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公开(公告)号：US07601809B2
公开(公告)日：2009-10-13
申请号：US11539072
申请日：2006-10-05
IPC分类号： C07K14/715 , C07K14/54
CPC分类号： C07K14/47 , C07K14/715 , C07K2319/00 , Y10T436/143333
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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2.发明申请ZCYTOR19 HETERODIMERIC CYTOKINE RECEPTOR POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS 审中-公开ZCYTOR19高分子细胞因子受体多核苷酸，多肽，抗体和方法公开(公告)号：US20110171627A1
公开(公告)日：2011-07-14
申请号：US12723364
申请日：2010-03-12
申请人： Scott R. Presnell , Francis J. Grant , Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
发明人： Scott R. Presnell , Francis J. Grant , Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
CPC分类号： C07K14/7155
摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了与IL-28R和CRF2-4形成异二聚体受体复合物的新方法。 该方法可用于体外和体内检测和治疗病毒感染。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 本发明还包括生产蛋白质的方法，用途及其抗体。
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3.发明申请公开(公告)号：US20110091876A1
公开(公告)日：2011-04-21
申请号：US12756985
申请日：2010-04-08
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C12P21/00 , C07K14/00 , C07K16/18 , G01N33/53
CPC分类号： C07K14/47 , C07K14/715 , C07K2319/00 , Y10T436/143333
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US07217790B2
公开(公告)日：2007-05-15
申请号：US10660968
申请日：2003-09-12
申请人： Wenfeng Xu , Catherine E. Lofton-Day , Randal M. Henne , Scott R. Presnell , Yue Yao , Julia E. Novak
发明人： Wenfeng Xu , Catherine E. Lofton-Day , Randal M. Henne , Scott R. Presnell , Yue Yao , Julia E. Novak
IPC分类号： C07K14/00
CPC分类号： C07K14/7151
摘要： Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.
摘要翻译： 公开了新型分泌的和膜结合的肿瘤坏死因子受体（TNFR）多肽，编码多肽的多核苷酸，抗体及相关组合物和方法。 多肽可用于检测配体，激动剂和拮抗剂。 多肽，多核苷酸和抗体也可用于调节炎症，肿瘤生长和转移，感染，免疫和细胞成熟的方法中。
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公开(公告)号：US07704950B2
公开(公告)日：2010-04-27
申请号：US11690915
申请日：2007-03-26
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US08133487B2
公开(公告)日：2012-03-13
申请号：US12695069
申请日：2010-01-27
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention provides methods of treating psoriasis in a subject (i.e., psoriasis associated with a joint disease), by administering to the subject an effective dose of a composition comprising a soluble IL-22R/IL-20RB heterodimeric polypeptide, wherein the heterodimeric polypeptide comprises an IL-22R extracellular domain covalently linked to an IL-20RB extracellular domain.
摘要翻译： 本发明提供了通过向受试者施用有效剂量的包含可溶性IL-22R / IL-20RB异源二聚体多肽的组合物来治疗受试者中的牛皮癣（即，与关节疾病相关的牛皮癣）的方法，其中所述异二聚体多肽 包含与IL-20RB细胞外结构域共价连接的IL-22R细胞外结构域。
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公开(公告)号：US20110150872A1
公开(公告)日：2011-06-23
申请号：US12695069
申请日：2010-01-27
IPC分类号： A61K39/395 , A61K38/17 , A61P29/00 , A61P17/06 , A61P19/02
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 结合具有两个多肽亚基IL-22R和IL-20RB的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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8.发明申请ZCYTOR19 HETERODIMERIC CYTOKINE RECEPTOR POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS 审中-公开ZCYTOR19高分子细胞因子受体多核苷酸，多肽，抗体和方法公开(公告)号：US20120053321A1
公开(公告)日：2012-03-01
申请号：US13252723
申请日：2011-10-04
申请人： Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
发明人： Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
CPC分类号： C07K14/7155
摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了与IL-28R和CRF2-4形成异二聚体受体复合物的新方法。 该方法可用于体外和体内检测和治疗病毒感染。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 本发明还包括生产蛋白质的方法，用途及其抗体。
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9.发明授权公开(公告)号：US08217008B2
公开(公告)日：2012-07-10
申请号：US12899700
申请日：2010-10-07
申请人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
发明人： Donald C. Foster , Wenfeng Xu , Karen L. Madden , James D. Kelly , Cindy A. Sprecher , Cameron S. Brandt , Mark W. Rixon , Scott R. Presnell , Brian A. Fox
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US07812130B2
公开(公告)日：2010-10-12
申请号：US12573046
申请日：2009-10-02
申请人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
发明人： Scott R. Presnell , Wenfeng Xu , Wayne Kindsvogel , Zhi Chen
IPC分类号： C07K14/00
CPC分类号： C07K14/715 , A61K38/00 , C07K2319/00
摘要： Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”
摘要翻译： 细胞因子及其受体已被证明在基础研究和治疗方面都是有用的。 本发明提供了称为“Zcytor16”的新的人细胞因子受体。
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