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公开(公告)号：US06326153B2
公开(公告)日：2001-12-04
申请号：US09784943
申请日：2001-02-14
IPC分类号： C12Q168
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure are disclosed, including nitrogen and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有结构的二苄唑胺化合物，包括其氮和芳基取代形式。 此外，公开了可用于合成这些化合物的两个中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有包括其氮和芳基取代形式的结构的第二中间体，其中位置C- 14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US20110124510A1
公开(公告)日：2011-05-26
申请号：US12899508
申请日：2010-10-06
IPC分类号： C40B30/00
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄氧苯胺类化合物，包括其氮和芳基取代的形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有其氮和芳基取代形式的结构的第二中间体，其中位置 C-14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US06221606B1
公开(公告)日：2001-04-24
申请号：US09556040
申请日：2000-04-20
IPC分类号： C12Q168
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forns thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alky, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 具有该结构的二苄唑胺化合物，包括硝基和芳基取代的形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括氮和芳基取代的其中的结构的第一中间体和具有包括其氮和芳基取代形式的结构的第二中间体，其中位置C- 14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US06919445B2
公开(公告)日：2005-07-19
申请号：US10441950
申请日：2003-05-20
IPC分类号： G01N21/78 , C07C215/86 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/02 , C09B11/24 , C09B11/28 , C09K11/06 , C12N15/09 , C12Q1/68 , C09B69/00
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄氧苯胺类化合物，包括其氮和芳基取代的形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有其氮和芳基取代形式的结构的第二中间体，其中位置 C-14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团和取代的 形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US07833756B2
公开(公告)日：2010-11-16
申请号：US12169624
申请日：2008-07-08
IPC分类号： C07D487/00 , C07H21/00
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄氧苯胺类化合物，包括其氮和芳基取代的形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有其氮和芳基取代形式的结构的第二中间体，其中位置 C-14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US06566071B2
公开(公告)日：2003-05-20
申请号：US09969430
申请日：2001-10-02
IPC分类号： C12Q168
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure: are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure: including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有以下结构的二苄唑胺化合物：包括其氮和芳基取代的形式。 此外，公开了可用于合成这些化合物的两个中间体，具有以下结构的第一中间体：包括其氮和芳基取代的形式，以及具有包括其氮和芳基取代形式的结构的第二中间体， C14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US6111116A
公开(公告)日：2000-08-29
申请号：US199402
申请日：1998-11-24
IPC分类号： G01N21/78 , C07C215/86 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/02 , C09B11/24 , C09B11/28 , C09K11/06 , C12N15/09 , C12Q1/68
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333
摘要： Dibenzorhodamine compounds having the structure ##STR1## are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure ##STR2## including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure ##STR3## including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, --CH.sub.2 OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodarnine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄唑胺化合物，包括硝基和芳基取代形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有其氮和芳基取代形式的结构的第二中间体，其中位置 C-14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并胍基化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US5936087A
公开(公告)日：1999-08-10
申请号：US978775
申请日：1997-11-25
IPC分类号： G01N21/78 , C07C215/86 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/02 , C09B11/24 , C09B11/28 , C09K11/06 , C12N15/09 , C12Q1/68 , C07D221/18
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333
摘要： Dibenzorhodamine compounds having the structure ##STR1## are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure ##STR2## including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure ##STR3## including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, --CH.sub.2 OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄唑胺化合物，包括硝基和芳基取代形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有其氮和芳基取代形式的结构的第二中间体，其中位置 C-14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US6051719A
公开(公告)日：2000-04-18
申请号：US193374
申请日：1998-11-17
申请人： Scott Conrad Benson , Joe Y. L. Lam , Krishna Gajanan Upadhya , Peggy Ann Radel , Weiguo Zhen , Steven Michael Menchen
发明人： Scott Conrad Benson , Joe Y. L. Lam , Krishna Gajanan Upadhya , Peggy Ann Radel , Weiguo Zhen , Steven Michael Menchen
IPC分类号： G01N21/78 , C07C215/86 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/06 , C07H19/10 , C07H19/14 , C07H19/16 , C07H19/20 , C07H21/00 , C09B11/02 , C09B11/24 , C09B11/28 , C09K11/06 , C12N15/09 , C12Q1/68 , C07D221/18
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333
摘要： Dibenzorhodamine compounds having the structure ##STR1## are disclosed, including nitogen- and aryl-substituted forms thereof. In addition, intermediates useful for synthesizing such compounds are disclosed, such intermediates having the structure ##STR2## In Formula I, R.sub.1 is H or ##STR3## wherein Y is H, lower alkyl, lower alkene, lower alkyne, aromatic, phenyl, polycyclic aromatic, heterocycle, water-solubilizing group, or linking group, including substituted forms thereof. When R.sub.1 is H, the C-12-bonded nitrogen and the C-12 and C-13 carbons form a first ring structure having from 4 to 7 members, and/or the C-12-bonded nitrogen and the C-11 and C-12 carbons form a second ring structure having from 5 to 7 members. The compounds of Formula I further include aryl- and nitrogen-substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄唑胺化合物，包括硝基和芳基取代形式。 此外，公开了可用于合成这些化合物的中间体，具有结构式I，R1为H或其中Y为H，低级烷基，低级烯，低级炔，芳香族，苯基，多环芳族，杂环， 增溶基团或连接基团，包括其取代形式。 当R1为H时，C-12键合的氮和C-12和C-13碳形成具有4至7个成员的第一环结构和/或C-12键合的氮和C-11和 C-12碳形成具有5至7个成员的第二环结构。 式I的化合物还包括其芳基和氮取代的形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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公开(公告)号：US20090068751A1
公开(公告)日：2009-03-12
申请号：US12169624
申请日：2008-07-08
IPC分类号： G01N33/48 , C07D311/78 , C07D221/18 , C07D487/12 , C07C211/43 , C07D209/56 , C07D221/06 , C07H19/06 , C07H19/16
CPC分类号： C09B11/24 , C07D209/60 , C07D221/10 , C07D311/78 , C07D491/14 , C07D491/147 , C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/02 , C12Q1/6869 , Y10T436/143333 , C12Q2563/107 , C12Q2527/125
摘要： Dibenzorhodamine compounds having the structure are disclosed, including nitrogen- and aryl-substituted forms thereof. In addition, two intermediates useful for synthesizing such compounds are disclosed, a first intermediate having the structure including nitrogen- and aryl-substituted forms thereof, and a second intermediate having the structure including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C-14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine compounds, nucleosides labeled with the dibenzorhodamine compounds, and nucleic acid analysis methods employing the dibenzorhodamine compounds.
摘要翻译： 公开了具有该结构的二苄氧苯胺类化合物，包括其氮和芳基取代的形式。 此外，公开了可用于合成这些化合物的两种中间体，具有包括其氮和芳基取代形式的结构的第一中间体和具有其氮和芳基取代形式的结构的第二中间体，其中位置 C-14至C18分别选自氢，氯，氟，低级烷基，羧酸，磺酸，-CH 2 OH，烷氧基，苯氧基，连接基团及其取代形式。 本发明还包括包含二苄基罗丹胺化合物的能量转移染料，用二苯并呋喃胺化合物标记的核苷，以及使用二苯并呋喃胺化合物的核酸分析方法。
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