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公开(公告)号:US20240091536A1
公开(公告)日:2024-03-21
申请号:US18488125
申请日:2023-10-17
申请人: Scion Neurostim Inc.
发明人: Robert D. Black , Lanty L. Smith , Lesco L. Rogers
CPC分类号: A61N1/36036 , A61N1/0456 , A61N1/36025 , A61N1/36031 , A61N2/002 , A61N2/006
摘要: Systems, devices, and methods for neurostimulation via vestibular stimulation are described. One example is a device for administering thermal stimulation to an ear canal of a subject. The device may include an earpiece configured to be at least partially insertable into the ear canal of the subject; a thermoelectric device thermally coupled to the earpiece and configured to heat and/or cool the earpiece to thereby heat and/or cool the ear canal of the subject; and a controller configured to administer a selected treatment plan including administering a caloric vestibular stimulation (CVS) stimulus to the ear canal of the subject in a condition-treatment effective amount during a first treatment interval. The treatment plan may be effective to produce a durable improvement in at least one symptom of the condition for a time of at least 1 week following cessation of the administering.
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公开(公告)号:US11510808B2
公开(公告)日:2022-11-29
申请号:US16883007
申请日:2020-05-26
发明人: Lanty L. Smith , Leseo L. Rogers , Robert D. Black
摘要: An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.
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公开(公告)号:US11794010B2
公开(公告)日:2023-10-24
申请号:US16978482
申请日:2019-03-06
发明人: Robert D. Black , Lanty L. Smith , Leseo L. Rogers
CPC分类号: A61N1/36036 , A61N1/0456 , A61N1/36025 , A61N1/36031 , A61N2/002 , A61N2/006
摘要: Systems, devices, and methods for neurostimulation via vestibular stimulation are described. One example is a device for administering thermal stimulation to an ear canal of a subject. The device may include an earpiece configured to be at least partially insertable into the ear canal of the subject; a thermoelectric device thermally coupled to the earpiece and configured to heat and/or cool the earpiece to thereby heat and/or cool the ear canal of the subject; and a controller configured to administer a selected treatment plan including administering a caloric vestibular stimulation (CVS) stimulus to the ear canal of the subject in a condition-treatment effective amount during a first treatment interval. The treatment plan may be effective to produce a durable improvement in at least one symptom of the condition for a time of at least 1 week following cessation of the administering.
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公开(公告)号:US20240131332A1
公开(公告)日:2024-04-25
申请号:US18488111
申请日:2023-10-16
申请人: Scion Neurostim Inc.
发明人: Robert D. Black , Lanty L. Smith , Lesco L. Rogers
CPC分类号: A61N1/36036 , A61N1/0456 , A61N1/36025 , A61N1/36031 , A61N2/002 , A61N2/006
摘要: Systems, devices, and methods for neurostimulation via vestibular stimulation are described. One example is a device for administering thermal stimulation to an ear canal of a subject. The device may include an earpiece configured to be at least partially insertable into the ear canal of the subject; a thermoelectric device thermally coupled to the earpiece and configured to heat and/or cool the earpiece to thereby heat and/or cool the ear canal of the subject; and a controller configured to administer a selected treatment plan including administering a caloric vestibular stimulation (CVS) stimulus to the ear canal of the subject in a condition-treatment effective amount during a first treatment interval. The treatment plan may be effective to produce a durable improvement in at least one symptom of the condition for a time of at least 1 week following cessation of the administering.
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公开(公告)号:US11583439B2
公开(公告)日:2023-02-21
申请号:US17171354
申请日:2021-02-09
发明人: Robert D. Black , Lanty L. Smith , Leseo L. Rogers
IPC分类号: A61N1/04 , A61N1/36 , A61N1/05 , A61F7/12 , A61B6/03 , A61F7/00 , A61M21/02 , H04R1/10 , A61M21/00 , A61N1/32
摘要: A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include an amplitude and a carrier frequency. The method may include modulating the electrical signal based on an audio waveform. In some embodiments, the modulating may include modulating at least one of the amplitude and the carrier frequency based on the audio waveform to modulate the electrical signal.
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公开(公告)号:US20240226553A9
公开(公告)日:2024-07-11
申请号:US18488111
申请日:2023-10-17
申请人: Scion Neurostim Inc.
发明人: Robert D. Black , Lanty L. Smith , Lesco L. Rogers
CPC分类号: A61N1/36036 , A61N1/0456 , A61N1/36025 , A61N1/36031 , A61N2/002 , A61N2/006
摘要: Systems, devices, and methods for neurostimulation via vestibular stimulation are described. One example is a device for administering thermal stimulation to an ear canal of a subject. The device may include an earpiece configured to be at least partially insertable into the ear canal of the subject; a thermoelectric device thermally coupled to the earpiece and configured to heat and/or cool the earpiece to thereby heat and/or cool the ear canal of the subject; and a controller configured to administer a selected treatment plan including administering a caloric vestibular stimulation (CVS) stimulus to the ear canal of the subject in a condition-treatment effective amount during a first treatment interval. The treatment plan may be effective to produce a durable improvement in at least one symptom of the condition for a time of at least 1 week following cessation of the administering.
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7.
公开(公告)号:US11865037B2
公开(公告)日:2024-01-09
申请号:US17171285
申请日:2021-02-09
发明人: Robert D. Black , Lanty L. Smith , Lesco L. Rogers
IPC分类号: A61N1/04 , A61N1/36 , A61M21/02 , A61F7/12 , A61B6/03 , A61N1/05 , A61F7/00 , H04R1/10 , A61M21/00 , A61N1/32
CPC分类号: A61F7/12 , A61B6/037 , A61F7/007 , A61M21/02 , A61N1/0456 , A61N1/0484 , A61N1/0526 , A61N1/36021 , A61N1/36025 , A61N1/36028 , A61N1/36031 , A61N1/36034 , H04R1/1016 , H04R1/1091 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/126 , A61M2021/0027 , A61M2021/0072 , A61M2021/0077 , A61M2205/054 , A61M2210/0662 , A61N1/327 , H04R1/10 , H04R2460/13
摘要: A method of galvanic vestibular stimulation (GVS) may include delivering an electrical signal via transdermal electrical stimulation using a plurality of electrodes connected to a patient. The electrical signal may include an amplitude and a carrier frequency. The method may include modulating at least one of the amplitude and the carrier frequency based on a modulation waveform to modulate the electrical signal, the modulation waveform may include a modulation frequency that is less than the carrier frequency.
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公开(公告)号:US11701253B2
公开(公告)日:2023-07-18
申请号:US17315542
申请日:2021-05-10
发明人: Robert D. Black , Lanty L. Smith , Lesco L. Rogers
IPC分类号: A61F7/12 , A61N1/04 , A61N1/36 , A61B6/03 , A61N1/05 , A61F7/00 , A61M21/02 , H04R1/10 , A61M21/00 , A61N1/32
CPC分类号: A61F7/12 , A61B6/037 , A61F7/007 , A61M21/02 , A61N1/0456 , A61N1/0484 , A61N1/0526 , A61N1/36021 , A61N1/36025 , A61N1/36028 , A61N1/36031 , A61N1/36034 , H04R1/1016 , H04R1/1091 , A61F2007/0005 , A61F2007/0075 , A61F2007/0093 , A61F2007/126 , A61M2021/0027 , A61M2021/0072 , A61M2021/0077 , A61M2205/054 , A61M2210/0662 , A61N1/327 , H04R1/10 , H04R2460/13
摘要: A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.
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