公开(公告)号：US20230201781A1

公开(公告)日：2023-06-29

申请号：US18174988

申请日：2023-02-27

Applicant: SARTORIUS STEDIM BIOTECH GMBH

Inventor： Thomas DREHER ,  Alexandre ESPACHS BARROSO ,  Michael GOHS ,  Alexander HALT ,  Bjoern NICKEL

IPC: B01F35/21 ,  B01F35/22 ,  B01F35/221

CPC classification number: B01F35/2113 ,  B01F35/2202 ,  B01F35/2211 ,  B01F2101/22

Abstract: A safety device for a single-use mixing or storage system (10), especially for use in a biopharmaceutical process, includes a flexible bag (12) made from a film material and a support structure (14) receiving and supporting the bag (12) in several directions. The support structure (14) allows an expansion of the bag (12) in an expansion direction. The safety device further includes a detection unit (20) adapted to detect an expansion of the bag (12) in the expansion direction, and a control unit (28) connected to the detection unit (20) and adapted to initiate a safety measure in response to the expansion of the bag (12) in the expansion direction exceeds a given threshold.

公开(公告)号：US20220195372A1

公开(公告)日：2022-06-23

申请号：US17606109

申请日：2020-04-15

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Thomas REGEN ,  Jochen SCHOLZ ,  Thomas DREHER ,  Regina WOLLSCHMIDT ,  Sascha GAERTNER ,  Jan-Eike SCHUBERT ,  Ute HUSEMANN ,  Sabrina HILDEBRANDT ,  Andrea FRIESER ,  Sharon-Angela ALTHUBER ,  Sebastian PURMANN

IPC: C12M1/12 ,  C12M1/00

Abstract: A device for mechanically stabilizing a sensor port on a flexible bag including a rigid, substantially plate-shaped support part, which has a receptacle for a rigid connecting part integrated in the bag, in particular a sensor, and a holding mechanism on the receptacle. The device further includes a fastening element adapted to be attached to the holding mechanism of the support part such that it fixes the support part to the connecting part. The device may include a rigid support part which can be assembled from at least two parts, preferably struts. The parts surround a free area or an opening in which a rigid connecting part integrated in the bag can be placed. In an assembled state of the parts, the free area or the opening has a smaller diameter than the connecting part, so that the parts form a load-receiving mechanism for the connecting part.

公开(公告)号：US20230256407A1

公开(公告)日：2023-08-17

申请号：US18015934

申请日：2021-07-02

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Thomas DREHER ,  Alexandre ESPACHS BARROSO ,  Michael GOHS ,  Alexander HALT ,  Björn NICKEL

IPC: B01J19/00 ,  B01D61/14 ,  B01J19/02

CPC classification number: B01J19/004 ,  B01D61/145 ,  B01J19/02 ,  B01J19/0013 ,  B01D2315/16

Abstract: A device assembly for producing bioconjugates, in particular antibody-drug conjugates, including a conjugation unit for performing a bioconjugation reaction in a medium, a first filtration unit for separating precipitates and/or agglomerates, and a second filtration unit for performing an ultrafiltration and/or a diafiltration process. The first filtration unit is arranged in a flow path between the conjugation unit and the second filtration unit. The device assembly further includes a single control unit for controlling the transfer of medium from the conjugation unit through the first filtration unit to the second filtration unit and for controlling the ultrafiltration and/or diafiltration process.

公开(公告)号：US20160023172A1

公开(公告)日：2016-01-28

申请号：US14876293

申请日：2015-10-06

Applicant: Sartorius Stedim Biotech GmbH

Inventor： Oscar-Werner REIF ,  Gerhard GRELLER ,  Ute HUSEMANN ,  Thomas DREHER ,  Oliver SCHEIBE

IPC: B01F7/00 ,  B01F15/00

CPC classification number: B01F7/00341 ,  B01F7/001 ,  B01F7/06 ,  B01F15/00675 ,  B29L2031/087 ,  F04D29/34 ,  F04D29/36 ,  F04D29/388 ,  Y10T29/49321 ,  Y10T29/49327

Abstract: A device and a method for adjusting stirring blades on a stirring blade receptacle of a stirrer, wherein the stirring blades can be fixed with a stirring blade axis in receiving bores, which are arranged transversely to an axis of rotation and are a part of the stirring blade receptacle, at intended predetermined angle of attack relative to a virtual plane that is arranged transversely to the axis of rotation of the stirrer. An associated device body is provided with a receiving element for receiving the stirring blade receptacle with unfixed stirring blades. A stop is arranged on the device body for each lower face, which faces the receiving element and is a part of the stirring blades, outside the respective stirring blade axis. Each respective stirring blade is then brought into abutment against its associated stop, to place it into the predetermined angle of attack.

Abstract translation: 一种用于在搅拌器的搅拌叶片容器上调节搅拌叶片的装置和方法，其中搅拌叶片可以在接收孔中以搅拌叶片轴线固定，所述搅拌叶片轴线横向于旋转轴线布置，并且是搅拌器的一部分 叶片容器相对于横向于搅拌器的旋转轴线布置的虚拟平面以预定的预定攻角。 相关联的装置主体设置有用于接收具有未固定搅拌叶片的搅拌叶片容器的接收元件。 在各个搅拌叶片轴线外侧的每个下表面上设置有与接收元件面对并且是搅拌叶片的一部分的止动件。 然后将每个相应的搅拌叶片与其相关的止挡件抵接，以将其置于预定的迎角。