公开(公告)号：US06363287B1

公开(公告)日：2002-03-26

申请号：US09428191

申请日：1999-10-27

申请人： Scott J. Brabec ,  William Schindeldecker ,  John L. Sommer ,  Douglas S. Hine

发明人： Scott J. Brabec ,  William Schindeldecker ,  John L. Sommer ,  Douglas S. Hine

IPC分类号： A61N105

CPC分类号： A61N1/0568

摘要： A medical electrical lead having an elongated insulative sheath carrying an elongated electrical conductor therein and having a drug-dispensing electrode assembly coupled to a distal end of the elongated conductor. The electrode assembly takes the form of a conductive electrode member having a distal electrode portion exposed exterior to the elongated sheath and a shank portion extending proximally from the distal portion and coupled to the elongated conductor. A drug release device is mounted around the shank proximal to the distal portion of the electrode member and the electrode member is provided with at least one bore extending from a surface of the release device to a surface of the distal portion of the electrode member.

摘要翻译： 一种医用电引线，其具有细长的绝缘护套，其中带有细长的电导体，并且具有联接到细长导体的远端的药物分配电极组件。 电极组件采取导电电极构件的形式，其具有暴露在细长护套外部的远端电极部分和从远侧部分向近侧延伸并联接到细长导体的柄部分。 药物释放装置安装在靠近电极构件的远端部分的柄周围，并且电极构件设置有从释放装置的表面延伸到电极构件的远端部分的表面的至少一个孔。

公开(公告)号：US20120130466A1

公开(公告)日：2012-05-24

申请号：US13301587

申请日：2011-11-21

申请人： John L. Sommer ,  Douglas S. Hine

发明人： John L. Sommer ,  Douglas S. Hine

IPC分类号： A61N1/04

CPC分类号： H01R31/06 ,  A61N1/3752 ,  H01R13/5224 ,  H01R27/00 ,  H01R2201/12

摘要： A lead connector is terminated proximally by a connector pin and includes a circumferential array of connector pads, each connector pad coupled to an electrode via an elongated insulated conductor. A lumen of an adaptor is adapted to engage the lead connector and includes an electrical contact zone formed therein and positioned for coupling with a one of the array of connector pads, when the connector is engaged within the lumen, in order to facilitate electrical connection of a selected electrode corresponding to the one of the array of connector pads.

摘要翻译： 引线连接器由连接器针靠近端接，并且包括连接器焊盘的圆周阵列，每个连接器焊盘通过细长的绝缘导体耦合到电极。 适配器的内腔适于接合引线连接器并且包括形成在其中的电接触区域，并且当连接器接合在内腔内时，该内部定位成与连接器焊盘阵列中的一个连接，以便于电连接 选择的电极对应于所述连接器焊盘阵列中的一个。

公开(公告)号：US07386351B2

公开(公告)日：2008-06-10

申请号：US10136777

申请日：2002-04-30

申请人： Douglas S. Hine ,  John L. Sommer ,  James H. Vaughan ,  Rick D. McVenes ,  Paulus C Van Venrooij ,  Pierre-Andre Grandjean

发明人： Douglas S. Hine ,  John L. Sommer ,  James H. Vaughan ,  Rick D. McVenes ,  Paulus C Van Venrooij ,  Pierre-Andre Grandjean

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61F2/88 ,  A61F2/958 ,  A61N2001/0585

摘要： A medical electrical lead, which may be useful in coupling an implantable medical device, is comprised of a first and second lead. The first lead has a first electrode coupled adjacent a distal end portion thereof. The distal end portion of the first lead is anchorable in the coronary sinus of a patient. The second lead is coupled with and moveable along the first lead. The second lead has a second electrode located thereon wherein the position of the first and second electrodes may be varied relative to one another by movement of the second lead along the first lead. A rubber tip holds the relative position of each electrode.

摘要翻译： 可用于联接可植入医疗装置的医用电引线由第一和第二引线组成。 第一引线具有邻近其远端部分耦合的第一电极。 第一引线的远端部分可锚定在患者的冠状窦中。 第二个领先者与第一个领先者相结合并可以移动。 第二引线具有位于其上的第二电极，其中第一和第二电极的位置可以通过第二引线沿着第一引线的移动而相对于彼此变化。 橡胶尖端保持每个电极的相对位置。

公开(公告)号：US06836687B2

公开(公告)日：2004-12-28

申请号：US10131388

申请日：2002-04-25

申请人： James F. Kelley ,  James H. Vaughn ,  Stanten C. Spear ,  Douglas S. Hine ,  Kenneth C. Gardeski ,  Vicki L. Bjorklund ,  Pedro A. Meregotte ,  John L. Sommer ,  John J. Maier

发明人： James F. Kelley ,  James H. Vaughn ,  Stanten C. Spear ,  Douglas S. Hine ,  Kenneth C. Gardeski ,  Vicki L. Bjorklund ,  Pedro A. Meregotte ,  John L. Sommer ,  John J. Maier

