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    Device and method for extracting body fluid
    3.
    发明申请
    Device and method for extracting body fluid 审中-公开
    用于提取体液的装置和方法

    公开(公告)号：US20050113739A1

    公开(公告)日：2005-05-26

    申请号：US10718818

    申请日：2003-11-21

    申请人： Matthias Stiene ,  Michael Hilgers ,  Tanja Richter

    发明人： Matthias Stiene ,  Michael Hilgers ,  Tanja Richter

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157 ,  A61B17/20 ,  A61M1/00

    CPC分类号： A61B5/15117 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150511 ,  A61B5/150526 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/1519

    摘要： A device for extracting bodily fluid (such as an ISF sample) includes a penetration member with a channel (e.g., a hollow needle) and a fluid flow regulator (for example, a narrow-bore cylinder) disposed within the channel. The penetration member is configured for penetrating a target site (such as a dermal tissue target site) and subsequently residing within the target site and extracting a bodily fluid sample therefrom. The fluid flow regulator is adapted to control (e.g., reduce or minimize variation in) bodily fluid flow rate through the penetration member. In addition, the presence of the fluid flow regulator in the channel of the penetration member serves to reduce sensor lag by reducing the dead volume of the penetration member. A method for extracting bodily fluid from a target site includes providing the aforementioned device. Next, the target site is penetrated with the penetration member of the device. Subsequently, bodily fluid is extracted from the target site via the penetration member and the fluid flow regulator of the device.

    摘要翻译： 用于提取体液（例如ISF样品）的装置包括具有通道（例如空心针）的穿透构件和设置在通道内的流体流量调节器（例如，窄孔缸）。 穿透构件被构造成用于穿透靶部位（例如真皮组织靶位点）并随后驻留在靶位点内并从其中提取体液样品。 流体流量调节器适于通过穿透构件控制（例如，减小或最小化）体液流速的变化。 此外，流体流量调节器在穿透构件的通道中的存在用于通过减少穿透构件的死体积来减小传感​​器滞后。 从目标部位提取体液的方法包括提供上述装置。 接下来，目标部位用装置的穿透部件穿透。 随后，通过穿透构件和装置的流体流动调节器从目标部位提取体液。

    Method for extracting interstitial fluid
    5.
    发明申请
    Method for extracting interstitial fluid 审中-公开
    提取组织液的方法

    公开(公告)号：US20070038147A1

    公开(公告)日：2007-02-15

    申请号：US11203020

    申请日：2005-08-11

    申请人： Joel Mechelke ,  Thomas Rademacher ,  Michael Hilgers ,  Phil Stout

    发明人： Joel Mechelke ,  Thomas Rademacher ,  Michael Hilgers ,  Phil Stout

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1519 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117 ,  A61B10/0045 ,  A61B2010/008

    摘要： A method for extracting interstitial fluid from a target site of a user includes adhesively attaching a floating ring of a sampling module for extracting interstitial fluid to the user in the vicinity of a target site and then mounting the sampling module to the floating ring and attaching the sampling module to the user. Subsequently, the target site is penetrated with a penetration member of the sampling module. Pressure is then applied in another vicinity of the target site by a pressure ring of the sampling module and, thereafter, ISF extracted from the target site via a penetration member of the sampling module.

    摘要翻译： 从用户的目标部位提取组织液的方法包括将目标部位附近的使用者提取组织液的取样模块的浮环粘合地附着，然后将取样模块安装在浮环上， 采样模块给用户。 随后，用采样模块的穿透部件穿透目标部位。 然后通过采样模块的压力环将压力施加在目标位置的另一个附近，然后通过采样模块的穿透构件从目标位置提取ISF。

    Sampling module for extracting interstitial fluid
    7.
    发明申请
    Sampling module for extracting interstitial fluid 审中-公开
    用于提取组织液的取样模块

