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公开(公告)号：US07135556B2
公开(公告)日：2006-11-14
申请号：US10736769
申请日：2003-12-16
IPC分类号： A61K38/47 , C07K16/24 , C07K16/26 , G01N33/58 , G01N33/531
CPC分类号： G01N33/92 , A01K2217/075 , C07K14/705
摘要： We claim an isolated polypeptide having ability of binding with cholesterol. Said polypeptide is useful for investigating regulation of intestinal cholesterol absorption and cholesterol levels. Also, we claim a composition comprising said polypeptide bound to cholesterol or ezetimibe and a fusion protein comprising the polypeptide thereof.
摘要翻译： 我们要求具有与胆固醇结合能力的分离的多肽。 所述多肽可用于调查肠胆固醇吸收和胆固醇水平的调节。 另外，我们要求包含与胆固醇或依泽替米贝结合的所述多肽的组合物和包含其多肽的融合蛋白。
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公开(公告)号：US20120079616A1
公开(公告)日：2012-03-29
申请号：US13271348
申请日：2011-10-12
IPC分类号： A01K67/027 , C12P21/02 , C12N15/63 , C12N5/10 , C12N1/21 , C07K14/47 , C12N15/12 , G01N33/566 , C12Q1/60 , A61K31/397 , G01N33/92 , A61K31/7088 , C12N5/071 , A61P3/00 , C07K16/18
CPC分类号： G01N33/92
摘要： The present invention provides human, rat and mouse NPC1L1 polypeptides and polynucleotides encoding the polypeptides. Also provided are methods for detecting agonists and antagonists of NPC1L1. Inhibitors of NPC1L1 can be used for inhibiting intestinal cholesterol absorption in a subject.
摘要翻译： 本发明提供人，大鼠和小鼠NPC1L1多肽和编码多肽的多核苷酸。 还提供了用于检测NPC1L1的激动剂和拮抗剂的方法。 NPC1L1的抑制剂可用于抑制受试者肠内胆固醇的吸收。
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公开(公告)号：US06933107B2
公开(公告)日：2005-08-23
申请号：US10438637
申请日：2003-05-15
申请人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
发明人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
CPC分类号： G01N33/502 , A61K31/397 , C12Q1/60 , G01N33/5008 , G01N33/5044 , G01N33/92 , G01N2333/4704
摘要： The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.
摘要翻译： 提出了作为胆固醇吸收抑制剂的氮杂环丁酮化合物的使用，用于发现和表征参与生物系统中胆固醇和/或胆固醇酯的运输或吸收的蛋白质。 这些化合物可用作竞争性结合测定的工具，以发现和表征可用作胆固醇吸收抑制剂的其他化学试剂。 本发明的新化合物也是胆固醇吸收的高效抑制剂。
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公开(公告)号：US07723020B2
公开(公告)日：2010-05-25
申请号：US11586303
申请日：2006-10-25
申请人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
发明人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
IPC分类号： C12Q1/00 , G01N33/53 , G01N33/567 , A01N43/04 , A61K31/397
CPC分类号： G01N33/502 , A61K31/397 , C12Q1/60 , G01N33/5008 , G01N33/5044 , G01N33/92 , G01N2333/4704
摘要： The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.
摘要翻译： 提出了作为胆固醇吸收抑制剂的氮杂环丁酮化合物的使用，用于发现和表征参与生物系统中胆固醇和/或胆固醇酯的运输或吸收的蛋白质。 这些化合物可用作竞争性结合测定的工具，以发现和表征可用作胆固醇吸收抑制剂的其他化学试剂。 本发明的新化合物也是胆固醇吸收的高效抑制剂。
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公开(公告)号：US07144696B2
公开(公告)日：2006-12-05
申请号：US11123615
申请日：2005-05-06
申请人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
发明人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
CPC分类号： G01N33/502 , A61K31/397 , C12Q1/60 , G01N33/5008 , G01N33/5044 , G01N33/92 , G01N2333/4704
摘要： The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.
