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公开(公告)号：US09669333B2
公开(公告)日：2017-06-06
申请号：US14376490
申请日：2013-02-08
CPC分类号： B01D29/05 , B01D29/56 , B01D63/082 , B01D65/003 , B01D2313/04 , B01D2313/06 , B01D2313/19 , B01D2319/025
摘要： One aspect of the invention relates to a filter module comprising: —a filter element having at least one filter medium which separates a filtrate side and a retentate side of the filter element from one another, and having a filter medium holder to which the filter medium is attached and which has at least one holder intake channel and at least one holder discharge channel, —a first filter cartridge part having at least one first cartridge intake channel and at least one first cartridge discharge channel, —a second filter cartridge channel having at least one second cartridge intake channel and at least one second cartridge discharge channel, wherein the filter medium holder is arranged in an arrangement position between the first filter cartridge part and the second filter cartridge part in a fluid-tight manner, wherein the at least one holder intake channel has a fluid connection with the at least one first cartridge intake channel and the at least one second cartridge intake channel, in order to form a module intake channel, wherein the at least one holder discharge channel has a fluid connection with the at least one first cartridge discharge channel and the at least one second cartridge discharge channel, in order to form a module discharge channel, wherein the module intake channel has a fluid connection with the retentate side of the filter medium and wherein the module discharge channel has a fluid connection with the filtrate side of the filter medium, and a modular filter system.
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公开(公告)号：USD741983S1
公开(公告)日：2015-10-27
申请号：US29499147
申请日：2014-08-12
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公开(公告)号：US11794154B2
公开(公告)日：2023-10-24
申请号：US16785789
申请日：2020-02-10
发明人： Stefan Zeuch , Markus Haeusser , Stefan Weisshaar , Jens Ludwig
IPC分类号： B01F27/09 , B01F27/808 , B01F27/90 , B01F35/513 , B01F35/30
CPC分类号： B01F27/808 , B01F27/90 , B01F35/513 , B01F2035/3513
摘要： A mixing apparatus (1) for mixing a fluid and/or solid. The mixing apparatus includes a mixing container (100) having an interior in which the fluid and/or solid can be arranged. A feed-through passage (10) extends through a container wall (101) of the mixing container. A drive shaft (50) is fed through the feed-through passage, to drive a stirring element (30) arranged at least partly in the interior of the mixing container. The stirring element is used to mix the fluid and/or solid arranged in the mixing container. A drive-side shaft end (51) of the drive shaft couples the drive shaft to a drive (120) arranged outside of the mixing container. An adjustable seal (70) seals off the feed-through passage. A setting apparatus (80) is provided to switch the adjustable seal into at least two sealing operation states having different sealing effects.
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公开(公告)号：USD740391S1
公开(公告)日：2015-10-06
申请号：US29499144
申请日：2014-08-12
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公开(公告)号：US20240182840A1
公开(公告)日：2024-06-06
申请号：US18283403
申请日：2022-03-21
发明人： Jan Schaefer , Stefan Weisshaar , Alexander Helling , Mario Deuse , Bernhard Diel , Alexander Tappe
摘要： Embodiments include a device for continuous virus inactivation during a protein production process comprising a first and a second fluid inlet, a first mixer, and a fluid outlet. A first liquid stream containing a target protein is introducible into the device through the first fluid inlet and is combinable in a predefined volume ratio with a second, virus-inactivating liquid stream introducible into the device through the second fluid inlet to form a third, reactive liquid stream which is conducted through the first mixer for mixing in order to generate predefined, virus-inactivating conditions. The device further comprises a head part and, downstream of the first mixer and upstream of the fluid outlet, a residence time arrangement fluidically connected to the head part for provision of a minimum residence time of the third stream, wherein the head part and the residence time arrangement are rigidly fastened to each other.
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公开(公告)号：US11993768B2
公开(公告)日：2024-05-28
申请号：US17126591
申请日：2020-12-18
发明人： Martin Leuthold , Stefan Weisshaar
摘要： A modular processing system (100) for biopharmaceutical processes includes (i) at least one first and at least one second processing unit (30, 32), which can be fluidically connected to each other; and (ii) at least one adapter plate (200), through which at least one fluid flow (14), flowing from the first processing unit (30) to the second processing unit (32), can flow. The adapter plate deflects the fluid flow between the first processing unit and the second processing unit at least partially; and/or controls the fluid flow, preferably, the pressure thereof, in an open loop or closed loop manner. A method for the modular construction of a processing system (100) for biopharmaceutical processes is also disclosed.
