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1.发明授权
公开(公告)号：US5723476A
公开(公告)日：1998-03-03
申请号：US747185
申请日：1996-11-12
申请人： Scott D. Larsen , Jerry R. Colca , Peter K. W. Harris , Howard R. Miller , Alice L. Laborde , Rolf F. Kletzien , Heinrich Josef Schostarez
发明人： Scott D. Larsen , Jerry R. Colca , Peter K. W. Harris , Howard R. Miller , Alice L. Laborde , Rolf F. Kletzien , Heinrich Josef Schostarez
IPC分类号： A61K31/00 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4196 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/665 , A61P3/00 , A61P3/10 , A61P5/50 , C07D311/56 , C07D405/12 , C07D409/12 , C07D417/12 , C07F9/655 , A61K31/35
CPC分类号： C07D405/12 , A61K31/37 , A61K31/381 , A61K31/41 , A61K31/4196 , A61K31/433 , A61K31/4433 , A61K31/665 , C07D311/56 , C07D409/12 , C07D417/12 , C07F9/65522
摘要： The present invention provides some novel 4-hydroxycoumarin-3-carboxamide derivatives and the use of a broad class of 4-hydroxycoumarin-3-carboxamide derivatives for the treatment of a patient suffering from or susceptible to diabetes mellitus.
摘要翻译： 本发明提供一些新的4-羟基香豆素-3-甲酰胺衍生物以及广泛类型的4-羟基香豆素-3-甲酰胺衍生物用于治疗患有糖尿病或易患糖尿病的患者。
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公开(公告)号：US5616320A
公开(公告)日：1997-04-01
申请号：US312016
申请日：1994-09-26
申请人： Alexander D. Argoudelis, deceased , Franklin B. Shilliday , Alice L. Laborde , Scott E. Truesdell , Oldrich K. Sebek
发明人： Alexander D. Argoudelis, deceased , Franklin B. Shilliday , Alice L. Laborde , Scott E. Truesdell , Oldrich K. Sebek
IPC分类号： A23K1/17 , A23K1/18 , C07D405/12 , C12P17/16 , A61K35/00
CPC分类号： C07D405/12 , A23K20/195 , A23K50/30 , C12P17/16 , C12R1/465
摘要： Antibiotic 10381a.sub.1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C.sub.1 to C.sub.3 alkyl ester of antibiotic 10381a.sub.1, are also disclosed along with the pharmaceutically acceptable salts of both the native and esterified forms. Antibiotic 10381a.sub.1 inhibits the growth of selected species of yeast, fungi and bacteria. This invention also relates to a novel process for the preparation of the antibiotics 10381b and to a method of using antibiotics 10381b to promote growth in meat-producing animals. These antibiotics are also obtained by the fermentation of a nutrient medium with the novel microorganism Streptomyces arginensis and are active against selected species of bacteria.
摘要翻译： 其中R为氢的抗生素10381a1是通过在水性介质中培养新型微生物链霉菌Streptomyces arginensis并分离其可生产的含胞嘧啶的抗生素。 其中R是抗生素10381a1的C1-C3烷基酯的衍生物也与天然和酯化形式的药学上可接受的盐一起公开。 抗生素10381a1抑制选定种类的酵母，真菌和细菌的生长。 本发明还涉及制备抗生素10381b的新方法和使用抗生素10381b促进肉制品动物生长的方法。 这些抗生素也通过用新型微生物链霉菌Streptomyces arginensis发酵营养培养基而获得，并且对选定种类的细菌具有活性。
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公开(公告)号：US4276412A
公开(公告)日：1981-06-30
申请号：US76489
申请日：1979-09-17
CPC分类号： C07H5/06 , C12P19/26 , C12R1/01 , Y10S435/822
摘要： Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026.This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria.Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##
摘要翻译： 新型抗生素3-海藻糖胺（U-59,834）可在受控条件下使用新的微生物诺卡氏菌（Nocardiopsis trehalosei sp。）生产。 该抗生素对革兰氏阳性菌，例如金黄色葡萄球菌，枯草芽孢杆菌和肺炎双肺球菌具有活性。 因此，3-海藻胺可用于各种环境中以消除或控制这些细菌。 抗生素3-海藻胺可以通过以下结构式表示：
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4.发明授权Antibiotic 10381A, and process for the preparation of anitbiotics 10381B 失效抗生素10381A，以及制备益生菌10381B的方法公开(公告)号：US06224864B1
