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    Medical devices visible by magnetic resonance imaging
    1.
    发明授权
    Medical devices visible by magnetic resonance imaging 有权
    磁共振成像可见的医疗器械

    公开(公告)号：US08620406B2

    公开(公告)日：2013-12-31

    申请号：US10763690

    申请日：2004-01-23

    申请人： Scott R. Smith ,  Steven E. Walak ,  Lixiao Wang ,  Jan Weber ,  Sheng-Ping Zhong

    发明人： Scott R. Smith ,  Steven E. Walak ,  Lixiao Wang ,  Jan Weber ,  Sheng-Ping Zhong

    IPC分类号： A61B5/05

    CPC分类号： G01R33/285 ,  A61B2090/3954 ,  A61M25/0043 ,  A61M25/0127 ,  G01R33/286

    摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.

    摘要翻译： 描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。 在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。 导电路径能够连接到电流源。 医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

    Magnetic resonance imaging of a medical device and proximate body tissue
    2.
    发明授权
    Magnetic resonance imaging of a medical device and proximate body tissue 有权
    医疗器械和邻近身体组织的磁共振成像

    公开(公告)号：US07483732B2

    公开(公告)日：2009-01-27

    申请号：US10826960

    申请日：2004-04-15

    申请人： Sheng-Ping Zhong ,  Michael N Helmus ,  Scott R. Smith ,  Bruce E. Hammer

    发明人： Sheng-Ping Zhong ,  Michael N Helmus ,  Scott R. Smith ,  Bruce E. Hammer

    IPC分类号： A61B5/05 ,  G01V3/00

    CPC分类号： G01R33/285

    摘要： Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.

    摘要翻译： 医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。 此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。 第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。 在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。 第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。

    Stent coating
    3.
    发明授权
    Stent coating 失效
    支架涂层

    公开(公告)号：US06569195B2

    公开(公告)日：2003-05-27

    申请号：US09883870

    申请日：2001-06-18

    申请人： Dachuan Yang ,  Joel L. Stanslaski ,  Lixiao Wang ,  Scott R. Smith

    发明人： Dachuan Yang ,  Joel L. Stanslaski ,  Lixiao Wang ,  Scott R. Smith

    IPC分类号： A61F206

    CPC分类号： A61K9/0024 ,  A61F2/91 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/608 ,  C08L67/04

    摘要： A stent having a polymeric coating for controllably releasing an included active agent. The polymeric coating includes a blend of a first polymeric material, which if alone, would release the agent at a first, higher rate, and a second polymeric material, which if alone would release the agent at a second, lower rate over a longer time period. One stent coating utilizes a faster releasing hydrophilic polymeric material and a slower releasing hydrophobic material. One stent coating includes a blend of a faster releasing PLA-PEO copolymer and a slower releasing PLA-PCL copolymer. One active agent is Taxol. One use of the Taxol delivering stent is to inhibit restenosis following angioplasty.

    摘要翻译： 具有用于可控地释放所包括的活性剂的聚合物涂层的支架。 聚合物涂层包括第一聚合物材料的混合物，如果单独的话，将以第一较高速率释放试剂和第二聚合物材料，如果单独将在较长时间内以第二较低的速率释放试剂 期。 一个支架涂层使用更快释放的亲水聚合物材料和较慢释放的疏水材料。 一个支架涂层包括较快释放的PLA-PEO共聚物和较慢释放的PLA-PCL共聚物的共混物。 一种活性剂是紫杉醇。 输送紫杉醇的一种用途是在血管成形术后抑制再狭窄。

    Stent coating
    4.
    发明授权
    Stent coating 失效
    支架涂层

    公开(公告)号：US06258121B1

    公开(公告)日：2001-07-10

    申请号：US09346975

    申请日：1999-07-02

    申请人： Dachuan Yang ,  Joel L. Stanslaski ,  Lixiao Wang ,  Scott R. Smith

    发明人： Dachuan Yang ,  Joel L. Stanslaski ,  Lixiao Wang ,  Scott R. Smith

    IPC分类号： A61F206

    CPC分类号： A61K9/0024 ,  A61F2/91 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/608 ,  C08L67/04

