公开(公告)号：US20110263639A1

公开(公告)日：2011-10-27

申请号：US13091772

申请日：2011-04-21

申请人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alejandro Santillán, JR.

发明人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alejandro Santillán, JR.

IPC分类号： A61K31/46 ,  C12N9/99 ,  A61P29/00 ,  C07D451/04

CPC分类号： C07D487/08 ,  C07D417/12 ,  C07D451/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法 ，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。

公开(公告)号：US08367719B2

公开(公告)日：2013-02-05

申请号：US13091772

申请日：2011-04-21

申请人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alejandro Santillán, Jr.

发明人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alejandro Santillán, Jr.

IPC分类号： A61K31/34

CPC分类号： C07D487/08 ,  C07D417/12 ,  C07D451/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

公开(公告)号：US07935725B2

公开(公告)日：2011-05-03

申请号：US12291018

申请日：2008-10-30

申请人： Scott D. Bembenek ,  Wendy Eccles ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Taraneh Mirzadegan ,  Alejandro Santillán, Jr.

发明人： Scott D. Bembenek ,  Wendy Eccles ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Taraneh Mirzadegan ,  Alejandro Santillán, Jr.

IPC分类号： A61K31/38

CPC分类号： C07D487/08 ,  C07D417/12 ,  C07D451/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

公开(公告)号：US20090111794A1

公开(公告)日：2009-04-30

申请号：US12291018

申请日：2008-10-30

申请人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alejandro Santillan, JR.

发明人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alejandro Santillan, JR.

IPC分类号： A61K31/55 ,  C07D277/68 ,  C07D263/54 ,  C07D487/08 ,  A61K31/423 ,  A61K31/4439 ,  A61P37/02 ,  A61K31/497 ,  A61K31/428 ,  C07D401/14 ,  C07D417/14

CPC分类号： C07D487/08 ,  C07D417/12 ,  C07D451/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法 ，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。

公开(公告)号：US20110257153A1

公开(公告)日：2011-10-20

申请号：US13091498

申请日：2011-04-21

申请人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. Mcclure ,  Taraneh Mirzadegan ,  Alexandro Santillan, JR.

发明人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. Mcclure ,  Taraneh Mirzadegan ,  Alexandro Santillan, JR.

IPC分类号： A61K31/428 ,  C12N9/99 ,  C07D451/02 ,  A61K31/46 ,  A61K31/4995 ,  C07D487/04 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/5377 ,  A61P29/00 ,  A61P17/00 ,  A61P11/06 ,  A61P1/00 ,  A61P9/10 ,  A61P17/02 ,  C07D487/08

CPC分类号： C07D487/08 ,  C07D417/12 ,  C07D451/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

公开(公告)号：US08344008B2

公开(公告)日：2013-01-01

申请号：US13091498

申请日：2011-04-21

申请人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alexandro Santillán, Jr.

发明人： Genesis M. Bacani ,  Scott D. Bembenek ,  Wendy Eccles ,  James P. Edwards ,  Matthew T. Epperson ,  Laurent Gomez ,  Cheryl A. Grice ,  Aaron M. Kearney ,  Adrienne M. Landry-Bayle ,  Alice Lee-Dutra ,  Kelly J. McClure ,  Taraneh Mirzadegan ,  Alexandro Santillán, Jr.

IPC分类号： A61K31/425

CPC分类号： C07D487/08 ,  C07D417/12 ,  C07D451/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04

摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法 ，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。

公开(公告)号：US07071177B2

公开(公告)日：2006-07-04

申请号：US09844061

申请日：2001-04-26

申请人： Nancy Elisabeth Krauss ,  Taraneh Mirzadegan ,  David Bernard Smith ,  Keith Adrian Walker

发明人： Nancy Elisabeth Krauss ,  Taraneh Mirzadegan ,  David Bernard Smith ,  Keith Adrian Walker

IPC分类号： A01N51/00 ,  A61K31/63 ,  C07D251/00

CPC分类号： C07D207/27 ,  C07C317/36 ,  C07C323/36 ,  C07D207/14 ,  C07D213/38 ,  C07D213/64 ,  C07D213/74 ,  C07D231/12 ,  C07D233/56 ,  C07D237/12 ,  C07D237/14 ,  C07D249/08 ,  C07D277/28 ,  C07D277/64 ,  C07D333/20

摘要： This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

摘要翻译： 本发明涉及抗炎和止痛化合物，特别是涉及某些对 - （磺酰基）苯基氨基衍生物，含有它们的药物组合物，其使用方法和制备这些化合物的方法。

公开(公告)号：US20070088053A1

公开(公告)日：2007-04-19

申请号：US11583346

申请日：2006-10-18

申请人： Taraneh Mirzadegan ,  Tania Silva

发明人： Taraneh Mirzadegan ,  Tania Silva

IPC分类号： A61K31/445 ,  A61K31/44 ,  A61K31/40 ,  A61K31/277 ,  A61K31/165 ,  A61K31/198

CPC分类号： C07C311/46 ,  C07C235/56 ,  C07C255/58 ,  C07C311/24 ,  C07C311/35 ,  C07C323/52 ,  C07D295/26

摘要： The present invention provides for compounds useful for treating an HIV-1 infection, or preventing an HIV-1 infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1-R4 and Ar are as herein defined. Also disclosed in the present invention are methods of treating an HIV-1 infection with compounds defined herein and pharmaceutical compositions containing said compounds.

