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公开(公告)号：US20120103052A1
公开(公告)日：2012-05-03
申请号：US13260870
申请日：2010-03-25
IPC分类号： B21B45/02
CPC分类号： B21B45/0233 , B21B45/0218
摘要： A hot rolled steel sheet cooling apparatus includes a gradual cooling header 2 including a rod-like cooling water nozzle 3 for gradual cooling and a rapid cooling header 4 including a rod-like cooling water nozzle 5 for rapid cooling such that the headers constitute a cooling unit 9. The cooling unit 9 includes an elevating unit 7 capable of moving upward and downward in unison with the cooling unit. In cooling the upper surface of a hot rolled steel sheet (hot rolled steel strip or steel plate), uniform and stable cooling is achieved while both of high cooling rate and low cooling rate are ensured.
摘要翻译： 热轧钢板冷却装置包括逐渐冷却集管2，其包括用于逐渐冷却的棒状冷却水喷嘴3和包括用于快速冷却的棒状冷却水喷嘴5的快速冷却集管4，使得集管构成冷却 冷却单元9包括能够与冷却单元一致地向上和向下移动的升降单元7。 在冷轧热轧钢板（热轧钢带或钢板）的上表面时，能够确保高冷却速度和低冷却速度的均匀稳定的冷却。
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公开(公告)号：US08931321B2
公开(公告)日：2015-01-13
申请号：US13260870
申请日：2010-03-25
CPC分类号： B21B45/0233 , B21B45/0218
摘要： A hot rolled steel sheet cooling apparatus includes a gradual cooling header 2 including a rod-like cooling water nozzle 3 for gradual cooling and a rapid cooling header 4 including a rod-like cooling water nozzle 5 for rapid cooling such that the headers constitute a cooling unit 9. The cooling unit 9 includes an elevating unit 7 capable of moving upward and downward in unison with the cooling unit. In cooling the upper surface of a hot rolled steel sheet (hot rolled steel strip or steel plate), uniform and stable cooling is achieved while both of high cooling rate and low cooling rate are ensured.
摘要翻译： 热轧钢板冷却装置包括逐渐冷却集管2，其包括用于逐渐冷却的棒状冷却水喷嘴3和包括用于快速冷却的棒状冷却水喷嘴5的快速冷却集管4，使得集管构成冷却 冷却单元9包括能够与冷却单元一致地向上和向下移动的升降单元7。 在冷轧热轧钢板（热轧钢带或钢板）的上表面时，能够确保高冷却速度和低冷却速度的均匀稳定的冷却。
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公开(公告)号：US10455648B2
公开(公告)日：2019-10-22
申请号：US14127735
申请日：2012-07-25
申请人： Yoshimichi Hino , Hirokazu Sugihara
发明人： Yoshimichi Hino , Hirokazu Sugihara
摘要： The invention proposes a method for heating a steel sheet wherein the generation of buckling can be prevented regardless of presence or absence of rolls restraining the steel sheet by antecedently heating the widthwise central portion of the steel sheet with a solenoid type induction heating coil having a convex form projected onto the surface of the steel sheet toward an upstream side in rapidly heating the continuously traveling steel sheet, whereby an isotherm of the steel sheet in the heating is a convex form toward the upstream side, so that a large wrinkle is generated on the steel sheet, and also proposes a heating apparatus used in this method.
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4.发明授权Measurement device and method for measuring electric signal from biological sample 有权用于测量生物样品电信号的测量装置和方法公开(公告)号：US07462324B2
公开(公告)日：2008-12-09
申请号：US10495621
申请日：2002-11-19
申请人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
发明人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
CPC分类号： G01N33/48707 , B01L3/5027
摘要： A measurement device 10 includes a measurement cell 11. The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17. The substrates 16 and 17 are bonded to each other. Thus, a flow pass 9 is formed in the measurement cell 11. As shown in FIG. 3, on the substrate 17 of the measurement cell 11, provided are a concave well 19, a protruding microelectrode 1 connected to a terminal 4a and formed on a side wall surface of the well 19, communicating tubes 15a and 15b connected to both of side surfaces of the well 19 (i.e., the flow pass 9) to face to each other, resistance baths 6a and 6b connected to the communicating tubes 15a and 15b, thin film resistors 3a and 3b arranged in the resistance baths 6a and 6b, and a reference electrode 2 connected to a terminal 4b.
