公开(公告)号：US07258673B2

公开(公告)日：2007-08-21

申请号：US10653023

申请日：2003-08-28

申请人： Joel Racchini ,  Michael Hilgers ,  Phil Stout ,  Thomas Rademacher ,  Joel Mechelke ,  Cass A. Hanson

发明人： Joel Racchini ,  Michael Hilgers ,  Phil Stout ,  Thomas Rademacher ,  Joel Mechelke ,  Cass A. Hanson

IPC分类号： A61B5/00 ,  A61B17/14 ,  A61B17/32

CPC分类号： A61B5/14532 ,  A61B5/002 ,  A61B5/022 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/157 ,  A61B5/6824 ,  A61B2560/0431 ,  A61B2562/0295

摘要： An interstitial fluid (ISF) extraction device includes a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom and at least three concentrically-arranged pressure rings, each adapted for applying pressure to the user's skin layer in the vicinity of the target site while the penetration member is residing in the user's skin layer. In addition, the ISF extraction device is configured such that (i) the pressure rings apply pressure in an oscillating manner with asymmetric deployment and retraction cycles and (ii) only one of the at least three concentrically-arranged pressure rings is deployed at a time, thereby mitigating an ISF glucose lag of the ISF sample extracted by the penetration member.

摘要翻译： 间质液体（ISF）提取装置包括穿透构件，其被配置用于穿透使用者皮肤层的目标部位，并且随后驻留在使用者的皮肤层中并从其中提取ISF样品和至少三个同心布置的压力环 适于在穿透构件驻留在使用者的皮肤层中时在目标部位附近向使用者的皮肤层施加压力。 另外，ISF提取装置被配置成使得（i）压力环以不对称展开和缩回循环的振荡方式施加压力，并且（ii）一次只部署至少三个同心布置的压力环中的一个 从而减轻由穿透构件提取的ISF样品的ISF葡萄糖滞后。

公开(公告)号：US20080033320A1

公开(公告)日：2008-02-07

申请号：US11842502

申请日：2007-08-21

申请人： Joel Racchini ,  Michael Hilgers ,  Phil Stout ,  Thomas Rademacher ,  Joel Mechelke ,  Gass Hanson

发明人： Joel Racchini ,  Michael Hilgers ,  Phil Stout ,  Thomas Rademacher ,  Joel Mechelke ,  Gass Hanson

IPC分类号： A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/002 ,  A61B5/022 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/157 ,  A61B5/6824 ,  A61B2560/0431 ,  A61B2562/0295

摘要： An interstitial fluid (ISF) extraction device includes a penetration member configured for penetrating a target site of a user's skin layer and, subsequently, residing in the user's skin layer and extracting an ISF sample therefrom and at least three concentrically-arranged pressure rings, each adapted for applying pressure to the user's skin layer in the vicinity of the target site while the penetration member is residing in the user's skin layer. In addition, the ISF extraction device is configured such that (i) the pressure rings apply pressure in an oscillating manner with asymmetric deployment and retraction cycles and (ii) only one of the at least three concentrically-arranged pressure rings is deployed at a time, thereby mitigating an ISF glucose lag of the ISF sample extracted by the penetration member.

摘要翻译： 间质液体（ISF）提取装置包括穿透构件，其被配置用于穿透使用者皮肤层的目标部位，并且随后驻留在使用者的皮肤层中并从其中提取ISF样品和至少三个同心布置的压力环 适于在穿透构件驻留在使用者的皮肤层中时在目标部位附近向使用者的皮肤层施加压力。 另外，ISF提取装置被配置成使得（i）压力环以不对称展开和缩回循环的振荡方式施加压力，并且（ii）一次只部署至少三个同心布置的压力环中的一个 从而减轻由穿透构件提取的ISF样品的ISF葡萄糖滞后。

公开(公告)号：US20060036187A1

公开(公告)日：2006-02-16

申请号：US10882994

申请日：2004-06-30

申请人： Hester Vos ,  Simon Kaar ,  Frank Wehrheim ,  Joel Racchini ,  Michael Hilgers ,  Phil Stout ,  Thomas Rademacher ,  Joel Mechelke ,  Cass Hanson

发明人： Hester Vos ,  Simon Kaar ,  Frank Wehrheim ,  Joel Racchini ,  Michael Hilgers ,  Phil Stout ,  Thomas Rademacher ,  Joel Mechelke ,  Cass Hanson

IPC分类号： A61B5/00

CPC分类号： A61B5/1486 ,  A61B5/0002 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150083 ,  A61B5/150114 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150816 ,  A61B5/150862 ,  A61B5/150969 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1519

摘要： Systems and methods are provided for extracting a bodily fluid sample (e.g., an interstitial fluid sample) and monitoring an analyte therein. Certain of the systems include a a penetration member configured for penetrating and residing in a target site of a user's skin layer and, subsequently, extracting a fluid sample therefrom. The system also includes a pressure ring(s) adapted for applying pressure to the user's skin layer in the vicinity of the target site. The system is configured such that the pressure ring(s) is capable of applying pressure in an oscillating manner. Certain methods include penetrating the skin and applying pressure to the skin in an oscillating manner.