    摘要： A stent having a polymeric coating for controllably releasing an included active agent. The polymeric coating includes a blend of a first polymeric material, which if alone, would release the agent at a first, higher rate, and a second polymeric material, which if alone would release the agent at a second, lower rate over a longer time period. One stent coating utilizes a faster releasing hydrophilic polymeric material and a slower releasing hydrophobic material. One stent coating includes a blend of a faster releasing PLA-PEO copolymer and a slower releasing PLA-PCL copolymer. One active agent is Taxol. One use of the Taxol delivering stent is to inhibit restenosis following angioplasty.

    摘要翻译： 具有用于可控地释放所包括的活性剂的聚合物涂层的支架。 聚合物涂层包括第一聚合物材料的混合物，如果单独的话，将以第一较高速率释放试剂和第二聚合物材料，如果单独将在较长时间内以第二较低的速率释放试剂 期。 一个支架涂层使用更快释放的亲水聚合物材料和较慢释放的疏水材料。 一个支架涂层包括较快释放的PLA-PEO共聚物和较慢释放的PLA-PCL共聚物的共混物。 一种活性剂是紫杉醇。 输送紫杉醇的一种用途是在血管成形术后抑制再狭窄。

    STEERABLE GUIDE WIRE WITH PRESSURE SENSOR AND METHODS OF USE
    7.
    发明申请
    STEERABLE GUIDE WIRE WITH PRESSURE SENSOR AND METHODS OF USE 审中-公开
    带压力传感器的可转向导线和使用方法

    公开(公告)号：US20130237864A1

    公开(公告)日：2013-09-12

    申请号：US13686681

    申请日：2012-11-27

    申请人： Scott T. Mazar ,  Peter T. Keith ,  Jeffrey J. Peters ,  Scott R. Smith

    发明人： Scott T. Mazar ,  Peter T. Keith ,  Jeffrey J. Peters ,  Scott R. Smith

    IPC分类号： A61B5/00 ,  A61B5/021 ,  A61B5/0215

    CPC分类号： A61B5/0215 ,  A61B5/02141 ,  A61B5/026 ,  A61B5/05 ,  A61B5/6851 ,  A61B2562/0247 ,  A61M2025/09083

    摘要： A high performance guide wire with a pressure sensor for measuring blood pressure, may utilize a single electrical lead connected to the guide wire. An integrated circuit, powered by the single electrical connection on the guide wire, may interface with the pressure sensor, and may convert pressure information to an encoded signal. The encoded signal may be detectable in the electrical circuit, and can be used to display a pressure waveform as detected by the pressure sensor. For example, when utilized for percutaneous coronary interventions, such a guide wire can provide high quality blood pressure measurements (e.g., for fractional flow reserve), while also possessing excellent steerability and handling characteristics for navigating tortuous anatomy.

    摘要翻译： 具有用于测量血压的压力传感器的高性能导丝可以利用连接到导丝的单个电引线。 由引导线上的单个电气连接供电的集成电路可以与压力传感器接口，并且可以将压力信息转换为编码信号。 编码的信号在电路中可以是可检测的，并且可以用于显示由压力传感器检测到的压力波形。 例如，当用于经皮冠状动脉介入治疗时，这种导丝可以提供高质量的血压测量（例如，用于分数流量储备），同时对于导航曲折解剖结构也具有优异的可操纵性和操作特性。

    Method for substituting at least one high quality position measurement taken before an interrupting event with a set of upgraded low quality position measurements provided by the same source of measurements after the interrupting event
    9.
    发明授权
    Method for substituting at least one high quality position measurement taken before an interrupting event with a set of upgraded low quality position measurements provided by the same source of measurements after the interrupting event 有权
    在中断事件之前用一组升级的低质量位置测量替代在中断事件之后由同一测量源提供的至少一个高质量位置测量的方法