摘要翻译： 测量装置10包括测量单元11.测量单元11包括基板17和形成在基板17上的基板16.基板16和17彼此接合。 因此，在测量单元11中形成流路9。 如图3所示，在测量单元11的基板17上设置凹槽19，连接到端子4a并形成在井19的侧壁表面上的突出微电极1，连接到两侧的连通管15a和15b 孔19的表面（即，流路9）彼此相对，连接到连通管15a和15b的电阻槽6a和6b，布置在电阻槽6a和6b中的薄膜电阻器3a和3b，以及 参考电极2连接到端子4b。
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公开(公告)号：US07006929B2
公开(公告)日：2006-02-28
申请号：US10479938
申请日：2002-06-05
IPC分类号： G06F19/00
CPC分类号： G01N33/48728
摘要： A sensor capable of simply and quickly measuring the electrical activities of a number of cells simultaneously and a device comprising the sensor and capable of detecting the signal transmission between subject cells are provided. The sensor comprises a plurality of electrodes provided on a substrate. The electrodes individually measure a signal generated by a biological sample held by each of the electrodes. Each of the electrodes comprises a depression for holding the biological sample, a throughhole which is in communication with the depression and penetrates to a rear side of the substrate, an electrode portion, and a drawing line from the electrode portion. The electrodes are arranged so that the samples held by the depressions electrically communicate with one another.
摘要翻译： 提供了能够简单且快速地同时测量多个单元的电活动的传感器，以及包括该传感器并且能够检测主体单元之间的信号传输的设备。 传感器包括设置在基板上的多个电极。 电极单独地测量由每个电极保持的生物样品产生的信号。 每个电极包括用于保持生物样品的凹陷，与凹陷连通并穿透到基底的后侧的通孔，电极部分和来自电极部分的引出线。 电极被布置成使得由凹陷保持的样品彼此电连通。
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6.再颁专利公开(公告)号：USRE38323E1
公开(公告)日：2003-11-18
申请号：US09169188
申请日：1998-10-08
IPC分类号： C12M134
CPC分类号： G01N33/4836 , C12M41/46
摘要： A cell potential measurement apparatus, which uses a planar electrode enabling a multi-point simultaneous measurement of potential change arising from cell activities, is provided which can conduct measurements accurately and efficiently as well as can improve convenience of arranging measurement results. According to the configuration of the cell potential measurement apparatus of this invention, it includes an integrated cell holding instrument, which includes a planar electrode provided with a plurality of microelectrodes arranged in a matrix form on the surface of a substrate, a cell holding part for placing cells thereon, drawer patterns from the microelectrodes, and electric contact points for outside connections; an optical observation means for optical observations of cells; a stimulation signal supply means to be connected to the cell holding instrument for providing electric stimulation to the cells; and a signal processing means to be connected to the cell holding instrument for processing an output signal arising from electric physiological activities of the cells. It is preferable that a cell culturing means is also provided for maintaining a culture atmosphere of the cells placed on the integrated cell holding instrument.
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公开(公告)号：US20080050765A1
公开(公告)日：2008-02-28
申请号：US11976951
申请日：2007-10-30
申请人： Hidenobu Yaku , Hirokazu Sugihara
发明人： Hidenobu Yaku , Hirokazu Sugihara
CPC分类号： C12Q1/32 , C12N9/0006 , C12N11/18 , C12Q1/003 , C12Y101/01037 , G01N33/54393
摘要： Immobilization of malate dehydrogenase on a substrate using a glycerol solution containing malate dehydrogenase is achieved through dropping a mixed solution obtained by adding at least one selected from malic acid and malate to the glycerol containing malate dehydrogenase on the substrate, and drying it thereon. It is preferable to prepare the mixed solution by adding the malate to the glycerol solution containing malate dehydrogenase. The malate is preferably at least one selected from potassium malate and sodium malate.
摘要翻译： 使用含有苹果酸脱氢酶的甘油溶液将底物上的苹果酸脱氢酶固定在底物上，通过将通过将选自苹果酸和苹果酸中的至少一种的至少一种添加到底物上的甘油含苹果酸脱氢酶中而得到的混合溶液进行干燥。 优选通过将苹果酸盐加入到含有苹果酸脱氢酶的甘油溶液中来制备混合溶液。 苹果酸盐优选为选自苹果酸钾和苹果酸钾中的至少一种。
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8.发明授权公开(公告)号：US07172860B2
公开(公告)日：2007-02-06
申请号：US10678138
申请日：2003-10-06
申请人： Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
发明人： Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
IPC分类号： C12Q1/00
CPC分类号： G01N33/48728 , G01N33/54373 , G01N33/5438
摘要： The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys the target liquid stored in the measurement chamber (A) and passes the target liquid through the porous insulating substrate (5) from the measurement electrode (1) side, wherein the conveying device (8) is operated to trap the biological sample contained in the target liquid onto the measurement electrode (1), so that the activity signals of the biological sample are measured through the measurement electrode (1). According to the apparatus, activity signals emitted from the biological sample can be detected easily, rapidly and accurately.
