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    Pathogen detection using coherent anti-stokes Raman scattering microscopy
    1.
    发明授权
    Pathogen detection using coherent anti-stokes Raman scattering microscopy 有权
    使用相干反斯托克斯拉曼散射显微镜的病原体检测

    公开(公告)号：US07542137B2

    公开(公告)日：2009-06-02

    申请号：US11781602

    申请日：2007-07-23

    申请人： Sangeeta Murugkar ,  Hanan Anis ,  Xiaoliang Sunney Xie ,  Conor Evans

    发明人： Sangeeta Murugkar ,  Hanan Anis ,  Xiaoliang Sunney Xie ,  Conor Evans

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01J3/44 ,  G01J3/4338 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/653

    摘要： The invention provides a system and method for automatic real-time monitoring for the presence of a pathogen in water using coherent anti-stokes Raman scattering (CARS) microscopy. Water sample trapped in a trapping medium is provided to a CARS imager. CARS images are provided to a processor for automatic analyzing for the presence of image artifacts having pre-determined features characteristic to the pathogen. If a match is found, a CARS spectrum is taken and compared to a stored library of reference pathogen-specific spectra for pathogen identification. The system enables automatic pathogen detection in flowing water in real time.

    摘要翻译： 本发明提供一种用于使用相干抗斯托克斯拉曼散射（CARS）显微镜自动实时监测水中病原体存在的系统和方法。 捕获介质中的水样被提供给CARS成像仪。 将CARS图像提供给处理器，用于自动分析具有对病原体特征的预定特征的图像伪影的存在。 如果发现匹配，则采集CARS光谱，并将其与用于病原体鉴定的参考病原体特异性光谱的存储库进行比较。 该系统实时实现流水中的自动病原体检测。

    Phase sensitive heterodyne coherent anti-Stokes Raman scattering micro-spectroscopy and microscopy
    2.
    发明授权
    Phase sensitive heterodyne coherent anti-Stokes Raman scattering micro-spectroscopy and microscopy 有权
    相敏外差相干反斯托克斯拉曼散射微光谱和显微镜

    公开(公告)号：US07388668B2

    公开(公告)日：2008-06-17

    申请号：US11145420

    申请日：2005-06-03

    申请人： Eric O. Potma ,  Conor Evans ,  Xiaoliang Sunney Xie

    发明人： Eric O. Potma ,  Conor Evans ,  Xiaoliang Sunney Xie

    IPC分类号： G01B9/02

    CPC分类号： G01N21/636 ,  G01J3/44 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/656

    摘要： A system is disclosed for detecting a non-linear coherent field induced in a sample volume. The system includes a first source for generating a first electromagnetic field at a first frequency, a second source for generating a second electromagnetic field at a second frequency, first optics for directing the first and second electromagnetic fields toward the sample volume, second optics for directing the first and second electromagnetic fields toward a local oscillator volume, and an interferometer. The interferometer is for interfering a first scattering field that is generated by the interaction of the first and second electromagnetic fields in the sample volume, with a second scattering field that is generated by the interaction of the first and second electromagnetic fields in the local oscillator volume.

    摘要翻译： 公开了一种用于检测样品体积中诱导的非线性相干场的系统。 该系统包括用于产生第一频率的第一电磁场的第一源，用于产生第二频率的第二电磁场的第二源，用于将第一和第二电磁场引向样品体积的第一光学器件，用于引导 朝向本地振荡器体积的第一和第二电磁场以及干涉仪。 干涉仪用于干扰由样品体积中的第一和第二电磁场的相互作用产生的第一散射场与由本地振荡器体积中的第一和第二电磁场的相互作用产生的第二散射场 。

    System and method for coherent anti-Stokes Raman scattering endoscopy
    3.
    发明授权
    System and method for coherent anti-Stokes Raman scattering endoscopy 有权
    相干反斯托克斯拉曼散射内窥镜检查系统和方法

    公开(公告)号：US07414729B2

    公开(公告)日：2008-08-19

    申请号：US11403075

    申请日：2006-04-12

    申请人： Xiaoliang Sunney Xie ,  Francois Légaré ,  Feruz Ganikhanov ,  Conor Evans

    发明人： Xiaoliang Sunney Xie ,  Francois Légaré ,  Feruz Ganikhanov ,  Conor Evans

    IPC分类号： G01B9/02

    CPC分类号： A61B5/6852 ,  A61B5/0066 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/656

    摘要： A system is disclosed for detecting a signal field from a sample volume. The system includes a source system and an optical fiber system. The source system provides a first electromagnetic field at a first frequency and a second electromagnetic field at a second frequency that is different from the first frequency. The optical fiber system includes at least one optical fiber for guiding the first and second electromagnetic fields to the sample volume to generate coherent radiation characteristic of molecular vibrations by non-linear interaction of the first and second fields with the sample volume. The optical fiber system also receives the signal field resulting from the coherent radiation, and guides the signal field to a detector.

