公开(公告)号：US20230201781A1

公开(公告)日：2023-06-29

申请号：US18174988

申请日：2023-02-27

Applicant: SARTORIUS STEDIM BIOTECH GMBH

Inventor： Thomas DREHER ,  Alexandre ESPACHS BARROSO ,  Michael GOHS ,  Alexander HALT ,  Bjoern NICKEL

IPC: B01F35/21 ,  B01F35/22 ,  B01F35/221

CPC classification number: B01F35/2113 ,  B01F35/2202 ,  B01F35/2211 ,  B01F2101/22

Abstract: A safety device for a single-use mixing or storage system (10), especially for use in a biopharmaceutical process, includes a flexible bag (12) made from a film material and a support structure (14) receiving and supporting the bag (12) in several directions. The support structure (14) allows an expansion of the bag (12) in an expansion direction. The safety device further includes a detection unit (20) adapted to detect an expansion of the bag (12) in the expansion direction, and a control unit (28) connected to the detection unit (20) and adapted to initiate a safety measure in response to the expansion of the bag (12) in the expansion direction exceeds a given threshold.

公开(公告)号：US20230256407A1

公开(公告)日：2023-08-17

申请号：US18015934

申请日：2021-07-02

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Thomas DREHER ,  Alexandre ESPACHS BARROSO ,  Michael GOHS ,  Alexander HALT ,  Björn NICKEL

IPC: B01J19/00 ,  B01D61/14 ,  B01J19/02

CPC classification number: B01J19/004 ,  B01D61/145 ,  B01J19/02 ,  B01J19/0013 ,  B01D2315/16

Abstract: A device assembly for producing bioconjugates, in particular antibody-drug conjugates, including a conjugation unit for performing a bioconjugation reaction in a medium, a first filtration unit for separating precipitates and/or agglomerates, and a second filtration unit for performing an ultrafiltration and/or a diafiltration process. The first filtration unit is arranged in a flow path between the conjugation unit and the second filtration unit. The device assembly further includes a single control unit for controlling the transfer of medium from the conjugation unit through the first filtration unit to the second filtration unit and for controlling the ultrafiltration and/or diafiltration process.