摘要翻译： 本发明提供了一种用于测量生物样品的活动信号的装置，包括：存储含有生物样品的目标液体的测量室（A） 在至少一侧设置有测量电极（1）的多孔绝缘基板（5） 以及输送装置（8），其输送存储在测量室（A）中的目标液体，并将目标液体通过多孔绝缘基板（5）从测量电极（1）侧移动，其中输送装置（8）为 操作以将包含在目标液体中的生物样品捕获到测量电极（1）上，从而通过测量电极（1）测量生物样品的活性信号。 根据该装置，可以容易，快速且准确地检测从生物样品发射的活动信号。
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公开(公告)号：US06999905B2
公开(公告)日：2006-02-14
申请号：US10296007
申请日：2002-04-26
申请人： Ryuta Ogawa , Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
发明人： Ryuta Ogawa , Hiroaki Oka , Nobuhiko Ozaki , Hirokazu Sugihara
IPC分类号： G06F15/00
CPC分类号： G01D1/14
摘要： A method for extracting a signal of interest from a signal generated from at least one subject, comprises the steps of (A) obtaining a time-series signal generated from the subject as a data group consisting of a plurality of pieces of data, (B) obtaining a plurality of extracted data groups from the data group, wherein each extracted data group comprises a predetermined number of pieces of data selected from the data group, (C) calculating standard deviations of the plurality of extracted data groups to obtain a standard deviation group, and (D) referencing each standard deviation included in the standard deviation group and selecting the signal of interest.
摘要翻译： 一种用于从至少一个对象产生的信号中提取感兴趣的信号的方法，包括以下步骤：（A）获得从被摄体产生的时间序列信号作为由多条数据组成的数据组（B ）从所述数据组中获取多个提取的数据组，其中每个提取的数据组包括从所述数据组中选择的预定数量的数据，（C）计算所述多个提取的数据组的标准偏差以获得标准偏差 组和（D）参考包括在标准偏差组中的每个标准偏差并选择感兴趣的信号。
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10.发明申请Measurement device for measuring electric signal emitted by biological sample 有权用于测量生物样品发出的电信号的测量装置公开(公告)号：US20050004442A1
公开(公告)日：2005-01-06
申请号：US10495621
申请日：2002-11-19
申请人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
发明人： Nobuhiko Ozaki , Hiroaki Oka , Hirokazu Sugihara
IPC分类号： B01L3/00 , G01N33/487 , A61B5/05
CPC分类号： G01N33/48707 , B01L3/5027
摘要： A measurement device 10 includes a measurement cell 11. The measurement cell 11 includes a substrates 17 and a substrate 16 formed on the substrate 17. The substrates 16 and 17 are bonded to each other. Thus, a flow pass 9 is formed in the measurement cell 11. As shown in FIG. 3, on the substrate 17 of the measurement cell 11, provided are a concave well 19, a protruding microelectrode 1 connected to a terminal 4a and formed on a side wall surface of the well 19, communicating tubes 15a and 15b connected to both of side surfaces of the well 19 (i.e., the flow pass 9) to face to each other, resistance baths 6a and 6b connected to the communicating tubes 15a and 15b, thin film resistors 3a and 3b arranged in the resistance baths 6a and 6b, and a reference electrode 2 connected to a terminal 4b.
摘要翻译： 测量装置10包括测量单元11.测量单元11包括基板17和形成在基板17上的基板16.基板16和17彼此接合。 因此，在测量单元11中形成流路9。 如图3所示，在测量单元11的基板17上设置凹槽19，连接到端子4a并形成在井19的侧壁表面上的突出微电极1，连接到两侧的连通管15a和15b 孔19的表面（即，流路9）彼此相对，连接到连通管15a和15b的电阻槽6a和6b，布置在电阻槽6a和6b中的薄膜电阻器3a和3b，以及 参考电极2连接到端子4b。
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