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11 条记录 (耗时 0.035 秒)

    Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers
    1.
    发明申请
    Substituted Benzodiazepinones, Benzoxazepinones and Benzothiazepinones as Sodium Channel Blockers 审中-公开
    取代苯并二氮杂酮，苯并西泮酮和苯并硫氮酮作为钠通道阻断剂

    公开(公告)号：US20100144715A1

    公开(公告)日：2010-06-10

    申请号：US12528041

    申请日：2008-02-25

    申请人： Scott B. Hoyt ,  Dong Ok ,  Hyun Ok ,  Clare London ,  Joseph I. Duffy

    发明人： Scott B. Hoyt ,  Dong Ok ,  Hyun Ok ,  Clare London ,  Joseph I. Duffy

    IPC分类号： A61K31/551 ,  C07D243/12 ,  C07D281/08 ,  A61K31/553 ,  A61K31/554 ,  A61P25/08

    CPC分类号： C07D281/10 ,  C07D245/06 ,  C07D267/14

    摘要： The present invention is directed to substituted benzodiazepinones, benzoxazepinones and benzothiazepinones compounds that are sodium channel blockers useful for the treatment of chronic and neuropathic pain. The compounds of the present invention are also useful for the treatment of other conditions, including disorders of the CNS such as anxiety, depression, epilepsy, manic depression and bipolar disorder. This invention also provides pharmaceutical compositions comprising a compound of the present invention, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. This invention further comprises methods for the treatment of acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain and disorders of the CNS including, but not limited to, epilepsy, manic depression, depression, anxiety and bipolar disorder comprising administering the compounds and pharmaceutical compositions of the present invention.

    摘要翻译： 本发明涉及用作治疗慢性和神经性疼痛的钠通道阻滞剂的取代苯并二氮杂酮，苯并氧氮杂酮和苯并噻唑酮化合物。 本发明的化合物还可用于治疗其他病症，包括CNS的疾病如焦虑症，抑郁症，癫痫症，躁狂抑郁症和双相性精神障碍。 本发明还提供包含单独的或与一种或多种治疗活性化合物组合的本发明化合物和药学上可接受的载体的药物组合物。 本发明还包括用于治疗急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛和中枢神经系统疾病的方法，包括但不限于癫痫症，躁狂抑郁症，抑郁症，焦虑症和双相性躁动症，包括给予化合物 和本发明的药物组合物。

    Substituted Triazoles as Sodium Channel Blockers
    7.
    发明申请
    Substituted Triazoles as Sodium Channel Blockers 审中-公开
    取代三唑作为钠通道阻断剂

    公开(公告)号：US20090074890A1

    公开(公告)日：2009-03-19

    申请号：US10578950

    申请日：2004-11-05

    申请人： Min K. Park ,  Prasun K. Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William H. Parsons ,  Rosemary Sisco ,  Michael H. Fisher ,  Louis L. Zuegner, III

    发明人： Min K. Park ,  Prasun K. Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William H. Parsons ,  Rosemary Sisco ,  Michael H. Fisher ,  Louis L. Zuegner, III

    IPC分类号： C07D249/08 ,  A61P29/00 ,  A61P9/00 ,  A61P25/00 ,  A61K33/00 ,  A61K31/4196 ,  A61P1/00 ,  A61P31/12 ,  A61P37/00

    CPC分类号： C07D249/10 ,  C07D403/10

    摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier (I), (II), (III).

    摘要翻译： 由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病 神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体（I），（II），（III） 。

    Substituted triazoles as sodium channel blockers
    8.
    发明申请
    Substituted triazoles as sodium channel blockers 有权
    取代的三唑作为钠通道阻断剂

    公开(公告)号：US20060020006A1

    公开(公告)日：2006-01-26

    申请号：US10985592

    申请日：2004-11-10

    申请人： Min Park ,  Prasun Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William Parsons ,  Rosemary Sisco ,  Michael Fisher ,  Louis Zuegner

    发明人： Min Park ,  Prasun Chakravarty ,  Bishan Zhou ,  Edward Gonzalez ,  Hyun Ok ,  Brenda Palucki ,  William Parsons ,  Rosemary Sisco ,  Michael Fisher ,  Louis Zuegner

    IPC分类号： A61K31/4196 ,  C07D403/02

    CPC分类号： C07D249/10 ,  C07D403/10

    摘要： Substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, migraine, headache pain, migraine headache, epilepsy, irritable bowel syndrome, diabetic neuropathy, multiple sclerosis, manic depression and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

    摘要翻译： 由式I，II或III表示的取代的三唑化合物或其药学上可接受的盐。 药物组合物包含单独的或与一种或多种其它治疗活性化合物组合的有效量的本发明化合物和药学上可接受的载体。 治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛，偏头痛，头痛，偏头痛，癫痫，肠易激综合征，糖尿病 神经病，多发性硬化症，躁狂抑郁症和双相性精神障碍，包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物组合施用。 施用局部麻醉的方法包括单独施用有效量的本发明化合物或与一种或多种其它治疗活性化合物和药学上可接受的载体组合施用。