摘要:
Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要:
Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要:
An Ethernet physical layer (PHY) module is provided with a method for transceiving between a 10GBASE-R client interface and a 100G attachment interface. On each of ten client interface logical lanes a 10GBASE-R signal is accepted. Each 10GBASE-R logical lane is demultiplexed into two 5 gigabit per second (Gbps) pseudo 100GBASE-R logical lanes, creating a total of twenty pseudo 100GBASE-R logical lanes. The pseudo 100GBASE-R logical lanes are arranged into n groups of 20/n pseudo 100GBASE-R logical lanes. Further, the pseudo 100GBASE-R logical lanes from each group are arranged into a 100G attachment logical lane. Finally, a 100G attachment logical lane is transmitted at an attachment interface on each of n physical lanes. In the reverse direction, each of n physical lanes accepts a 100G attachment logical lane at the attachment interface, and a de-aggregation process supplies a 10GBASE-R signal on each of ten client interface logical lanes.
摘要:
A fluid transfer engine employs a case with a cylindrical inner wall having an operating radius extending from a case axis. A main rotor is carried within the case and incorporates a lobe with a major radius equal to and concentric with the operating radius of the case, the main rotor having a minor radius defining a body. Two peripheral rotors are diametrically opposed with respect to the case axis and rotate within rotor chambers extending from the case. Each peripheral rotor has a radius equal to the minor radius and a center of rotation located at twice the minor radius from the case axis. Each of the peripheral rotors rotates in uniform circular motion with the main rotor in sealing contact with the body and incorporates a sculpted recess for receiving the lobe of the main rotor.
摘要:
The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
摘要:
A method of controlling a tethered, underwater, water current-driven turbine, power-generating device. The device is comprised of dual turbines and dual rotor blades turned by fluid flow, each turbine including one or more generators driven by rotor blades. The device is connected by device tethers to a strut, which is moveable to control depth of the device. The strut is connected to the ocean floor by tripodal tethers: a main tether, a left side tether and a right side tether, which are strut control tethers. One or more winches are controlled to maintain operation of the device within set parameters by varying the tension on one or more of the strut control tethers.
摘要:
Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
摘要:
A pipe handling assembly includes a pipe engaging apparatus having a pipe gripping mechanism connectable to a top drive such that the top drive transmits rotational movement and axial movement to the pipe gripping mechanism. A pipe handling device is mounted onto the pipe engaging apparatus, the pipe handling device including a link hanger mounted on the pipe engaging apparatus. A link arm has a first end pivotally connectable to the link hanger and an outboard end selected to carry a pipe into a position to be gripped by the pipe engaging apparatus. A bearing isolates rotational movement to the pipe gripping mechanism from the link hanger. A connection rigidly connects the link hanger to the pipe engaging apparatus during operation of the pipe handling assembly. The connection is selected to substantially prevent the link hanger from rotating with the pipe gripping mechanism should the bearing seize.
摘要:
A system and method for predictive modeling of building energy consumption provides predicted building energy load values which are determined using kernel smoothing of historical building energy load values for a building using defined scaling factors for scaling predictor variables associated with building energy consumption. Predictor variables may include temperature, humidity, windspeed or direction, occupancy, time, day, date, and solar radiation. Scaling factor values may be defined by optimization training using historical building energy load values and measured predictor variable values for a building. Predicted and measured building energy load values are compared to determine if a preset difference threshold has been exceeded, in which case an alert signal or message is generated and transmitted to electronically and/or physically signal a user. The building energy monitoring system may be integrated with a building automation system, or may be operated as a separate system receiving building energy and predictor variable values.