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公开(公告)号：US20050272680A1
公开(公告)日：2005-12-08
申请号：US11066725
申请日：2005-02-24
申请人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu , Brett Monia
发明人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu , Brett Monia
IPC分类号： C07H21/02 , C12N15/113 , A61K48/00
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病的方法 提供了与二酰基甘油酰基转移酶2的表达相关的病症。
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公开(公告)号：US20050043524A1
公开(公告)日：2005-02-24
申请号：US10643801
申请日：2003-08-18
申请人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu
发明人： Sanjay Bhanot , Kenneth Dobie , Xing-Xian Yu
IPC分类号： C07H21/02 , C12N15/113 , A61K48/00
CPC分类号： C12N15/1137 , C07H21/02 , C12N2310/11 , C12N2310/14
摘要： Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of disease associated with expression of diacylglycerol acyltransferase 2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节二酰基甘油酰基转移酶2的表达。该组合物包含靶向编码二酰基甘油酰基转移酶的核酸的寡核苷酸2.使用这些化合物调节二酰基甘油酰基转移酶2表达并用于诊断和治疗疾病相关的方法 提供二酰基甘油酰基转移酶2的表达。
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公开(公告)号：US20060154885A1
公开(公告)日：2006-07-13
申请号：US11072846
申请日：2005-03-04
申请人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
发明人： C. Bennett , Brett Monia , Nicholas Dean , Xiaoxing Xu , Sanjay Bhanot , Brenda Baker , Susan Freier , Lex Cowsert , Robert McKay , Muthiah Manoharan , F. Dorr , Jon Holmlund , Alexander Borchers , Vickie Brown-Driver , Jacqueline Wyatt , Shin Flournoy , Elizabeth Ackermann , Hong Zhang , Andrew Watt , Eric Maracusson , Scott Cooper , Erich Koller , Loren Miraglia , William Ricketts , Kenneth Dobie , Tamara Sipes
CPC分类号： C12N15/1138 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of SLC26A2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding SLC26A2. Methods of using these compounds for modulation of SLC26A2 expression and for diagnosis and treatment of disease associated with expression of SLC26A2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节SLC26A2的表达。 组合物包含针对编码SLC26A2的核酸的寡核苷酸。 提供了使用这些化合物调节SLC26A2表达和用于诊断和治疗与SLC26A2表达相关的疾病的方法。
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公开(公告)号：US20050227939A1
公开(公告)日：2005-10-13
申请号：US11036095
申请日：2005-01-14
申请人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
发明人： C. Bennett , Brett Monia , Nicholas Dean , Sanjay Bhanot , Donna Ward , Lex Cowsert , Kenneth Dobie
IPC分类号： A61K48/00 , C07H21/02 , C12N15/113
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/21034 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of kallikrein 6. The compositions comprise oligonucleotides, targeted to nucleic acid encoding kallikrein 6. Methods of using these compounds for modulation of kallikrein 6 expression and for diagnosis and treatment of disease associated with expression of kallikrein 6 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节激肽释放酶6的表达。该组合物包含靶向编码激肽释放酶的核酸的寡核苷酸。6.使用这些化合物调节激肽释放酶6表达并用于诊断和治疗与表达相关的疾病的方法 提供激肽释放酶6。
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公开(公告)号：US20050181400A1
公开(公告)日：2005-08-18
申请号：US11042768
申请日：2005-01-24
申请人： Brett Monia , Sanjay Bhanot , Kenneth Dobie , Ravi Jain
发明人： Brett Monia , Sanjay Bhanot , Kenneth Dobie , Ravi Jain
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68 , A61K48/00
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP1. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP1. Methods of using these compounds for modulation of eIF4E-BP1 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP1 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP1的表达。 组合物包含靶向编码eIF4E-BP1的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP1表达和用于诊断和治疗与eIF4E-BP1表达相关的疾病和病症的方法。
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公开(公告)号：US20050164254A1
公开(公告)日：2005-07-28
申请号：US11010227
申请日：2004-12-09
申请人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
发明人： C. Bennett , Brett Monia , Nicholas Dean , Susan Freier , Sanjay Bhanot , Donna Ward , Alexander Borchers , Tamara Sipes , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/341 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of adipophilin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding adipophilin. Methods of using these compounds for modulation of adipophilin expression and for diagnosis and treatment of diseases and conditions associated with expression of adipophilin are provided.
摘要翻译： 提供化合物，组合物和方法用于调节adipophilin的表达。 组合物包含针对编码脂肪蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节脂肪蛋白表达和用于诊断和治疗与亲脂素表达相关的疾病和病症的方法。
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公开(公告)号：US20060074043A1
公开(公告)日：2006-04-06
申请号：US11250884
申请日：2005-10-13
申请人： Brett Monia , Susan Freier , Sanjay Bhanot , Madeline Butler , Andrew Watt , Jacqueline Wyatt , Brenda Baker , Lex Cowsert , Kenneth Dobie
发明人： Brett Monia , Susan Freier , Sanjay Bhanot , Madeline Butler , Andrew Watt , Jacqueline Wyatt , Brenda Baker , Lex Cowsert , Kenneth Dobie
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of matrix metalloproteinase 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding matrix metalloproteinase 1. Methods of using these compounds for modulation of matrix metalloproteinase 1 expression and for treatment of diseases associated with expression of matrix metalloproteinase 1 are provided.
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公开(公告)号：US20060025372A1
公开(公告)日：2006-02-02
申请号：US11194776
申请日：2005-08-01
申请人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
发明人： Sanjay Bhanot , Lex Cowsert , Jacqueline Wyatt , Brett Monia , Madelline Butler , Robert McKay , Susan Freier , Kenneth Dobie
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
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公开(公告)号：US20060025373A1
公开(公告)日：2006-02-02
申请号：US11207478
申请日：2005-08-18
申请人： Sanjay Bhanot , Kenneth Dobie , Susan Freier
发明人： Sanjay Bhanot , Kenneth Dobie , Susan Freier
CPC分类号： C07H21/04 , A61K38/00 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for diagnosis and treatment of diseases and conditions associated with expression of glucocorticoid receptor are provided.
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公开(公告)号：US20050196787A1
公开(公告)日：2005-09-08
申请号：US11042899
申请日：2005-01-24
申请人： Sanjay Bhanot , Kenneth Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth Dobie , Ravi Jain
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP2的表达。 组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达和用于诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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