公开(公告)日：2001-05-01
申请号：US09371429
申请日：1999-08-10
申请人： Alexander D. Argoudelis , Franklin B. Shilliday , Alice L. Laborde , Scott E. Truesdell , Oldrich K. Sebek
发明人： Alexander D. Argoudelis , Franklin B. Shilliday , Alice L. Laborde , Scott E. Truesdell , Oldrich K. Sebek
IPC分类号： A61K3574
CPC分类号： C07D405/12 , A23K20/195 , A23K50/30 , C12P17/16 , C12R1/465
摘要： Antibiotic 10381a1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C1 to C3 alkyl ester of antibiotic 10381a1, are also disclosed along with the pharmaceutically acceptable salts of both the native and esterified forms. Antibiotic 10381a1 inhibits the growth of selected species of yeast, fungi and bacteria. This invention also relates to a novel process for the preparation of the antibiotics 10381b and to a method of using antibiotics 10381b to promote growth in meat-producing animals. These antibiotics are also obtained by the fermentation of a nutrient medium with the novel microorganism Streptomyces arginensis and are active against selected species of bacteria.
摘要翻译： 其中R为氢的抗生素10381a1是通过在水性介质中培养新型微生物链霉菌Streptomyces arginensis并分离其而产生的含胞嘧啶的抗生素。 其中R是抗生素10381a1的C1-C3烷基酯的衍生物也与天然和酯化形式的药学上可接受的盐一起公开。 抗生素10381a1抑制选定种类的酵母，真菌和细菌的生长。 本发明还涉及制备抗生素10381b的新方法和使用抗生素10381b促进肉制品动物生长的方法。 这些抗生素也通过用新型微生物链霉菌Streptomyces arginensis发酵营养培养基而获得，并且对选定种类的细菌具有活性。
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5.发明授权Biologically pure culture of Nocardiopsis trehalosei sp. nov. 失效Nocardiopsis trehalosei sp。的生物学纯培养 nov。
公开(公告)号：US4306028A
公开(公告)日：1981-12-15
申请号：US195562
申请日：1980-10-09
CPC分类号： C07H5/06 , C07H13/04 , C12P19/26 , C12R1/01 , Y10S435/822
摘要： Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026.This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria.Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##
摘要翻译： 新型抗生素3-海藻糖胺（U-59,834）可在受控条件下使用新的微生物诺卡氏菌（Nocardiopsis trehalosei sp。）生产。 该抗生素对革兰氏阳性菌，例如金黄色葡萄球菌，枯草芽孢杆菌和肺炎双肺球菌具有活性。 因此，3-海藻胺可用于各种环境中以消除或控制这些细菌。 抗生素3-海藻胺可以通过以下结构式表示：
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6.发明授权Antibiotic 10381A.sub.1 and process for the preparation of antibiotics 10381B 失效抗生素10381A1和制备抗生素10381B的方法
公开(公告)号：US5985274A
公开(公告)日：1999-11-16
申请号：US462081
申请日：1995-06-05
申请人： Alexander D. Argoudelis, deceased , Franklin B. Shilliday , Alice L. Laborde , Scott E. Truesdell , Oldrich K. Sebek
发明人： Alexander D. Argoudelis, deceased , Franklin B. Shilliday , Alice L. Laborde , Scott E. Truesdell , Oldrich K. Sebek
CPC分类号： A23K50/30 , A23K20/195
摘要： Antibiotic 10381a.sub.1, wherein R is hydrogen, is a cytosine-containing antibiotic producible by culturing the novel microorganism Streptomyces arginensis in an aqueous medium and isolation thereof. Derivatives wherein R is a C.sub.1 to C.sub.3 alkyl ester of antibiotic 10381a.sub.1, are also disclosed along with the pharmaceutically acceptable salts of both the native and esterified forms. Antibiotic 10381a.sub.1 inhibits the growth of selected species of yeast, fungi and bacteria. This invention also relates to a novel process for the preparation of the antibiotics 10381b and to a method of using antibiotics 10381b to promote growth in meat-producing animals. These antibiotics are also obtained by the fermentation of a nutrient medium with the novel microorganism Streptomyces arginensis and are active against selected species of bacteria.