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公开(公告)号：US06632933B2
公开(公告)日：2003-10-14
申请号：US09918397
申请日：2001-07-30
申请人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
发明人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
IPC分类号： C07H1526
CPC分类号： G01N33/502 , A61K31/397 , C12Q1/60 , G01N33/5008 , G01N33/5044 , G01N33/92 , G01N2333/4704
摘要： The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.
摘要翻译： 提出了作为胆固醇吸收抑制剂的氮杂环丁酮化合物的使用，用于发现和表征参与生物系统中胆固醇和/或胆固醇酯的运输或吸收的蛋白质。 这些化合物可用作竞争性结合测定的工具，以发现和表征可用作胆固醇吸收抑制剂的其他化学试剂。 本发明的新化合物也是胆固醇吸收的高效抑制剂
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公开(公告)号：US06593078B1
公开(公告)日：2003-07-15
申请号：US09547509
申请日：2000-04-12
申请人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
发明人： Scott W. Altmann , Duane A. Burnett , Harry R. Davis, Jr. , Michael P. Graziano , Maureen Laverty , Xiaorui Yao
IPC分类号： C12Q100
CPC分类号： G01N33/502 , A61K31/397 , C12Q1/60 , G01N33/5008 , G01N33/5044 , G01N33/92 , G01N2333/4704
摘要： The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.
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公开(公告)号：US08257921B1
公开(公告)日：2012-09-04
申请号：US12644674
申请日：2009-12-22
申请人： Xiaorui Yao , Scott W. Altmann , Liji Zhu
发明人： Xiaorui Yao , Scott W. Altmann , Liji Zhu
IPC分类号： C12Q1/68
CPC分类号： G01N33/5023 , C12Q1/6883 , C12Q2600/136 , G01N2333/775
摘要： The present invention provides, in part, methods for identifying inhibitors of NRIP1 and methods of using such inhibitors. Methods of treating NRIP1-mediated disorders using NRIP1 inhibitor are also provided.
摘要翻译： 本发明部分地提供了鉴定NRIP1抑制剂的方法和使用这种抑制剂的方法。 还提供了使用NRIP1抑制剂治疗NRIP1介导的病症的方法。
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公开(公告)号：US20090098128A1
公开(公告)日：2009-04-16
申请号：US11710295
申请日：2007-02-22
申请人： Scott W. Altmann , Xiaorui Yao , Kim Ann O'Neill , Brian E. Hawes
发明人： Scott W. Altmann , Xiaorui Yao , Kim Ann O'Neill , Brian E. Hawes
IPC分类号： A61K39/395 , C07K14/00 , C12N9/12 , C12N15/11 , A01K67/027 , G01N33/566 , C12Q1/60 , G01N33/53 , C12P21/04 , C12N15/00 , C12N5/06 , C07K16/18
CPC分类号： C07K14/705 , G01N33/92 , G01N2500/00
摘要： The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
摘要翻译： 本发明部分提供来自各种物种的NPC1L1。 还阐述了使用本文所述的NPC1L1多肽和多核苷酸的方法，例如在筛选测定中。
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公开(公告)号：US20140243233A1
公开(公告)日：2014-08-28
申请号：US14236501
申请日：2012-08-02
申请人： Scott W. Altmann
发明人： Scott W. Altmann
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N33/487 , G01N33/6842 , G01N2333/775 , G01N2800/044 , G01N2800/50 , G01N2800/52
摘要： This invention provides a capture/detection antibody-based method for measuring the amount of a high density lipoprotein (HDL) subpopulation present in a sample, wherein each particle of the HDL subpopulation being measured is characterized by the presence of a plurality of defined protein epitopes. This invention also provides related analytical and diagnostic methods, as well as kits for performing same.
摘要翻译： 本发明提供了用于测量样品中存在的高密度脂蛋白（HDL）亚群的量的基于捕获/检测抗体的方法，其中所测量的HDL亚群的每个颗粒的特征在于存在多个限定的蛋白质表位 。 本发明还提供相关的分析和诊断方法，以及用于执行相同的试剂盒。
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