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公开(公告)号：US20160288054A1
公开(公告)日：2016-10-06
申请号：US15035764
申请日：2014-10-30
发明人： Thomas Krumbein , Stefan Weisshaar , Michael Bates
CPC分类号： B01D63/082 , B01D65/00 , B01D2313/02 , B01D2313/025 , F16B5/0642 , F16B5/065
摘要： A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).
摘要翻译： 连接系统（1）具有用于过滤器盒（4）的至少一个连接器（2），该连接器可以插入到过滤器保持器中，并且在两个端板（6）之间具有过滤层（5） 过滤层（5）和/或端板（6）和相邻过滤层（5）之间。 连接器具有以可纵向移位的方式彼此接合的张紧部件，并且可以通过其端部彼此背离而固定到端板（6）。 当连接器偏转到最大程度时，连接器对端板（6）施加预张紧力。 预张力将端板（6）拉向过滤层（5），并且当将叠加在预张紧力上的接触压力施加到端板（6）上时，张紧部件可以相应地彼此推动 与端板（6）。
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公开(公告)号：US20150001147A1
公开(公告)日：2015-01-01
申请号：US14376490
申请日：2013-02-08
CPC分类号： B01D29/05 , B01D29/56 , B01D63/082 , B01D65/003 , B01D2313/04 , B01D2313/06 , B01D2313/19 , B01D2319/025
摘要： One aspect of the invention relates to a filter module comprising: —a filter element having at least one filter medium which separates a filtrate side and a retentate side of the filter element from one another, and having a filter medium holder to which the filter medium is attached and which has at least one holder intake channel and at least one holder discharge channel, —a first filter cartridge part having at least one first cartridge intake channel and at least one first cartridge discharge channel, —a second filter cartridge channel having at least one second cartridge intake channel and at least one second cartridge discharge channel, wherein the filter medium holder is arranged in an arrangement position between the first filter cartridge part and the second filter cartridge part in a fluid-tight manner, wherein the at least one holder intake channel has a fluid connection with the at least one first cartridge intake channel and the at least one second cartridge intake channel, in order to form a module intake channel, wherein the at least one holder discharge channel has a fluid connection with the at least one first cartridge discharge channel and the at least one second cartridge discharge channel, in order to form a module discharge channel, wherein the module intake channel has a fluid connection with the retentate side of the filter medium and wherein the module discharge channel has a fluid connection with the filtrate side of the filter medium, and a modular filter system.
摘要翻译： 本发明的一个方面涉及一种过滤器模块，其包括：一个过滤元件，其具有至少一个过滤介质，该过滤介质将过滤元件的滤液侧和滞留侧彼此分离，并具有过滤介质保持器，过滤介质 被附接并且具有至少一个保持器进入通道和至少一个保持器排出通道， - 第一过滤器滤芯部件，其具有至少一个第一盒式进样通道和至少一个第一盒式排出通道， - 第二过滤器滤芯通道， 至少一个第二墨盒进气通道和至少一个第二墨盒排出通道，其中所述过滤介质保持器以流体密封的方式布置在所述第一过滤器滤芯部件和所述第二过滤器滤芯部件之间的布置位置，其中所述至少一个 夹持器进气通道与至少一个第一墨盒进气通道和至少一个第二墨盒进样口c具有流体连接 通道，以便形成模块进入通道，其中所述至少一个保持器排出通道与所述至少一个第一盒排出通道和所述至少一个第二盒排出通道具有流体连接，以形成模块排出通道 ，其中所述模块进入通道与所述过滤介质的滞留侧具有流体连接，并且其中所述模块排出通道与所述过滤介质的滤液侧具有流体连接，以及模块化过滤器系统。
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公开(公告)号：USD895059S1
公开(公告)日：2020-09-01
申请号：US29641961
申请日：2018-03-26
设计人： Thomas Krumbein , Stefan Weisshaar , Michael Bates
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公开(公告)号：US10525413B2
公开(公告)日：2020-01-07
申请号：US15035764
申请日：2014-10-30
发明人： Thomas Krumbein , Stefan Weisshaar , Michael Bates
摘要： A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).
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