公开(公告)号：US10980666B2

公开(公告)日：2021-04-20

申请号：US16004790

申请日：2018-06-11

申请人： Scion NeuroStim, LLC

发明人： Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61B18/18 ,  A61F7/12 ,  A61F7/00

摘要： An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.

公开(公告)号：US10918518B2

公开(公告)日：2021-02-16

申请号：US15757200

申请日：2016-09-01

申请人： Scion Neurostim, LLC

发明人： Robert D. Black ,  Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61N1/04 ,  A61N1/36 ,  A61N1/05 ,  A61F7/12 ,  A61B6/03 ,  A61F7/00 ,  A61M21/02 ,  H04R1/10 ,  A61M21/00 ,  A61N1/32

摘要： A method of neurostimulation includes delivering an electrical signal to a plurality of electrodes (215A, 215B) connected to a patient. The electrical signal is characterized by an amplitude and a carrier frequency. The method includes modulating an electrical signal based on an audio waveform. In some cases, the modulation may include modulating at least one of an amplitude and a carrier frequency based on the audio waveform. A neurostimulation device (200) comprising first and second electrodes is also disclosed.

公开(公告)号：US20180193641A1

公开(公告)日：2018-07-12

申请号：US15914516

申请日：2018-03-07

申请人： Scion Neurostim, LLC

发明人： Robert D. Black ,  Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61N1/36 ,  A61F7/12 ,  A61N1/05 ,  A61B6/03

CPC分类号： A61N1/36036 ,  A61B6/037 ,  A61F7/007 ,  A61F7/12 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/126 ,  A61M21/02 ,  A61M35/00 ,  A61M2021/0027 ,  A61M2021/0072 ,  A61M2021/0077 ,  A61M2205/054 ,  A61M2210/0662 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0526 ,  A61N1/327 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36028 ,  A61N1/36031 ,  A61N1/36034 ,  H04R1/10 ,  H04R1/1016 ,  H04R1/1091 ,  H04R2460/13

摘要： A method of neurostimulation may include delivering a modulated electrical signal to a patient through galvanic vestibular stimulation (GVS) and delivering a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) simultaneous with the delivery of the modulated electrical signal through GVS.

公开(公告)号：US20140309718A1

公开(公告)日：2014-10-16

申请号：US14099059

申请日：2013-12-06

申请人： Scion NeuroStim, LLC

发明人： Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61F7/007 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/0096

摘要： An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.

公开(公告)号：US20210137730A1

公开(公告)日：2021-05-13

申请号：US16883007

申请日：2020-05-26

申请人： Scion NeuroStim, LLC

发明人： Lanty L. Smith ,  Lesco L. Rogers ,  Robert D. Black

IPC分类号： A61F7/12 ,  A61N2/00 ,  A61F7/00

摘要： An in-ear stimulation device for administering caloric stimulation to the ear canal of a subject includes (a) first and second earpieces configured to be insertable into the ear canals of the subject; (b) at least first and second thermoelectric devices thermally coupled to respective ones of the first and second earpieces; (c) a first heat sink thermally coupled to the first thermoelectric device opposite the first earpiece and a second heat sink thermally coupled to the second thermoelectric device opposite the second earpiece; and (d) a controller comprising a waveform generator in communication with the first and second thermoelectric devices, the waveform generator configured to generate a first control signal to control a first caloric output to the first thermoelectric device and a second control signal to control a second caloric output to the second caloric device.

公开(公告)号：US10478331B2

公开(公告)日：2019-11-19

申请号：US15379612

申请日：2016-12-15

申请人： Scion Neurostim, LLC

发明人： Lesco L. Rogers ,  Lanty L. Smith ,  Robert D. Black

IPC分类号： A61B18/18 ,  A61F7/00 ,  A61F7/12 ,  A61F7/02

摘要： The present invention provides devices, systems and methods for delivering one or more thermal waveforms to the vestibular system and/or the nervous system of a patient. In some embodiments, the present invention provides a vestibular stimulation device configured both to generate a prescription for delivering one or more thermal waveforms and to deliver the prescribed thermal waveforms.