    摘要翻译： 公开了一种用于从样本体积检测信号场的系统。 该系统包括源系统和光纤系统。 源系统以与第一频率不同的第二频率提供第一频率处的第一电磁场和第二电磁场。 光纤系统包括用于将第一和第二电磁场引导到样本体积的至少一个光纤，以通过第一和第二场与样本体积的非线性相互作用产生分子振动的相干辐射特性。 光纤系统还接收由相干辐射产生的信号场，并将信号场引导到检测器。

    System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses
    4.
    发明授权
    System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses 有权
    用于高灵敏度振动成像的系统和方法，采用频率调制相干反斯托克斯拉曼散射分析

    公开(公告)号：US07352458B2

    公开(公告)日：2008-04-01

    申请号：US11376396

    申请日：2006-03-15

    申请人： Xiaoliang Sunney Xie ,  Feruz Ganikhanov ,  Conor Evans

    发明人： Xiaoliang Sunney Xie ,  Feruz Ganikhanov ,  Conor Evans

    IPC分类号： G01J3/44

    CPC分类号： G01J3/44 ,  G01J3/433 ,  G01N21/636 ,  G01N21/65 ,  G01N2021/1757 ,  G01N2021/653

    摘要： A system is disclosed for detecting a nonlinear coherent field induced in a sample. The system includes optics, a modulation system, and a detector system. The optics are for directing a first electromagnetic field at a first frequency ω1 and a second electromagnetic field at a second frequency ω2 toward a focal volume such that a difference frequency ω1–ω2 is resonant with a vibrational frequency of a sample in the focal volume. The modulation system is for modulating the difference frequency ω1–ω2 such that the difference frequency ω1–ω2 is tuned in and out of the vibrational frequency of the sample of at a modulation frequency. The detector system is for detecting an optical field that is generated through non-linear interaction of ω1 and ω2 and the sample responsive to the modulation frequency.

    摘要翻译： 公开了一种用于检测样品中引起的非线性相干场的系统。 该系统包括光学器件，调制系统和检测器系统。 所述光学器件用于将第一频率ω1> 1的第一电磁场和第二频率ω2 <2>的第二电磁场引向焦点体积，使得差频ω ＆lt; 1＆gt; -omega 2＆lt; 2＆gt;与焦点体积中的样本的振动频率共振。 调制系统用于调制差分频率ω1-ω2-ω2，使得差频ω1-ω2大于2 / SUB>被调谐出调制频率的样本的振动频率。 检测器系统用于检测通过ω1和ω2 2 N的非线性相互作用产生的光场，以及响应调制频率的样本。

    SYSTEMS AND METHODS FOR SELECTIVE DETECTION AND IMAGING IN COHERENT RAMAN MICROSCOPY BY SPECTRAL-TEMPORAL EXCITATION SHAPING
    7.
    发明申请
    SYSTEMS AND METHODS FOR SELECTIVE DETECTION AND IMAGING IN COHERENT RAMAN MICROSCOPY BY SPECTRAL-TEMPORAL EXCITATION SHAPING 有权
    通过光谱激发成像在相干拉曼显微镜中选择性检测和成像的系统和方法

    公开(公告)号：US20100188496A1

    公开(公告)日：2010-07-29

    申请号：US12690579

    申请日：2010-01-20

    申请人： Xiaoliang Sunney Xie ,  Christian Freudiger ,  Wei Min

    发明人： Xiaoliang Sunney Xie ,  Christian Freudiger ,  Wei Min

    IPC分类号： H04N7/18

    CPC分类号： G02B21/002 ,  G01J3/10 ,  G01J3/44 ,  G01J2003/1282 ,  G01N21/65 ,  G01N2021/653 ,  G01N2021/655 ,  G01N2201/0675 ,  G02B21/082