摘要翻译： 本发明提供了可用于治疗HIV-1感染或预防HIV-1感染或治疗AIDS或ARC的化合物。 本发明的化合物是式I的化合物，其中R 1 -R 4和Ar如本文所定义。 本发明还公开了用本文定义的化合物治疗HIV-1感染的方法和含有所述化合物的药物组合物。

公开(公告)号：US06747053B2

公开(公告)日：2004-06-08

申请号：US10308963

申请日：2002-12-03

申请人： Tobias Gabriel ,  Nancy Elisabeth Krauss ,  Taraneh Mirzadegan ,  Wylie Solang Palmer ,  David Bernard Smith

发明人： Tobias Gabriel ,  Nancy Elisabeth Krauss ,  Taraneh Mirzadegan ,  Wylie Solang Palmer ,  David Bernard Smith

IPC分类号： A61K31404

CPC分类号： C07D405/12 ,  C07D209/08 ,  C07D209/42 ,  C07D213/81 ,  C07D215/40 ,  C07D215/48 ,  C07D215/54 ,  C07D215/60 ,  C07D217/02 ,  C07D231/38 ,  C07D231/56 ,  C07D241/44 ,  C07D277/62 ,  C07D401/12 ,  C07D409/12 ,  C07D471/04 ,  C07D513/04

摘要： The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5 and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment of diseases which are associated with cysteine proteases such as osteoporosis, osteoarthritis, rheumatoid arthritis, tumor metastasis, glomerulonephritis, atherosclerosis, myocardial infarction, angina pectoris, instable angina pectoris, stroke, plaque rupture, transient ischemic attacks, amaurosis fugax, peripheral arterial occlusive disease, restenosis after angioplasty and stent placement, abdominal aortic aneurysm formation, inflammation, autoimmune disease, malaria, ocular fundus tissue cytopathy and respiratory disease.

摘要翻译： 本发明涉及其中R 1，R 2，R 3，R 4，R 5和n如说明书和权利要求中所定义的式（I）化合物及其药学上可接受的盐 和/或其药学上可接受的酯。 该化合物可用于治疗与半胱氨酸蛋白酶如骨质疏松症，骨关节炎，类风湿性关节炎，肿瘤转移，肾小球性肾炎，动脉粥样硬化，心肌梗死，心绞痛，不稳定性心绞痛，中风，斑块破裂，短暂性脑缺血发作， 外周动脉闭塞性疾病，血管成形术和支架置入后再狭窄，腹主动脉瘤形成，炎症，自身免疫性疾病，疟疾，眼底组织细胞病变和呼吸系统疾病。

公开(公告)号：US07189718B2

公开(公告)日：2007-03-13

申请号：US10807993

申请日：2004-03-23

申请人： James Patrick Dunn ,  Brian William Dymock ,  Taraneh Mirzadegan ,  Eric Brian Sjogren ,  Steven Swallow ,  Zachary Kevin Sweeney

发明人： James Patrick Dunn ,  Brian William Dymock ,  Taraneh Mirzadegan ,  Eric Brian Sjogren ,  Steven Swallow ,  Zachary Kevin Sweeney

IPC分类号： C07D237/14 ,  C07D237/22 ,  A61K31/501

CPC分类号： C07D401/12 ,  C07D237/14 ,  C07D237/22 ,  C07D405/06 ,  C07D409/06

摘要： This invention relates to novel pyridazinone derivatives of formula I wherein R1–R4, R7, R8 and X1 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I, pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula I. The compounds are useful for treating disorders in which HIV and genetically related viruses are implicated

摘要翻译： 本发明涉及式I的新的哒嗪酮衍生物，其中R 1，R 2，R 4，R 7，R 8， 和其中X 1如本发明概述及其药学上可接受的盐和溶剂合物中所定义，用式I化合物抑制或调节人类免疫缺陷病毒（HIV）逆转录酶的方法，含有式I的药物组合物 与至少一种溶剂，载体或赋形剂反应，并制备式I化合物。该化合物可用于治疗涉及HIV和遗传相关病毒的疾病