摘要:
The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
摘要:
Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要:
Certain embodiments provide a system and method for automatic progressive link management and dispersal. Certain embodiments of a progressive gaming system include a first progressive link, wherein the first progressive link includes a first progressive amount. The system also includes a second progressive link, wherein the second progressive link includes a second progressive amount. The system further includes a progressive manager capable of automatically dispersing to the second progressive amount a portion of the first progressive amount greater than a base amount upon removal of the first progressive link. In an embodiment, the progressive manager calculates the portion of the first progressive amount that is greater than the base amount. In an embodiment, the first and second progressive links are active in multiple gaming environments. The progressive manager may schedule automatic dispersal of the portion of the first progressive amount to a selected progressive amount at a selected time.
摘要:
A method of fabricating a component for a substrate processing chamber involves providing a preform having internal and external surfaces, and providing a mandrel having a textured surface with a pattern of textured features comprising protrusions and depressions. The internal surface of the preform component is contacted with the textured surface of mandrel, and a pressure is applied to the external surface of the preform. The pressure is sufficiently high to plastically deform the preform over the textured surface of the mandrel to form a component having a textured internal surface comprising the pattern of textured feature that are shaped and sized to adhere process residues generated in the processing of substrates.
摘要:
The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
摘要:
Certain embodiments provide a system and method for automatic progressive link management and dispersal. Certain embodiments of a progressive gaming system include a first progressive link, wherein the first progressive link includes a first progressive amount. The system also includes a second progressive link, wherein the second progressive link includes a second progressive amount. The system further includes a progressive manager capable of automatically dispersing to the second progressive amount a portion of the first progressive amount greater than a base amount upon removal of the first progressive link. In an embodiment, the progressive manager calculates the portion of the first progressive amount that is greater than the base amount. In an embodiment, the first and second progressive links are active in multiple gaming environments. The progressive manager may schedule automatic dispersal of the portion of the first progressive amount to a selected progressive amount at a selected time.
摘要:
A system, method, and computer program for dynamically changing the weightings used by a workload distribution program to distribute Enterprise JavaBeans among a group of application servers handling EJBs. The changes are made in response to real-time measurements of the performance of EJBs involved in e-business transactions based on the dynamic insertion of monitors within the EJBs to measure their class and method performance from within the J2EE server. The performance data can be tracked for specific users or specific types of transactions, so that the servers are weighted for optimal handling of the most critical EJBs.
摘要:
The present invention relates generally to inhibitors of the kinases, such as GSK3, and more particularly to fused pyradazine compounds and methods of their use.