    摘要： A microscopy imaging system is disclosed that includes a light source system, a spectral shaper, a modulator system, an optics system, an optical detector and a processor. The light source system is for providing a first train of pulses and a second train of pulses. The spectral shaper is for spectrally modifying an optical property of at least some frequency components of the broadband range of frequency components such that the broadband range of frequency components is shaped producing a shaped first train of pulses to specifically probe a spectral feature of interest from a sample, and to reduce information from features that are not of interest from the sample. The modulator system is for modulating a property of at least one of the shaped first train of pulses and the second train of pulses at a modulation frequency. The optical detector is for detecting an integrated intensity of substantially all optical frequency components of a train of pulses of interest transmitted or reflected through the common focal volume. The processor is for detecting a modulation at the modulation frequency of the integrated intensity of substantially all of the optical frequency components of the train of pulses of interest due to the non-linear interaction of the shaped first train of pulses with the second train of pulses as modulated in the common focal volume, and for providing an output signal for a pixel of an image for the microscopy imaging system.

    摘要翻译： 公开了一种显微镜成像系统，其包括光源系统，光谱整形器，调制器系统，光学系统，光学检测器和处理器。 光源系统用于提供第一脉冲串和第二脉冲串。 频谱整形器用于频谱修改频率分量的宽带范围的至少一些频率分量的光学特性，使得频率分量的宽带范围成形，产生成形的第一脉冲串，从而特别地探测来自 样本，并从样本中不感兴趣的特征中减少信息。 调制器系统用于以调制频率调制成形的第一脉冲序列和第二脉冲串中的至少一个的性质。 光学检测器用于检测通过公共焦点体积传输或反射的感兴趣的脉冲串的基本上所有的光学频率分量的积分强度。 处理器用于检测由于成形的第一脉冲序列与第二脉冲串的非线性相互作用而导致的感兴趣的脉冲串的基本上所有的光学频率分量的积分强度的调制频率的调制 在公共焦点体积中调制，并且为显微镜成像系统提供用于图像的像素的输出信号。

    System and method for providing a tunable optical parametric oscillator laser system that provides dual frequency output for non-linear vibrational spectroscopy and microscopy
    8.
    发明授权
    System and method for providing a tunable optical parametric oscillator laser system that provides dual frequency output for non-linear vibrational spectroscopy and microscopy 有权
    用于提供可调谐光参量振荡器激光系统的系统和方法，其提供用于非线性振动光谱和显微镜的双频输出

    公开(公告)号：US07616304B2

    公开(公告)日：2009-11-10

    申请号：US11778838

    申请日：2007-07-17

    申请人： Feruz Gankkhanov ,  Silvia Carrasco ,  Xiaoliang Sunney Xie

    发明人： Feruz Gankkhanov ,  Silvia Carrasco ,  Xiaoliang Sunney Xie

    IPC分类号： G01J3/44

    CPC分类号： G01J3/44 ,  G01J3/10 ,  G01N2021/653 ,  G01N2021/655 ,  G02F1/39

    摘要： A system is disclosed for providing a first electromagnetic field and a second electromagnetic field to vibrational analysis equipment that is responsive to a difference between first and second frequencies of the first and second electromagnetic fields respectively. The system includes a non-linear crystal that may be pumped at a high repetition rate to provide a pulsed signal field at a signal field frequency and a pulsed idler field at an idler field frequency as output. The signal field provides the first electromagnetic field and the idler field provides the second electromagnetic field. The system also includes a tuning system for permitting the difference between the signal field frequency and the idler field frequency to be changed. The system also includes an output unit for providing the first and second electromagnetic fields to the vibrational analysis equipment.

    摘要翻译： 公开了一种用于向分别响应于第一和第二电磁场的第一和第二频率之间的差异的振动分析设备提供第一电磁场和第二电磁场的系统。 该系统包括可以以高重复率泵浦的非线性晶体，以在信号场频率提供脉冲信号场，以及以惰轮频率的脉冲惰轮场作为输出。 信号场提供第一电磁场，空载场提供第二电磁场。 该系统还包括用于允许改变信号场频率和惰轮频率之间的差的调谐系统。 该系统还包括用于向振动分析设备提供第一和第二电磁场的输出单元。