IPC分类号： A61N105

CPC分类号： A61M25/0138 ,  A61B18/1492 ,  A61B2017/22038 ,  A61M25/005 ,  A61M25/0054 ,  A61M25/0141 ,  A61M25/0147 ,  A61M25/0668 ,  A61M39/0613 ,  A61M2025/0042 ,  A61M2025/0047 ,  A61M2025/0081 ,  A61M2025/0161 ,  A61M2025/0681 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61N1/05 ,  A61N1/056 ,  A61N2001/0578 ,  A61N2001/0585

摘要： A system for delivering a medical electrical lead within a coronary venous system that includes an introducer kit for establishing venous access to the coronary venous system and a plurality of delivery sheaths, each corresponding to a desired approach to a coronary sinus of the coronary venous system and insertable within the coronary venous system through the navigation pathway. A hemostasis valve is coupled to a delivery sheath of the plurality of delivery sheaths, and a guide wire is inserted within the lead lumen, guiding delivery of the distal tip of the medical electrical lead to a target site within the coronary venous system through the hemostasis valve and the delivery sheath. Subsequent to the distal tip being delivered to the target sight, the hemostasis valve is advanced over the connector of the medical electrical lead to remove the hemostasis valve from the medical electrical lead.

摘要翻译： 一种用于在冠状静脉系统内递送医用电线的系统，其包括用于建立对冠状静脉系统的静脉通路的引导器套件和多个输送护套，每个输送护套对应于冠状静脉系统的冠状窦所需的方法， 通过导航路径插入冠状静脉系统内。 止血阀联接到多个输送护套的输送护套，并且引导线插入引导腔内，通过止血将医用电导线的远端引导到冠状静脉系统内的靶位点 阀门和输送护套。 在远端尖端被传送到目标瞄准器之后，止血阀在医用电线的连接器上前进，以从医用电引线上除去止血阀。

公开(公告)号：US20120232605A1

公开(公告)日：2012-09-13

申请号：US13357646

申请日：2012-01-25

申请人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

发明人： Yong-Fu Xiao ,  Jeffrey M. Gillberg ,  Paul J. DeGroot ,  Eduardo N. Warman ,  Scott J. Brabec ,  John L. Sommer ,  Jon F. Urban ,  Lepeng Zeng

IPC分类号： A61N1/365

CPC分类号： A61N1/365 ,  A61N1/3622 ,  A61N1/36585

摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.

摘要翻译： 通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。 响应于感测到的心室去极化，检测到快速心室率。 响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。 确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。

公开(公告)号：US08639340B2

公开(公告)日：2014-01-28

申请号：US10635166

申请日：2003-08-06

申请人： John L. Sommer ,  Douglas S. Hine ,  Douglas N. Hess

发明人： John L. Sommer ,  Douglas S. Hine ,  Douglas N. Hess

IPC分类号： A61N1/375

CPC分类号： A61N1/3752

摘要： A connector sleeve includes a lumen adapted to receive a medical lead connector wherein a retention element engages a retention edge formed at a distal end of a connector element included on the lead connector. The connector sleeve further includes a contact element adapted to electrically engage the lead connector element within the lumen and an external conductive surface electrically coupled to the contact element and adapted for electrical engagement within the connector bore of an implantable medical device.

摘要翻译： 连接器套管包括适于接收医疗引线连接器的内腔，其中保持元件接合形成在包括在引线连接器上的连接器元件的远端处的保持边缘。 连接器套筒还包括适于电连接腔内的引线连接器元件的接触元件和电耦合到接触元件的外部导电表面，并且适于电连接在可植入医疗器械的连接器孔内。

公开(公告)号：US08019420B2

公开(公告)日：2011-09-13

申请号：US10646545

申请日：2003-08-21

申请人： Douglas S. Hine ,  John L. Sommer ,  John Gurley

发明人： Douglas S. Hine ,  John L. Sommer ,  John Gurley

IPC分类号： A61N1/375

CPC分类号： H01R13/5224 ,  H01R31/06

摘要： A lead connector including a connector element array is fitted into a selected adaptor from a plurality of adaptors to electrically couple one or more elements of the connector element array, corresponding to one or more selected electrodes from an array of lead electrodes, to one or more contact zones of the selected adaptor in order to facilitate electrical connection with an implantable medical device.