    公开(公告)号：US20070038148A1

    公开(公告)日：2007-02-15

    申请号：US11203022

    申请日：2005-08-11

    申请人： Joel Mechelke ,  Thomas Rademacher ,  Michael Hilgers ,  Phil Stout

    发明人： Joel Mechelke ,  Thomas Rademacher ,  Michael Hilgers ,  Phil Stout

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1519 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117 ,  A61B10/0045 ,  A61B2010/008

    摘要： A sampling module for extracting interstitial fluid (ISF) from a user's body includes a housing assembly and a pressure ring assembly operatively contained within the housing assembly. The pressure ring assembly includes a penetration member configured for penetrating a target site of the user's body and, subsequently, residing in the target site and extracting ISF therefrom. The pressure ring assembly also includes a pressure ring configured for applying pressure to the user's body in a first vicinity of the target site and a floating ring with an adhesive layer disposed on it's distal end. The adhesive layer of the sampling module provides for adhesive attachment of the floating ring to the user's body in a second vicinity of the target site, thereby influencing target site deformation during use of the sampling module.

    摘要翻译： 用于从使用者身体提取组织液（ISF）的采样模块包括壳体组件和可操作地容纳在壳体组件内的压力环组件。 所述压力环组件包括穿透构件，所述穿透构件被构造用于穿透所述使用者身体的目标部位，并且随后驻留在所述目标部位并从其中提取ISF。 压力环组件还包括压力环，该压力环被配置为在目标位置的第一附近向使用者的身体施加压力，以及具有设置在其远端上的粘合剂层的浮动环。 采样模块的粘合剂层在目标位置的第二附近提供浮动环粘合到使用者的身体上，从而在使用采样模块期间影响目标位置变形。

    Devices and methods for extracting bodily fluid
    8.
    发明申请
    Devices and methods for extracting bodily fluid 审中-公开
    用于提取体液的装置和方法

    公开(公告)号：US20050187525A1

    公开(公告)日：2005-08-25

    申请号：US10783289

    申请日：2004-02-19

    申请人： Michael Hilgers ,  Devin McAllister ,  Adolfo Menendez

    发明人： Michael Hilgers ,  Devin McAllister ,  Adolfo Menendez

    IPC分类号： A61B5/15 ,  A61B10/00 ,  A61M5/00 ,  A61B5/00 ,  A61M25/00 ,  B65D81/00

    CPC分类号： A61B10/0045 ,  A61B2010/008

    摘要： A bodily fluid extraction device includes a penetration member configured for penetrating a target site and subsequently residing within the target site and extracting a bodily fluid sample. The penetration member includes a proximal end adapted for fluid communication with an analyte analysis system, a distal end, and a channel extending from the distal to the proximal end. The distal end includes a sharp portion for penetrating a target site, and a flexible feature adapted for promoting bodily fluid flow into the channel by protruding into the target site after the penetration member has penetrated the target site. A method for extracting bodily fluid includes providing a bodily fluid extraction device as described immediately above. Subsequently, a target site is penetrated with the distal end of the bodily fluid extraction device's penetration member and the flexible portion of the penetration member is caused to protrude into the target site and promote bodily fluid flow into the penetration member's channel. Bodily fluid (e.g., ISF) is then extracted from the target site (e.g., a dermal tissue target site) via the channel of the bodily fluid extraction device.

    摘要翻译： 体液提取装置包括穿透构件，该穿透构件被构造用于穿透目标部位并且随后驻留在目标部位内并提取体液样品。 穿透构件包括适于与分析物分析系统，远端和从远端延伸到近端的通道的流体连通的近端。 远端包括用于穿透目标部位的尖锐部分，以及柔性特征，其适于在穿透部件已经穿透目标部位之后通过突出到目标部位中来促进体液流入通道。 一种用于提取体液的方法包括提供如上所述的体液提取装置。 随后，目标部位穿过体液提取装置的穿透部件的远端，使穿透部件的柔性部分突出到目标部位，并促使体液流入穿透部件的通道。 然后经由体液提取装置的通道从目标部位（例如，真皮组织靶位点）提取体液（例如ISF）。