公开(公告)号：US20180289960A1

公开(公告)日：2018-10-11

申请号：US15757200

申请日：2016-09-01

申请人： Scion Neurostim, LLC

发明人： Robert D. Black ,  Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61N1/36 ,  A61M21/02 ,  A61N1/04 ,  H04R1/10

摘要： A method of neurostimulation includes delivering an electrical signal to a plurality of electrodes (215A, 215B) connected to a patient. The electrical signal is characterized by an amplitude and a carrier frequency. The method includes modulating an electrical signal based on an audio waveform. In some cases, the modulation may include modulating at least one of an amplitude and a carrier frequency based on the audio waveform. A neurostimulation device (200) comprising first and second electrodes is also disclosed.

公开(公告)号：US20180264265A1

公开(公告)日：2018-09-20

申请号：US15757098

申请日：2016-09-01

申请人： Scion Neurostim, LLC

发明人： Robert D. Black ,  Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61N1/36 ,  A61M21/02 ,  A61N1/04 ,  A61F7/00 ,  H04R1/10

CPC分类号： A61N1/36036 ,  A61B6/037 ,  A61F7/007 ,  A61F7/12 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/126 ,  A61M21/02 ,  A61M35/00 ,  A61M2021/0027 ,  A61M2021/0072 ,  A61M2021/0077 ,  A61M2205/054 ,  A61M2210/0662 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0526 ,  A61N1/327 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36028 ,  A61N1/36031 ,  A61N1/36034 ,  H04R1/10 ,  H04R1/1016 ,  H04R1/1091 ,  H04R2460/13

摘要： A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include a plurality of spaced-apart packets of electrical pulses. The method may include modulating at least one of a quantity of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a width in time of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, an amplitude in voltage of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a separation in time between adjacent ones of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, and a separation in time between adjacent ones of the plurality of packets of electrical pulses to modulate the electrical signal.

公开(公告)号：US20180250511A1

公开(公告)日：2018-09-06

申请号：US15757140

申请日：2016-09-01

申请人： Scion Neurostim, LLC

发明人： Robert D. Black ,  Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61N1/36 ,  A61N1/04 ,  A61M21/02 ,  A61F7/00

CPC分类号： A61N1/36036 ,  A61B6/037 ,  A61F7/007 ,  A61F7/12 ,  A61F2007/0005 ,  A61F2007/0075 ,  A61F2007/0093 ,  A61F2007/126 ,  A61M21/02 ,  A61M35/00 ,  A61M2021/0027 ,  A61M2021/0072 ,  A61M2021/0077 ,  A61M2205/054 ,  A61M2210/0662 ,  A61N1/0456 ,  A61N1/0484 ,  A61N1/0526 ,  A61N1/327 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36028 ,  A61N1/36031 ,  A61N1/36034 ,  H04R1/10 ,  H04R1/1016 ,  H04R1/1091 ,  H04R2460/13

摘要： A method of galvanic vestibular stimulation (GVS) may include delivering an electrical signal via transdermal electrical stimulation using a plurality of electrodes connected to a patient. The electrical signal may include an amplitude and a carrier frequency. The method may include modulating at least one of the amplitude and the carrier frequency based on a modulation waveform to modulate the electrical signal, the modulation waveform may include a modulation frequency that is less than the carrier frequency.

公开(公告)号：US20210259879A1

公开(公告)日：2021-08-26

申请号：US17315542

申请日：2021-05-10

申请人： Scion Neurostim, LLC

发明人： Robert D. Black ,  Lanty L. Smith ,  Lesco L. Rogers

IPC分类号： A61F7/12 ,  A61N1/04 ,  A61N1/36 ,  A61B6/03 ,  A61N1/05 ,  A61F7/00 ,  A61M21/02 ,  H04R1/10

摘要： A vestibular neurostimulation device, which may include first and second electrodes; first and second thermoelectric devices thermally coupled, respectively, to first and second earpieces that are configured to be insertable into respective ear canals of a patient; and a controller comprising a waveform generator. The waveform generator may be is configured to deliver a modulated electric signal to the patient through galvanic vestibular stimulation (GVS) using the first and second electrodes and to deliver a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) using the first and second earpieces simultaneous with the delivery of the modulated electrical signal through GVS. The CVS and/or GVS may be configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.