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公开(公告)号：US20050272680A1
公开(公告)日：2005-12-08
申请号：US11066725
申请日：2005-02-24
申请人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu , Brett Monia
发明人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu , Brett Monia
IPC分类号： C07H21/02 , C12N15/113 , A61K48/00
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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公开(公告)号：US20050227939A1
公开(公告)日：2005-10-13
申请号：US11036095
申请日：2005-01-14
申请人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21034 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节激肽释放酶6的表达。该组合物包含靶向编码激肽释放酶的核酸的寡核苷酸。6.使用这些化合物调节激肽释放酶6表达并用于诊断和治疗与表达相关的疾病的方法 提供激肽释放酶6。
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公开(公告)号：US20050181400A1
公开(公告)日：2005-08-18
申请号：US11042768
申请日：2005-01-24
申请人： Brett Monia , Sanjay Bhanot , Kenneth Dobie , Ravi Jain
发明人： Brett Monia , Sanjay Bhanot , Kenneth Dobie , Ravi Jain
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68 , A61K48/00
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of using these compounds for modulation of eIF4E-BP1 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP1 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP1的表达。 组合物包含靶向编码eIF4E-BP1的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP1表达和用于诊断和治疗与eIF4E-BP1表达相关的疾病和病症的方法。
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公开(公告)号：US20050164254A1
公开(公告)日：2005-07-28
申请号：US11010227
申请日：2004-12-09
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
摘要翻译： 提供化合物，组合物和方法用于调节adipophilin的表达。 组合物包含针对编码脂肪蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节脂肪蛋白表达和用于诊断和治疗与亲脂素表达相关的疾病和病症的方法。
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公开(公告)号：US20060074043A1
公开(公告)日：2006-04-06
申请号：US11250884
申请日：2005-10-13
申请人： Brett Monia , Susan Freier , Sanjay Bhanot , Madeline Butler , Andrew Watt , Jacqueline Wyatt , Brenda Baker , Lex Cowsert , Kenneth Dobie
发明人： Brett Monia , Susan Freier , Sanjay Bhanot , Madeline Butler , Andrew Watt , Jacqueline Wyatt , Brenda Baker , Lex Cowsert , Kenneth Dobie
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.
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公开(公告)号：US20060025372A1
公开(公告)日：2006-02-02
申请号：US11194776
申请日：2005-08-01
申请人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
发明人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US20070087987A1
公开(公告)日：2007-04-19
申请号：US11524041
申请日：2006-09-19
申请人： Brett Monia , Susan Freier , Sanjay Bhanot
发明人： Brett Monia , Susan Freier , Sanjay Bhanot
CPC分类号： C12N15/1138 , A61K31/712 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for treatment of diseases are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含靶向编码胰高血糖素受体的核酸的反义化合物，特别是具有特定体内特性的反义寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和治疗疾病的方法。
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公开(公告)号：US20060063730A1
公开(公告)日：2006-03-23
申请号：US11231243
申请日：2005-09-19
申请人： Brett Monia , Andrew Siwkowski , Sanjay Bhanot
发明人： Brett Monia , Andrew Siwkowski , Sanjay Bhanot
CPC分类号： C12N15/111 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2320/50 , C12N2310/3525
摘要： Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.
摘要翻译： 与相同序列的5-10-5个MOE gapmer反义寡核苷酸相比，本文描述了具有改善的治疗指数的间隙扩大的反义寡核苷酸。 还描述了使用本发明的间隙加宽的反义寡核苷酸还原动物中的靶RNA的方法。 此外，是选择间隙扩大的反义寡核苷酸的方法。
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公开(公告)号：US20080015162A1
公开(公告)日：2008-01-17
申请号：US11745429
申请日：2007-05-07
申请人： Sanjay Bhanot , Richard Geary , Robert McKay , Brett Monia , Punit Seth , Andrew Siwkowski , Eric Swayze , Edward Wancewicz
发明人： Sanjay Bhanot , Richard Geary , Robert McKay , Brett Monia , Punit Seth , Andrew Siwkowski , Eric Swayze , Edward Wancewicz
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/31 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/3515 , C12Y203/0102 , C12N2310/3521
摘要： The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.
摘要翻译： 本公开描述了短反义化合物，包括长度为化学修饰的高亲和力单体8-16单体的这类化合物。 某些这样的短反义化合物可用于在增加的效力和改善的治疗指数的细胞，组织和动物中还原靶核酸和/或蛋白质。 因此，本文提供了包含用于在体内降低靶RNA的高亲和力核苷酸修饰的短反义化合物。 这样的短反义化合物在比以前描述的反义化合物低的剂量下是有效的，允许降低毒性和治疗成本。 此外，所述短反义化合物具有更大的口服给药潜力。
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