利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

433 条记录 (耗时 0.059 秒)

    Endoprosthesis
    3.
    发明申请
    Endoprosthesis 审中-公开
    内假体

    公开(公告)号：US20110160839A1

    公开(公告)日：2011-06-30

    申请号：US12649007

    申请日：2009-12-29

    申请人： Jan Weber ,  Liliana Atanasoska ,  Rajesh Radhakrishnan

    发明人： Jan Weber ,  Liliana Atanasoska ,  Rajesh Radhakrishnan

    IPC分类号： A61F2/82 ,  B05D3/00

    CPC分类号： A61F2/91 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2250/0067

    摘要： An endoprosthesis, e.g., a bioerodable stent, that is treated by plasma immersion ion implantation on the surface and optionally in the bulk. Releasable therapeutic agent, drug, or pharmaceutically active compound may be incorporated into the treated surface of the endoprosthesis to provide desired medical benefits.

    摘要翻译： 内表假体，例如生物可蚀塑的支架，其通过等离子体浸没离子注入在表面上和任选地在本体中进行处理。 可释放的治疗剂，药物或药物活性化合物可以并入内用假体的经处理的表面以提供所需的医疗益处。

    Drug eluting medical devices having porous layers
    4.
    发明授权
    Drug eluting medical devices having porous layers 有权
    具有多孔层的药物洗脱医学装置

    公开(公告)号：US08815273B2

    公开(公告)日：2014-08-26

    申请号：US11881749

    申请日：2007-07-27

    申请人： Liliana Atanasoska ,  Robert W. Warner ,  Michael S. Arney ,  Jan Weber

    发明人： Liliana Atanasoska ,  Robert W. Warner ,  Michael S. Arney ,  Jan Weber

    IPC分类号： A61F13/00 ,  A61F2/06

    CPC分类号： A61L31/16 ,  A61L31/022 ,  A61L31/082 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L2300/608 ,  Y10T428/13 ,  Y10T428/249994

    摘要： In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包括（a）基底和（b）包含设置在基底上的紧密堆积的球形孔的多孔层。 多孔层还可以包含治疗剂。 在另一方面，本发明提供了形成可植入或可插入的医疗装置的方法。 这些方法包括形成前身结构，其包括（i）在其上设置（ii）微球组件的基底。 然后将该微球体组合物用作形成多孔层的模板，随后可以加入治疗剂。

    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION
    9.
    发明申请
    MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION 失效
    用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置

    公开(公告)号：US20090326638A1

    公开(公告)日：2009-12-31

    申请号：US12489948

    申请日：2009-06-23

    申请人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    发明人： Liliana Atanasoska ,  Jan Weber ,  Paul Grosso ,  Robert W. Warner ,  Kasyap V. Seethamraju

    IPC分类号： A61F2/06

    CPC分类号： A61L31/022 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.

    摘要翻译： 根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。 金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。 离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。 根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域， 第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。