摘要翻译： 其中R为氢的抗生素10381a1是通过在水性介质中培养新型微生物链霉菌Streptomyces arginensis并分离其而产生的含胞嘧啶的抗生素。 其中R是抗生素10381a1的C1-C3烷基酯的衍生物也与天然和酯化形式的药学上可接受的盐一起公开。 抗生素10381a1抑制选定种类的酵母，真菌和细菌的生长。 本发明还涉及制备抗生素10381b的新方法和使用抗生素10381b促进肉制品动物生长的方法。 这些抗生素也通过用新型微生物链霉菌Streptomyces arginensis发酵营养培养基而获得，并且对选定种类的细菌具有活性。
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公开(公告)号：US4473649A
公开(公告)日：1984-09-25
申请号：US414239
申请日：1982-09-02
申请人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
发明人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
CPC分类号： C12P1/06 , Y10S435/886
摘要： Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.
摘要翻译： 新颖的抗生素U-64,864可在受控条件下使用微生物Streptomyces braegensis Dietz sp.n.，NRRL 12567的生物学纯培养物在发酵过程中生产。该抗生素对各种革兰氏阳性菌如金黄色葡萄球菌，化脓性链球菌 和肺炎链球菌。 因此，抗生素U-64,864可用于各种环境以消除或控制这些细菌。
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公开(公告)号：US4689300A
公开(公告)日：1987-08-25
申请号：US778828
申请日：1985-09-23
IPC分类号： C07D333/32 , C12P17/16 , C12N1/20 , C12P13/02 , C12R1/465
CPC分类号： C12R1/465 , C07D333/32 , C12P17/167 , Y10S435/886
摘要： Novel antibiotic U-68,204 is produced in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces thiolactonus, NRRL 15439. This antibiotic is active against various Gram-positive bacteria. Thus, antibiotic U-68,204 can be used in various environments to eradicate or control such bacteria.
摘要翻译： 新颖的抗生素U-68,204在受控条件下使用微生物硫链霉菌Streptomyces thiolactonus，NRRL 15439的生物学纯培养物在发酵中产生。该抗生素对各种革兰氏阳性细菌具有活性。 因此，抗生素U-68,204可用于各种环境中以消除或控制这些细菌。
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公开(公告)号：US4404190A
公开(公告)日：1983-09-13
申请号：US341437
申请日：1982-01-22
申请人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
发明人： Lester A. Dolak , Fritz Reusser , Thomas M. Castle , Betty R. Hannon , Alice L. Laborde , Charles K. Marschke
CPC分类号： C12P1/06
摘要： Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.
摘要翻译： 新颖的抗生素U-64,864可在受控条件下使用微生物Streptomyces braegensis Dietz sp.n.，NRRL 12567的生物学纯培养物在发酵过程中生产。该抗生素对各种革兰氏阳性菌如金黄色葡萄球菌，化脓性链球菌 和肺炎链球菌。 因此，抗生素U-64,864可用于各种环境以消除或控制这些细菌。
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公开(公告)号：US4310627A
公开(公告)日：1982-01-12
申请号：US195561
申请日：1980-10-09
摘要： Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov., NRRL 12026.This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria.Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##
摘要翻译： 新型抗生素3-海藻糖胺（U-59,834）可在受控条件下使用新的微生物诺卡氏菌（Nocardiopsis trehalosei sp。）生产。 该抗生素对革兰氏阳性菌，例如金黄色葡萄球菌，枯草芽孢杆菌和肺炎双肺球菌具有活性。 因此，3-海藻胺可用于各种环境中以消除或控制这些细菌。 抗生素3-海藻胺可以通过以下结构式表示：
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