要: Methods for preparing and isolating polymer conjugates that include a recurring unit of Formulae (I) and (Ia) are described herein. The polymer conjugates can include an anti-cancer drug.
摘要翻译: 本文描述了制备和分离包含式(I)和(Ia)的重复单元的聚合物缀合物的方法。 聚合物缀合物可以包括抗癌药物。
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公开(公告)号:US20100028416A1
公开(公告)日:2010-02-04
申请号:US12210125
申请日:2008-09-12
IPC分类号: A61K9/127 , A61K31/7088
CPC分类号: A61K47/34 , A61K9/127 , A61K31/00 , A61K31/337 , A61K31/7088 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/36 , A61K47/64
摘要: Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译: 可以包括载体,靶向剂和治疗剂的组合物在本文中公开。 治疗剂可以具有治疗活性,例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。
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公开(公告)号:US07700542B2
公开(公告)日:2010-04-20
申请号:US12014446
申请日:2008-01-15
CPC分类号: C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要: Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译: 包含聚乙烯亚胺,可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。
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公开(公告)号:US07358223B2
公开(公告)日:2008-04-15
申请号:US11216986
申请日:2005-08-31
CPC分类号: C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要: Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译: 包含聚乙烯亚胺,可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。
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公开(公告)号:US08258235B2
公开(公告)日:2012-09-04
申请号:US12707959
申请日:2010-02-18
IPC分类号: B41M5/00
CPC分类号: C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要: Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译: 包含聚乙烯亚胺,可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。
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公开(公告)号:US20100210715A1
公开(公告)日:2010-08-19
申请号:US12707959
申请日:2010-02-18
IPC分类号: A61K31/7088 , C08G73/04 , A61K47/34 , C12N5/00
CPC分类号: C08G73/02 , A61K31/12 , A61K41/0038 , A61K47/59 , A61K47/593 , A61K48/0041 , A61K49/0002 , C08G63/6856 , C08G73/0206 , C08L67/02 , C08L79/02 , C12N15/88 , Y10S977/702 , Y10S977/704 , Y10S977/705 , C08L2666/26
摘要: Polymers comprising a polyethylenimine, a biodegradable group, and a relatively hydrophobic group are useful for the delivery of bioactive agents to cells.
摘要翻译: 包含聚乙烯亚胺,可生物降解基团和相对疏水的基团的聚合物可用于将生物活性剂递送至细胞。
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