摘要翻译： 将包括连接器元件阵列的引线连接器从多个适配器装配到所选择的适配器中，以将来自引线电极阵列的一个或多个所选电极的连接器元件阵列的一个或多个元件电耦合到一个或多个 接触区域，以便于与可植入医疗设备的电连接。

公开(公告)号：US20080300664A1

公开(公告)日：2008-12-04

申请号：US12115961

申请日：2008-05-06

申请人： DOUGLAS S. HINE ,  John L. Sommer ,  James H. Vaughan ,  Rick D. McVenes ,  Paulus C. Van Venrooij ,  Pierre-Andre Grandjean

发明人： DOUGLAS S. HINE ,  John L. Sommer ,  James H. Vaughan ,  Rick D. McVenes ,  Paulus C. Van Venrooij ,  Pierre-Andre Grandjean

IPC分类号： A61N1/05 ,  A61B5/042

CPC分类号： A61N1/056 ,  A61F2/88 ,  A61F2/958 ,  A61N2001/0585

摘要： A medical electrical lead, which may be useful in coupling an implantable medical device, is comprised of a first and second lead. The first lead has a first electrode coupled adjacent a distal end portion thereof. The distal end portion of the first lead is anchorable in the coronary sinus of a patient. The second lead is coupled with and moveable along the first lead. The second lead has a second electrode located thereon wherein the position of the first and second electrodes may be varied relative to one another by movement of the second lead along the first lead. A rubber tip holds the relative position of each electrode.

摘要翻译： 可用于联接可植入医疗装置的医用电引线由第一和第二引线组成。 第一引线具有邻近其远端部分耦合的第一电极。 第一引线的远端部分可锚定在患者的冠状窦中。 第二个领先者与第一个领先者相结合并可以移动。 第二引线具有位于其上的第二电极，其中第一和第二电极的位置可以通过第二引线沿着第一引线的移动而相对于彼此变化。 橡胶尖端保持每个电极的相对位置。

公开(公告)号：US07076309B2

公开(公告)日：2006-07-11

申请号：US10137466

申请日：2002-04-30

申请人： Douglas S. Hine ,  John L. Sommer ,  Vicki L. Bjorklund ,  Bernhard Kupper

发明人： Douglas S. Hine ,  John L. Sommer ,  Vicki L. Bjorklund ,  Bernhard Kupper

IPC分类号： A61N1/05 ,  A61B5/042

CPC分类号： A61N1/057 ,  A61N2001/0578

摘要： An electrical lead includes an elongate body having a proximal end and a fixation member joined to the elongate body and distally disposed from the proximal end of the elongate body, wherein the fixation member is capable of being extended from and retracted toward the elongate body. A method includes advancing an electrical lead into vasculature and extending a fixation member from the body of the electrical lead to fixedly engage the electrical lead within the vasculature. The method may further include retracting the fixation member toward the body of the electrical lead to unengage the electrical lead within the vasculature and retracting the electrical lead from the vasculature.

公开(公告)号：US06733500B2

公开(公告)日：2004-05-11

申请号：US10131672

申请日：2002-04-24

申请人： James F. Kelley ,  James H. Vaughn ,  Stanten C. Spear ,  Douglas S. Hine ,  Kenneth C. Gardeski ,  Vicki L. Bjorklund ,  Pedro A. Meregotte ,  John L. Sommer ,  John J. Maier

发明人： James F. Kelley ,  James H. Vaughn ,  Stanten C. Spear ,  Douglas S. Hine ,  Kenneth C. Gardeski ,  Vicki L. Bjorklund ,  Pedro A. Meregotte ,  John L. Sommer ,  John J. Maier

IPC分类号： A61B1818

CPC分类号： A61M25/0138 ,  A61B18/1492 ,  A61B2017/22038 ,  A61M25/005 ,  A61M25/0054 ,  A61M25/0141 ,  A61M25/0147 ,  A61M25/0668 ,  A61M25/09 ,  A61M25/09041 ,  A61M2025/0042 ,  A61M2025/0047 ,  A61M2025/0081 ,  A61M2025/0161 ,  A61M2025/0681 ,  A61M2025/1052 ,  A61M2025/1079 ,  A61N1/056 ,  A61N1/06 ,  A61N1/372 ,  A61N2001/0578 ,  A61N2001/0585

摘要： A loading device for loading a guide wire within a medical electrical lead that includes a navigation portion, having an outer portion, and extending from a front end to a back end, and having an opening formed at the back end. An engagement cavity receives and properly orientates the lead distal tip to align the lumen of the lead with the opening of the navigation portion during the loading of the guide wire within the lead. A first side wall is spaced from a second side wall to form a slot extending along the outer portion from the front end to the back end of the navigation portion, and the guide wire is advanced through the slot as the lead having the guide wire loaded therein is removed from the loading device.

摘要翻译： 一种用于将导丝装载在医疗用电线内的装载装置，其包括具有外部的导航部，并且从前端延伸到后端，并且具有形成在后端的开口。 接合腔容纳并适当地定向引线远侧末端，以在引导线在引线内的加载期间使引线的内腔与引导部分的开口对准。 第一侧壁与第二侧壁间隔开以形成沿着导引部分的前端到后端的外部部分延伸的狭槽，并且当导线加载有引导线时，引导线前进通过狭槽 其中的装载装置被移除。