    公开(公告)号：US07747384B1

    公开(公告)日：2010-06-29

    申请号：US11133798

    申请日：2005-05-17

    申请人： Vivek Bhalchandra Nadkarni ,  Scott R. Smith

    发明人： Vivek Bhalchandra Nadkarni ,  Scott R. Smith

    IPC分类号： G01C21/30

    CPC分类号： G01C21/00 ,  G01S19/41 ,  G01S19/42 ,  G01S19/46 ,  G01S19/49

    摘要： A method for substituting at least one high quality position measurement of an object taken before an interrupting event with a set of upgraded low quality position measurements of the object provided by the same source of measurements after the interrupting event. The method comprises the following steps: (A) obtaining at least one high quality position measurement of the object provided by a source of measurements before the interrupting event; (B) saving at least one high quality position measurement of the object; (C) if at least one position measurement of the object provided by source of measurements after the interrupting event is of substantially high quality, using at least one position measurement of substantially high quality of the object for navigation purposes of the object; and (D) if each position measurement of the object provided by the source of measurements after the interrupting event is of low quality, and if there is not at least one restoration event; then upgrading at least one position measurement of the object by using an upgrade algorithm.

    摘要翻译： 一种用于在中断事件之后用同一测量源提供的对象的一组升级的低质量位置测量来代替在中断事件之前拍摄的对象的至少一个高质量位置测量的方法。 该方法包括以下步骤：（A）在中断事件之前获得由测量源提供的对象的至少一个高质量位置测量; （B）保存对象的至少一个高质量位置测量; （C）如果在中断事件之后由测量源提供的对象的至少一个位置测量具有基本上高的质量，则使用用于对象的导航目的的对象的基本上高质量的至少一个位置测量; 和（D）如果在中断事件之后由测量源提供的对象的每个位置测量质量低，并且如果没有至少一个恢复事件; 然后使用升级算法升级对象的至少一个位置测量。

    Leadless cardiac stimulation systems
    10.
    发明授权
    Leadless cardiac stimulation systems 有权
    无铅心脏刺激系统

    公开(公告)号：US07532933B2

    公开(公告)日：2009-05-12

    申请号：US10971550

    申请日：2004-10-20

    申请人： Roger N. Hastings ,  William J. Drasler ,  Daniel M. Lafontaine ,  Anupama Sadasiva ,  Scott R. Smith

    发明人： Roger N. Hastings ,  William J. Drasler ,  Daniel M. Lafontaine ,  Anupama Sadasiva ,  Scott R. Smith

    IPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/37

    CPC分类号： A61N1/3756 ,  A61N1/0587 ,  A61N1/059 ,  A61N1/08 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37241 ,  A61N1/37288 ,  A61N1/375 ,  A61N1/3787

    摘要： Various configurations of systems that employ leadless electrodes to provide pacing therapy are provided. In one example, a system that provides multiple sites for pacing of myocardium of a heart includes wireless pacing electrodes that are implantable at sites proximate the myocardium using a percutaneous, transluminal, catheter delivery system. Each of the electrodes contains a source of electrical energy for pacing the myocardium and is adapted to receive electromagnetic energy from a source outside the myocardium. The system also includes a source adapted for placement outside the myocardium and that uses locally measured electrocardiograms to synchronize pacing of the heart by sending electromagnetic commands to the electrodes to pace the myocardium surrounding the electrodes. Also disclosed is various configurations of such systems, wireless electrode assemblies, and delivery catheters for delivering and implanting the electrode assemblies.

    摘要翻译： 提供了使用无引线电极来提供起搏治疗的各种构造的系统。 在一个示例中，提供用于心脏心肌的多个部位的系统包括使用经皮，经腔，导管递送系统可植入位于心肌附近的位置的无线起搏电极。 每个电极包含用于起搏心肌的电能源，并且适于从心肌外部的源接收电磁能。 该系统还包括适于放置在心肌外部的源，并且使用局部测量的心电图来通过向电极发送电磁命令来同步心脏的起搏，以对电极周围的心肌进行加速。 还公开了用于递送和植入电极组件的这种系统，无线电极组件和输送导管的各种配置。