摘要翻译： 提供用于提取体液样品（例如，间质液样品）并监测其中的分析物的系统和方法。 某些系统包括穿透构件，其构造成用于穿透和驻留在使用者皮肤层的目标部位中，并且随后从其中提取流体样品。 该系统还包括适于在目标位置附近向用户的皮肤层施加压力的压力环。 该系统构造成使得压力环能够以振荡方式施加压力。 某些方法包括穿透皮肤并以振荡方式对皮肤施加压力。

公开(公告)号：US20050002018A1

公开(公告)日：2005-01-06

申请号：US10896227

申请日：2004-07-20

申请人： Brian Erickson ,  Philip Stout ,  Joel Racchini

发明人： Brian Erickson ,  Philip Stout ,  Joel Racchini

IPC分类号： G01N21/31 ,  G01J1/00 ,  A61B5/00

CPC分类号： G01N21/314 ,  G01N2021/3137 ,  G01N2021/3166 ,  G01N2021/3188

摘要： An analyte (e.g., glucose) is tested in a sample (e.g., blood or blood-free interstitial fluid) having both the analyte and other constituents (e.g., protein). The analyte has an absorption peak over a narrow bandwidth at a characteristic wavelength. The other constituents have an absorption over a broad bandwidth. The broad bandwidth includes and is broader than the narrow bandwidth. Radiant energy (e.g., IR radiation) is directed at the sample. The energy has a source bandwidth including the broad bandwidth. The sample absorbs a portion of the energy. A remainder of the energy is available for analysis. The remainder is analyzed by filtering the remainder into an analyte portion and a reference portion. The analyte portion contains substantially only the narrow bandwidth. The reference portion contains substantially only the broad bandwidth. The analyte portion and the reference portion are measured and compared to calculate an amount of the analyte in the sample.

摘要翻译： 在具有分析物和其他成分（例如蛋白质）的样品（例如，血液或无血液的间质液）中测试分析物（例如葡萄糖）。 分析物在特征波长处的窄带宽上具有吸收峰。 其他成分在宽带宽上具有吸收。 宽带宽包括窄带宽。 辐射能量（例如，IR辐射）指向样品。 能量具有包括宽带宽的源带宽。 样品吸收一部分能量。 剩余的能量可用于分析。 通过将剩余部分过滤成分析物部分和参考部分来分析剩余部分。 分析物部分基本上仅包含窄带宽。 参考部分基本上仅包含宽带宽。 测量分析物部分和参考部分并比较样品中分析物的量。

公开(公告)号：US20050180881A1

公开(公告)日：2005-08-18

申请号：US11069392

申请日：2005-02-28

申请人： John Allen ,  Joel Racchini

发明人： John Allen ,  Joel Racchini

IPC分类号： G01N33/48 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/15 ,  A61B5/157 ,  B01L3/00 ,  G01N27/28 ,  G01N27/416 ,  G01N33/483 ,  G01N33/487 ,  G01N31/22

CPC分类号： B01L3/502715 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150519 ,  A61B5/15105 ,  A61B5/15142 ,  A61B5/157 ,  A61B2562/0295 ,  B01L3/5023 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0825 ,  B01L2300/161 ,  B01L2400/0406 ,  Y10T436/2575

摘要： A body fluid is collected for testing for an analyte contained within the body fluid. The fluid is collected in an apparatus including a reservoir for receiving and collecting a flow of body fluid from a discharge end of a conduit. A capillary test space is in fluid flow communication with the reservoir. The capillary test space is positioned to be in contact with the fluid in the reservoir after the fluid has accumulated to a predetermined transfer volume of fluid. The capillary test space is sized to wick the fluid from the reservoir when the fluid contacts the capillary test space.

摘要翻译： 收集体液以测试体液中包含的分析物。 将流体收集在包括用于从导管的排出端接收和收集体液的流体的储存器的装置中。 毛细管测试空间与储存器流体流动连通。 毛细管测试空间定位成在流体积聚到预定的传送体积的流体之后与储存器中的流体接触。 当流体接触毛细管测试空间时，毛细管测试空间的大小适于吸收来自储存器的流体。